TADA2A - transcriptional adaptor 2A Gene

中文名称：转录衔接子 2A

种属: Homo sapiens

同用名: ADA2; ADA2A; KL04P; hADA2; TADA2L

关于 TADA2A

功能概要

许多 DNA 结合转录激活蛋白通过与结合在基础启动子上的一般转录机制在功能上相互作用来提高 RNA 聚合酶 II 介导的基因转录的起始率。这种激活通常需要衔接蛋白，可能使核小体乙酰化和不稳定，从而减轻启动子处的染色质限制。由该基因编码的蛋白质是一种转录激活适配器，已被发现是 PCAF 组蛋白乙酰化酶复合物的一部分。已经描述了几种编码该基因不同亚型的可变剪接转录物变体，但尚未确定其中一些变体的全长性质。[RefSeq 提供，2009 年 10 月]

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]