2. Gene
  3. USP5 - ubiquitin specific peptidase 5 Gene

USP5 - ubiquitin specific peptidase 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素特异性肽酶 5

种属: Homo sapiens

同用名: ISOT

基因 ID: 8078 | 基因类型: protein coding

关于 USP5

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,852,150-6,866,632 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 36.2), brain (RPKM 33.4) and 25 other tissues.

功能概要

泛素 (见 MIM 191339) 依赖性蛋白水解是一种复杂的蛋白质代谢途径，涉及多种细胞功能，如维持染色质结构、受体功能和异常蛋白质的降解。该过程的后期步骤涉及将降解蛋白质上的多聚泛素链分解为泛素单体。 USP5 通过连续的 exo 机制分解支链多聚泛素链，从链的近端开始 (Wilkinson 等人，1995 [PubMed 7578059]) 。[OMIM 提供，2010 年 3 月]

Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]

USP5 基因产物(6)

mRNA Protein Name
NM_001098536.2 NP_001092006.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 1
NM_001382588.1 NP_001369517.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 3
NM_001382589.1 NP_001369518.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 4
NM_001382590.1 NP_001369519.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 5
NM_001382591.1 NP_001369520.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 6
NM_003481.3 NP_003472.2 ubiquitin carboxyl-terminal hydrolase 5 isoform 2

USP5 蛋白结构

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (199 - 271)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (325 - 853)

UBA

UBA: UBA/TS-N domain (656 - 691)

UBA

UBA: UBA/TS-N domain (725 - 759)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 858 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 5

deubiquitinating enzyme 5

重组 USP5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74479 USP5 Protein, Human (sf9, His) P45974-2 (M1-S835) ≥95%

关联疾病

疾病名称 别名
Non-Syndromic X-Linked Intellectual Disability 99

Mrx99

X-Linked Mental Retardation 99
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13814 PR-619 99.38% 否
HY-13264 Degrasyn 99.70% 否
HY-139979 USP5-IN-1 Inhibitor 99.80% 否
HY-111408 EOAI3402143 Inhibitor 98.95% 否
HY-122243 IU1-47 Inhibitor 99.68% 否
HY-103435 Vialinin A Inhibitor 99.89% 否
HY-134817 USP7-IN-8 Inhibitor 99.04% 否
HY-RS15561 USP5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta USP5 VGNC VGNC:78747
Canis familiaris USP5 VGNC VGNC:48201
Felis catus USP5 VGNC VGNC:66893
Mus musculus USP5 MGD MGI:1347343
Bos taurus USP5 VGNC VGNC:36735
Rattus norvegicus USP5 RGD RGD:1308438
Others USP5 NCBI
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