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  2. THOC1 - THO complex subunit 1 Gene

THOC1 - THO complex subunit 1 Gene

中文名称:THO 复合亚基 1

种属: Homo sapiens

同用名: P84; HPR1; P84N5

基因 ID: 9984 | 基因类型: protein coding

关于 THOC1

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:214,520-268,047 (from NCBI)

This gene has 19 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in testis (RPKM 6.7), bone marrow (RPKM 6.1) and 25 other tissues.

功能概要

HPR1 是 TREX (转录/导出) 复合体的一部分,其中包括 TEX1 (MIM 606929) 、THO2 (MIM 300395) 、ALY (MIM 604171) 和 UAP56 (MIM 142560) 。[OMIM 提供,2010 年 11 月]

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]

THOC1 基因产物(1)

mRNA Protein Name
NM_005131.3 NP_005122.2 THO complex subunit 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15870275 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA export from nucleus IMP
IMP: 通过突变表型推断
22144908 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of THO complex IDA
IDA: 通过直接分析推断
15998806 GOA
part of THO complex part of transcription export complex IDA
IDA: 通过直接分析推断
15998806 GOA
colocalizes with chromosome, telomeric region IDA
IDA: 通过直接分析推断
24270157 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15358532 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15358532 GOA
part of transcription export complex IDA
IDA: 通过直接分析推断
15833825 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

THOC1 蛋白结构

efThoc1

efThoc1: THO complex subunit 1 transcription elongation factor (71 - 552)

Death

Death: Death domain (573 - 651)

  • 0
  • 200
  • 400
  • 600
  • 657 a.a.
蛋白主名 其他名称

THO complex subunit 1

THO complex 1

THOC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra THOC1 Q96FV9 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra THOC1 Q96FV9 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra THOC1 Q96FV9 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra THOC1 Q96FV9 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra THOC1 Q96FV9 AKAP9 Homo sapiens Q6PJH3
Y2H Array
32296183
Intra THOC1 Q96FV9 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra THOC1 Q96FV9 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra THOC1 Q96FV9 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra THOC1 Q96FV9 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra THOC1 Q96FV9 THOC5 Homo sapiens Q13769
Anti Bait CoIP
23299939
Intra THOC1 Q96FV9 THOC5 Homo sapiens Q13769
Anti Tag CoIP
26496610
Intra THOC1 Q96FV9 THOC5 Homo sapiens Q13769
Y2H
22365833
Intra THOC1 Q96FV9 THOC5 Homo sapiens Q13769
Anti Tag CoIP
28514442
Intra THOC1 Q96FV9 THOC5 Homo sapiens Q13769
Anti Tag CoIP
33961781
Intra THOC1 Q96FV9 THOC5 Homo sapiens Q13769
IF
19165146
Intra THOC1 Q96FV9 THOC5 Homo sapiens Q13769
Anti Bait CoIP
19165146
Intra THOC1 Q96FV9 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra THOC1 Q96FV9 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra THOC1 Q96FV9 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra THOC1 Q96FV9 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra THOC1 Q96FV9 PPP1R12C Homo sapiens Q9BZL4
Y2H Array
32296183
Intra THOC1 Q96FV9 PPP1R12C Homo sapiens Q9BZL4
Y2H Prey Pooling
32296183
Intra THOC1 Q96FV9 PPP1R12C Homo sapiens Q9BZL4
Validated Y2H
32296183
Intra THOC1 Q96FV9 MOAP1 Homo sapiens Q96BY2
Y2H Array
25416956
Intra THOC1 Q96FV9 MOAP1 Homo sapiens Q96BY2
Validated Y2H
25416956
Intra THOC1 Q96FV9 MOAP1 Homo sapiens Q96BY2
Y2H Array
31515488
Intra THOC1 Q96FV9 MOAP1 Homo sapiens Q96BY2
Y2H Prey Pooling
25416956
Intra THOC1 Q96FV9 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Intra THOC1 Q96FV9 TADA2A Homo sapiens O75478
Y2H Prey Pooling
32296183
Intra THOC1 Q96FV9 TADA2A Homo sapiens O75478
Y2H Array
32296183
Intra THOC1 Q96FV9 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra THOC1 Q96FV9 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra THOC1 Q96FV9 MAGEB4 Homo sapiens O15481
Y2H Array
32296183
Intra THOC1 Q96FV9 MAGEB4 Homo sapiens O15481
Y2H Prey Pooling
32296183
Intra THOC1 Q96FV9 RABGEF1 Homo sapiens Q9UJ41
Y2H Prey Pooling
25416956
Intra THOC1 Q96FV9 EXOC5 Homo sapiens O00471
Y2H Prey Pooling
32296183
Intra THOC1 Q96FV9 EXOC5 Homo sapiens O00471
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta THOC1 VGNC VGNC:79175
Canis familiaris THOC1 VGNC VGNC:47348
Bos taurus THOC1 VGNC VGNC:35840
Mus musculus THOC1 MGD MGI:1919668
Felis catus THOC1 VGNC VGNC:66166
Rattus norvegicus THOC1 RGD RGD:1308657