UBC - ubiquitin C Gene

中文名称：泛素 C

种属: Homo sapiens

同用名: HMG20

基因 ID: 7316 | 基因类型: protein coding

关于 UBC

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:124,911,646-124,914,650 (from NCBI)

This gene has 13 transcripts (splice variants), 60 orthologues and 10 paralogues. Ubiquitous expression in bone marrow (RPKM 1559.8), gall bladder (RPKM 1270.7) and 25 other tissues.

功能概要

该基因代表泛素基因，泛素 C。编码的蛋白质是多聚泛素前体。泛素单体或聚合物的结合可在细胞内产生各种效应，具体取决于泛素结合的残基。泛素化与蛋白质降解、DNA 修复、细胞周期调节、激酶修饰、胞吞作用和其他细胞信号通路的调节有关。[RefSeq 提供，2010 年 8 月]

This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or Polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of Other cell signaling pathways. [provided by RefSeq, Aug 2010]

UBC 基因产物(1)

mRNA	Protein	Name
NM_021009.7	NP_066289.3	polyubiquitin-C

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	8702753	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBC 蛋白结构

ubiquitin

0
200
400
600
685 a.a.

蛋白主名

其他名称

polyubiquitin-C

UBC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UBC	P0CG48	BUB1B	Homo sapiens	O60566	Anti Tag CoIP	19407811
种属内	UBC	P0CG48	MALT1	Homo sapiens	Q9UDY8	Anti Tag CoIP	17948050
种属内	UBC	P0CG48	UBE2G2	Homo sapiens	P60604	Validated Y2H	32296183
种属内	UBC	P0CG48	UBE2G2	Homo sapiens	P60604	Y2H Array	32296183
种属内	UBC	P0CG48	UBE2G2	Homo sapiens	P60604	Y2H Prey Pooling	32296183
种属内	UBC	P0CG48	UBE3A	Homo sapiens	Q05086-3	Y2H Array	32296183
种属内	UBC	P0CG48	UBE3A	Homo sapiens	Q05086-3	Y2H Prey Pooling	32296183
种属内	UBC	P0CG48	UBE3A	Homo sapiens	Q05086-3	Validated Y2H	32296183
种属内	UBC	P0CG48	FAM168A	Homo sapiens	Q92567-2	Validated Y2H	32296183
种属内	UBC	P0CG48	MTURN	Homo sapiens	Q8N3F0	Validated Y2H	32296183
种属内	UBC	P0CG48	EPN2	Homo sapiens	O95208-2	Y2H Array	32296183
种属内	UBC	P0CG48	EPN2	Homo sapiens	O95208-2	Y2H Prey Pooling	32296183
种属内	UBC	P0CG48	LCK	Homo sapiens	P06239	NMR	18539162
种属内	UBC	P0CG48	PRKCA	Homo sapiens	P17252	Anti Tag CoIP	18566587
种属间	UBC	P0CG48	RAD23	Saccharomyces cerevisiae	P32628	Pull Down	20059542
种属内	UBC	P0CG48	ABCG2	Homo sapiens	Q9UNQ0	Anti Bait CoIP	19909340
种属内	UBC	P0CG48	NPLOC4	Homo sapiens	Q8TAT6	Anti Tag CoIP	35271311
种属内	UBC	P0CG48	NPLOC4	Homo sapiens	Q8TAT6	ITC	17070805
种属内	UBC	P0CG48	BMI1	Homo sapiens	P35226	Pull Down	20601937
种属内	UBC	P0CG48	YOD1	Homo sapiens	Q5VVQ6	Validated Y2H	32296183
种属间	UBC	P0CG48	P0C6X7-PRO_0000037311	Human SARS coronavirus	P0C6X7-PRO_0000037311	Cleavage	32726803
种属间	UBC	P0CG48	P0C6X7-PRO_0000037311	Human SARS coronavirus	P0C6X7-PRO_0000037311	Probe Interaction	32726803
种属间	UBC	P0CG48	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Probe Interaction	32726803
种属间	UBC	P0CG48	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Cleavage	32726803
种属内	UBC	P0CG48	DESI1	Homo sapiens	Q6ICB0	Validated Y2H	32296183
种属内	UBC	P0CG48	POLH	Homo sapiens	Q9Y253	Y2H	16763556
种属内	UBC	P0CG48	POLH	Homo sapiens	Q9Y253	Pull Down	16763556
种属内	UBC	P0CG48	CDIP1	Homo sapiens	Q9H305	Validated Y2H	32296183
种属内	UBC	P0CG48	SENP3	Homo sapiens	Q9H4L4	Pull Down	19680224
