DAZAP2 - DAZ associated protein 2 Gene

中文名称：DAZ 相关蛋白 2

种属: Homo sapiens

同用名: PRTB

关于 DAZAP2

功能概要

该基因编码一种富含脯氨酸的蛋白质，该蛋白质通过类 DAZ 重复序列与无精症缺失基因 (DAZ) 和类无精症缺失基因相互作用。这种蛋白质还与转化生长因子-β 信号分子 SARA (受体激活的 Smad 锚) 、真核起始因子 4G 和调节其在含有核斑点的剪接因子中的稳定性的 E3 泛素酶相互作用。编码的蛋白质可能在各种生物和病理过程中发挥作用，包括精子发生、细胞信号和转录调节、翻译停滞期间应激颗粒的形成、RNA 剪接和多发性骨髓瘤的发病机制。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 10 月]

This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]