USP5 - ubiquitin specific peptidase 5 Gene

中文名称：泛素特异性肽酶 5

种属: Homo sapiens

同用名: ISOT

关于 USP5

功能概要

泛素 (见 MIM 191339) 依赖性蛋白水解是一种复杂的蛋白质代谢途径，涉及多种细胞功能，如维持染色质结构、受体功能和异常蛋白质的降解。该过程的后期步骤涉及将降解蛋白质上的多聚泛素链分解为泛素单体。 USP5 通过连续的 exo 机制分解支链多聚泛素链，从链的近端开始 (Wilkinson 等人，1995 [PubMed 7578059]) 。[OMIM 提供，2010 年 3 月]

Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]