种属内	UBC	P0CG48	SQSTM1	Homo sapiens	Q13501	Pull Down	12857745
种属内	UBC	P0CG48	SQSTM1	Homo sapiens	Q13501	Pull Down	8702753
种属内	UBC	P0CG48	SQSTM1	Homo sapiens	Q13501	Pull Down	19427866
种属内	UBC	P0CG48	NFKBIA	Homo sapiens	P25963	Anti Bait CoIP	17318178
种属内	UBC	P0CG48	NFKBIA	Homo sapiens	P25963	Anti Tag CoIP	17318178
种属内	UBC	P0CG48	NFKBIA	Homo sapiens	P25963	Pull Down	18539148
种属内	UBC	P0CG48	ASAP2	Homo sapiens	O43150	Pull Down	17255943
种属内	UBC	P0CG48	SH3KBP1	Homo sapiens	Q96B97	NMR	19111555
种属内	UBC	P0CG48	SH3KBP1	Homo sapiens	Q96B97	NMR	18680311
种属内	UBC	P0CG48	ASAP1	Homo sapiens	Q9ULH1	Pull Down	17255943
种属内	UBC	P0CG48	ASAP1	Homo sapiens	Q9ULH1	Anti Tag CoIP	17255943
种属内	UBC	P0CG48	PARP1	Homo sapiens	P09874	Anti Bait CoIP	19779455
种属内	UBC	P0CG48	PARP1	Homo sapiens	P09874	Pull Down	19779455
种属内	UBC	P0CG48	MAP3K7	Homo sapiens	O43318	Anti Tag CoIP	19820695
种属内	UBC	P0CG48	MAP3K7	Homo sapiens	O43318	Pull Down	16845370
种属内	UBC	P0CG48	MAP3K7	Homo sapiens	O43318	Anti Bait CoIP	19820695
种属内	UBC	P0CG48	TRAF6	Homo sapiens	Q9Y4K3	Anti Bait CoIP	17703191
种属内	UBC	P0CG48	PSMD4	Homo sapiens	P55036	Pull Down	20059542
种属内	UBC	P0CG48	PSMD4	Homo sapiens	P55036	Pull Down	9488668
种属内	UBC	P0CG48	PSMD4	Homo sapiens	P55036	Far-WB	8570649
种属内	UBC	P0CG48	PSMD4	Homo sapiens	P55036	SPR	19798103
种属内	UBC	P0CG48	PSMD4	Homo sapiens	P55036	Pull Down	19796170
种属内	UBC	P0CG48	TP53	Homo sapiens	P04637	Anti Tag CoIP	17170702
种属内	UBC	P0CG48	TP53	Homo sapiens	P04637	Anti Tag CoIP	17159902
种属内	UBC	P0CG48	TP53	Homo sapiens	P04637	Pull Down	18566590
种属内	UBC	P0CG48	TP53	Homo sapiens	P04637	Anti Bait CoIP	18309296
种属内	UBC	P0CG48	TP53	Homo sapiens	P04637	Pull Down	17139261
种属内	UBC	P0CG48	TP53	Homo sapiens	P04637	Anti Tag CoIP	17568776
种属内	UBC	P0CG48	TP53	Homo sapiens	P04637	Pull Down	18388957
种属内	UBC	P0CG48	TP53	Homo sapiens	P04637	Pull Down	19619542
种属内	UBC	P0CG48	TP53	Homo sapiens	P04637	Anti Bait CoIP	18566590
种属内	UBC	P0CG48	TP53	Homo sapiens	P04637	Anti Bait CoIP	17268548
种属内	UBC	P0CG48	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
种属内	UBC	P0CG48	ELAVL1	Homo sapiens	Q15717	Anti Tag CoIP	19322201
种属内	UBC	P0CG48	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	18566590
种属内	UBC	P0CG48	MDM2	Homo sapiens	Q00987	Pull Down	19166840
种属内	UBC	P0CG48	MDM2	Homo sapiens	Q00987	Pull Down	18566590
种属内	UBC	P0CG48	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	19098711
种属内	UBC	P0CG48	GRK2	Homo sapiens	P25098	Anti Bait CoIP	17006543
种属内	UBC	P0CG48	NFATC4	Homo sapiens	Q14934	Anti Bait CoIP	19026640
种属内	UBC	P0CG48	NFATC4	Homo sapiens	Q14934	Anti Tag CoIP	19026640
种属内	UBC	P0CG48	RDH12	Homo sapiens	Q96NR8	Anti Tag CoIP	20006610
种属内	UBC	P0CG48	MYC	Homo sapiens	P01106	Anti Tag CoIP	19131971
种属内	UBC	P0CG48	MAP3K4	Homo sapiens	Q9Y6R4	Anti Tag CoIP	16256071
种属内	UBC	P0CG48	MAP3K4	Homo sapiens	Q9Y6R4	Anti Bait CoIP	16256071
种属内	UBC	P0CG48	HTT	Homo sapiens	P42858	Y2H Array	32814053
种属内	UBC	P0CG48	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	UBC	P0CG48	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	UBC	P0CG48	XIAP	Homo sapiens	P98170	Pull Down	17318174
