1. Gene
  2. ISX - intestine specific homeobox Gene

ISX - intestine specific homeobox Gene

中文名称:肠特异性同源盒

种属: Homo sapiens

同用名: Pix-1; RAXLX

基因 ID: 91464 | 基因类型: protein coding

关于 ISX

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:35,066,158-35,087,387 (from NCBI)

This gene has 2 transcripts (splice variants), 106 orthologues, 50 paralogues and is associated with 51 phenotypes. Biased expression in duodenum (RPKM 20.1), colon (RPKM 15.2) and 1 other tissue.

功能概要

同源框基因编码 DNA 结合蛋白,其中许多被认为与早期胚胎发育有关。同源框基因编码 60 至 63 个氨基酸的 DNA 结合域,称为同源域。该基因是 RAXLX 同源框基因家族的成员。[RefSeq 提供,2008 年 7 月]

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 Amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008]

ISX 基因产物(1)

mRNA Protein Name
NM_001303508.2 NP_001290437.1 intestine-specific homeobox
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ISX 蛋白结构

Homeobox

Homeobox: Homeobox domain (83 - 139)

  • 0
  • 100
  • 200
  • 245 a.a.
蛋白主名 其他名称

intestine-specific homeobox

RAX-like homeobox

ISX 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ISX Q2M1V0 POU6F2 Homo sapiens P78424 32296183
种属内
ISX Q2M1V0 POU6F2 Homo sapiens P78424 32296183
种属内
ISX Q2M1V0 GSC2 Homo sapiens O15499 32296183
种属内
ISX Q2M1V0 GSC2 Homo sapiens O15499 32296183
种属内
ISX Q2M1V0 UBAP2 Homo sapiens Q5T6F2 32296183
种属内
ISX Q2M1V0 UBAP2 Homo sapiens Q5T6F2 32296183
种属内
ISX Q2M1V0 UBAP2 Homo sapiens Q5T6F2 32296183
种属内
ISX Q2M1V0 ROR2 Homo sapiens Q01974 32296183
种属内
ISX Q2M1V0 ROR2 Homo sapiens Q01974 32296183
种属内
ISX Q2M1V0 DAZAP2 Homo sapiens Q15038 32296183
种属内
ISX Q2M1V0 DAZAP2 Homo sapiens Q15038 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypervitaminosis A

Hypervitaminosis A, Susceptibility To

Hyperalimentation Of Vitamin A

Macular Degeneration, Age-Related, 10

ARMD10

Age Related Macular Degeneration 10

Macular Degeneration, Age-Related, Type 10

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ISX VGNC VGNC:42115
Mus musculus ISX MGD MGI:1918847
Macaca mulatta ISX VGNC VGNC:107796
Bos taurus ISX VGNC VGNC:30305
Felis catus ISX VGNC VGNC:62981
Rattus norvegicus ISX RGD RGD:1592776