TADA3 - transcriptional adaptor 3 Gene

中文名称：转录接头 3

种属: Homo sapiens

同用名: ADA3; NGG1; hADA3; STAF54; TADA3L

关于 TADA3

功能概要

DNA 结合转录激活蛋白通过与结合到基础启动子和接头蛋白的转录机制相互作用来提高转录速率，可能是通过核小体的乙酰化和去稳定化。由该基因编码的蛋白质是一种转录激活因子衔接子，是组蛋白乙酰转移酶 (HAT) 共激活因子复合物的一个组成部分，后者在染色质调节和细胞周期进程中起着至关重要的作用。与复合物的其他成分一起，这种蛋白质将与特定启动子结合的转录激活因子、组蛋白乙酰化和转录机制联系起来。该蛋白还参与 p53 肿瘤抑制蛋白的稳定和激活，该蛋白在细胞对 DNA 损伤的反应中发挥作用。交替剪接导致该基因的多个转录变体。[RefSeq 提供，2013 年 5 月]

DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]