种属内	UBC	P0CG48	XIAP	Homo sapiens	P98170	Anti Bait CoIP	17318174
种属内	UBC	P0CG48	XIAP	Homo sapiens	P98170	Anti Tag CoIP	17318174
种属内	UBC	P0CG48	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	32296183
种属内	UBC	P0CG48	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
种属内	UBC	P0CG48	TAX1BP1	Homo sapiens	Q86VP1	Pull Down	18239685
种属内	UBC	P0CG48	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
种属内	UBC	P0CG48	BCL2L12	Homo sapiens	Q9HB09-1	Anti Tag CoIP	19376117
种属内	UBC	P0CG48	BCL2L12	Homo sapiens	Q9HB09-1	Pull Down	19376117
种属内	UBC	P0CG48	NCK2	Homo sapiens	O43639	NMR	18539162
种属内	UBC	P0CG48	DENR	Homo sapiens	O43583	Anti Tag CoIP	16936636
种属内	UBC	P0CG48	DENR	Homo sapiens	O43583	Anti Tag CoIP	16874301
种属内	UBC	P0CG48	DENR	Homo sapiens	O43583	Anti Bait CoIP	16936636
种属内	UBC	P0CG48	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
种属内	UBC	P0CG48	DAZAP2	Homo sapiens	Q15038	Validated Y2H	32296183
种属内	UBC	P0CG48	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
种属内	UBC	P0CG48	CSF3R	Homo sapiens	Q99062	Anti Tag CoIP	17363902
种属内	UBC	P0CG48	CSF3R	Homo sapiens	Q99062	Pull Down	17363902
种属内	UBC	P0CG48	RELA	Homo sapiens	Q04206	Pull Down	17183367
种属内	UBC	P0CG48	RELA	Homo sapiens	Q04206	Anti Bait CoIP	17183367
种属内	UBC	P0CG48	RELA	Homo sapiens	Q04206	Anti Bait CoIP	19322197
种属内	UBC	P0CG48	RELA	Homo sapiens	Q04206	Pull Down	19322197
种属内	UBC	P0CG48	POLI	Homo sapiens	Q9UNA4	Y2H	16763556
种属内	UBC	P0CG48	NBR1	Homo sapiens	Q14596	Pull Down	24879152
种属内	UBC	P0CG48	NBR1	Homo sapiens	Q14596	Pull Down	19427866
种属内	UBC	P0CG48	NBR1	Homo sapiens	Q14596	IF	19427866
种属内	UBC	P0CG48	UBAC1	Homo sapiens	Q9BSL1	Validated Y2H	32296183
种属内	UBC	P0CG48	RYBP	Homo sapiens	Q8N488	ITC	17070805
种属内	UBC	P0CG48	STAM	Homo sapiens	Q92783	NMR	12750381
种属内	UBC	P0CG48	STAM	Homo sapiens	Q92783	SPR	12750381
种属内	UBC	P0CG48	STAM	Homo sapiens	Q92783	NMR	19111546
种属内	UBC	P0CG48	PLSCR4	Homo sapiens	Q9NRQ2	Validated Y2H	32296183
种属内	UBC	P0CG48	DAXX	Homo sapiens	Q9UER7	Y2H Pooling	20936779
种属内	UBC	P0CG48	SNX9	Homo sapiens	Q9Y5X1	Anti Tag CoIP	20491914
种属内	UBC	P0CG48	ZFAND5	Homo sapiens	O76080	Anti Tag CoIP	16424905
种属内	UBC	P0CG48	ATXN3	Homo sapiens	P54252-1	Anti Tag CoIP	19153604
种属内	UBC	P0CG48	ATXN3	Homo sapiens	P54252-1	Anti Bait CoIP	19153604
种属内	UBC	P0CG48	ATXN3	Homo sapiens	P54252-1	Pull Down	14559776
种属内	UBC	P0CG48	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
种属内	UBC	P0CG48	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
种属内	UBC	P0CG48	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
种属内	UBC	P0CG48	ADRM1	Homo sapiens	Q16186	Pull Down	20059542
种属内	UBC	P0CG48	RAD23B	Homo sapiens	P54727	Pull Down	20059542
种属内	UBC	P0CG48	RAD23B	Homo sapiens	P54727	Validated Y2H	32296183
种属间	UBC	P0CG48	Ikbkg	Mus musculus	O88522	Pull Down	19763089
种属间	UBC	P0CG48	rev	Human immunodeficiency virus	P04325	Pull Down	17067581
种属间	UBC	P0CG48	Rbck1	Rattus norvegicus	Q62921	Anti Tag CoIP	19796170
种属间	UBC	P0CG48	Rbck1	Rattus norvegicus	Q62921	Pull Down	19796170

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Phlyctenulosis

Phlyctenular Keratoconjunctivitis

Strumous Ophthalmia

Middle East Respiratory Syndrome

Mers	Mers - [Middle East Respiratory Syndrome]

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Paget'S Disease Of Bone

Osteitis Deformans	Paget Disease Of Bone
Osseous Paget'S Disease	Paget Disease Of Bone, Familial
Bone Paget Disease	Familial Paget'S Disease Of Bone
Paget'S Bone Disease	Familial Paget Disease Of Bone
Paget Disease, Bone	Pdb
Pagets Bone Disease

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Myoclonic Epilepsy Of Lafora

Lafora Disease	Epilepsy, Progressive Myoclonic 2b
EPM2	Melf
Epilepsy, Progressive Myoclonic 2a	Epm2a
Lafora'S Disease	Lafora Body Disease
Lbd	Epilepsy, Progressive Myoclonic, 2a
Lafora Progressive Myoclonic Epilepsy	Epilepsy Progressive Myoclonic 2
Lafora Body Disorder	Pme Type 2
Progressive Myoclonic Epilepsy Type 2	Progressive Myoclonus Epilepsy Type 2
Epilepsy, Progressive Myoclonic 2	Epm2b
Ld	Progressive Myoclonic Epilepsy 2
Progressive Myoclonic Epilepsy 2a	Progressive Myoclonic Epilepsy 2b
Progressive Myoclonic Epilepsy Lafora Type	Epilepsy, Myoclonic, Of Lafora

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-120934	C25-140	Inhibitor	99.86%	否
HY-13811	NSC697923		99.93%	否
HY-115453	UBCS039	Activator	99.06%	否
HY-124602	DI-591	Inhibitor	99.42%	否
HY-126075A	WS-383	Inhibitor	99.88%	否
HY-145169	AZ194	Inhibitor	99.83%	否
HY-161470	WS-384		/	否
HY-W264347	DCN1-UBC12-IN-4	Inhibitor	≥95.0%	否
HY-126075	WS-383 free base	Inhibitor	/	否
HY-125660	Leucettamol A	Inhibitor	/	否
HY-131667	Hdm2 E3 ligase inhibitor 1		/	否
HY-142691	DCN1-UBC12-IN-1	Inhibitor	/	否
HY-142692	DCN1-UBC12-IN-3	Inhibitor	/	否
HY-142694	DCN1-UBC12-IN-2	Inhibitor	/	否
HY-157728	ML307	Inhibitor	/	否
HY-RS15334	UBC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-111505A	NAcM-OPT hydrochloride	Inducer	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	UBC	MGD	MGI:98889
Rattus norvegicus	UBC	RGD	RGD:621244
Bos taurus	UBC	VGNC	VGNC:107263
Others	UBC	NCBI

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