2. Gene
  3. UBC - ubiquitin C Gene

UBC - ubiquitin C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素 C

种属: Homo sapiens

同用名: HMG20

基因 ID: 7316 | 基因类型: protein coding

关于 UBC

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:124,911,646-124,914,650 (from NCBI)

This gene has 13 transcripts (splice variants), 60 orthologues and 10 paralogues. Ubiquitous expression in bone marrow (RPKM 1559.8), gall bladder (RPKM 1270.7) and 25 other tissues.

功能概要

该基因代表泛素基因，泛素 C。编码的蛋白质是多聚泛素前体。泛素单体或聚合物的结合可在细胞内产生各种效应，具体取决于泛素结合的残基。泛素化与蛋白质降解、DNA 修复、细胞周期调节、激酶修饰、胞吞作用和其他细胞信号通路的调节有关。[RefSeq 提供，2010 年 8 月]

This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or Polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]

UBC 基因产物(1)

mRNA Protein Name
NM_021009.7 NP_066289.3 polyubiquitin-C
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
8702753 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBC 蛋白结构

ubiquitin

ubiquitin: Ubiquitin family (6 - 74)

ubiquitin

ubiquitin: Ubiquitin family (82 - 150)

ubiquitin

ubiquitin: Ubiquitin family (158 - 226)

ubiquitin

ubiquitin: Ubiquitin family (234 - 302)

ubiquitin

ubiquitin: Ubiquitin family (310 - 378)

ubiquitin

ubiquitin: Ubiquitin family (386 - 454)

ubiquitin

ubiquitin: Ubiquitin family (462 - 530)

ubiquitin

ubiquitin: Ubiquitin family (538 - 606)

ubiquitin

ubiquitin: Ubiquitin family (614 - 682)

  • 0
  • 200
  • 400
  • 600
  • 685 a.a.
蛋白主名 其他名称

polyubiquitin-C

UBC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra UBC P0CG48 BUB1B Homo sapiens O60566
Anti Tag CoIP
19407811
Intra UBC P0CG48 MALT1 Homo sapiens Q9UDY8
Anti Tag CoIP
17948050
Intra UBC P0CG48 UBE2G2 Homo sapiens P60604
Validated Y2H
32296183
Intra UBC P0CG48 UBE2G2 Homo sapiens P60604
Y2H Array
32296183
Intra UBC P0CG48 UBE2G2 Homo sapiens P60604
Y2H Prey Pooling
32296183
Intra UBC P0CG48 UBE3A Homo sapiens Q05086-3
Y2H Array
32296183
Intra UBC P0CG48 UBE3A Homo sapiens Q05086-3
Y2H Prey Pooling
32296183
Intra UBC P0CG48 UBE3A Homo sapiens Q05086-3
Validated Y2H
32296183
Intra UBC P0CG48 FAM168A Homo sapiens Q92567-2
Validated Y2H
32296183
Intra UBC P0CG48 MTURN Homo sapiens Q8N3F0
Validated Y2H
32296183
Intra UBC P0CG48 EPN2 Homo sapiens O95208-2
Y2H Array
32296183
Intra UBC P0CG48 EPN2 Homo sapiens O95208-2
Y2H Prey Pooling
32296183
Intra UBC P0CG48 LCK Homo sapiens P06239
NMR
18539162
Intra UBC P0CG48 PRKCA Homo sapiens P17252
Anti Tag CoIP
18566587
Cross UBC P0CG48 RAD23 Saccharomyces cerevisiae P32628
Pull Down
20059542
Intra UBC P0CG48 ABCG2 Homo sapiens Q9UNQ0
Anti Bait CoIP
19909340
Intra UBC P0CG48 NPLOC4 Homo sapiens Q8TAT6
Anti Tag CoIP
35271311
Intra UBC P0CG48 NPLOC4 Homo sapiens Q8TAT6
ITC
17070805
Intra UBC P0CG48 BMI1 Homo sapiens P35226
Pull Down
20601937
Intra UBC P0CG48 YOD1 Homo sapiens Q5VVQ6
Validated Y2H
32296183
Cross UBC P0CG48 P0C6X7-PRO_0000037311 Human SARS coronavirus P0C6X7-PRO_0000037311
Cleavage
32726803
Cross UBC P0CG48 P0C6X7-PRO_0000037311 Human SARS coronavirus P0C6X7-PRO_0000037311
Probe Interaction
32726803
Cross UBC P0CG48 P0DTD1-PRO_0000449621 SARS-CoV-2 P0DTD1-PRO_0000449621
Probe Interaction
32726803
Cross UBC P0CG48 P0DTD1-PRO_0000449621 SARS-CoV-2 P0DTD1-PRO_0000449621
Cleavage
32726803
Intra UBC P0CG48 DESI1 Homo sapiens Q6ICB0
Validated Y2H
32296183
Intra UBC P0CG48 POLH Homo sapiens Q9Y253
Y2H
16763556
Intra UBC P0CG48 POLH Homo sapiens Q9Y253
Pull Down
16763556
Intra UBC P0CG48 CDIP1 Homo sapiens Q9H305
Validated Y2H
32296183
Intra UBC P0CG48 SENP3 Homo sapiens Q9H4L4
Pull Down
19680224
Intra UBC P0CG48 SQSTM1 Homo sapiens Q13501
Pull Down
12857745
Intra UBC P0CG48 SQSTM1 Homo sapiens Q13501
Pull Down
8702753
Intra UBC P0CG48 SQSTM1 Homo sapiens Q13501
Pull Down
19427866
Intra UBC P0CG48 NFKBIA Homo sapiens P25963
Anti Bait CoIP
17318178
Intra UBC P0CG48 NFKBIA Homo sapiens P25963
Anti Tag CoIP
17318178
Intra UBC P0CG48 NFKBIA Homo sapiens P25963
Pull Down
18539148
Intra UBC P0CG48 ASAP2 Homo sapiens O43150
Pull Down
17255943
Intra UBC P0CG48 SH3KBP1 Homo sapiens Q96B97
NMR
19111555
Intra UBC P0CG48 SH3KBP1 Homo sapiens Q96B97
NMR
18680311
Intra UBC P0CG48 ASAP1 Homo sapiens Q9ULH1
Pull Down
17255943
Intra UBC P0CG48 ASAP1 Homo sapiens Q9ULH1
Anti Tag CoIP
17255943
Intra UBC P0CG48 PARP1 Homo sapiens P09874
Anti Bait CoIP
19779455
Intra UBC P0CG48 PARP1 Homo sapiens P09874
Pull Down
19779455
Intra UBC P0CG48 MAP3K7 Homo sapiens O43318
Anti Tag CoIP
19820695
Intra UBC P0CG48 MAP3K7 Homo sapiens O43318
Pull Down
16845370
Intra UBC P0CG48 MAP3K7 Homo sapiens O43318
Anti Bait CoIP
19820695
Intra UBC P0CG48 TRAF6 Homo sapiens Q9Y4K3
Anti Bait CoIP
17703191
Intra UBC P0CG48 PSMD4 Homo sapiens P55036
Pull Down
20059542
Intra UBC P0CG48 PSMD4 Homo sapiens P55036
Pull Down
9488668
Intra UBC P0CG48 PSMD4 Homo sapiens P55036
Far-WB
8570649
Intra UBC P0CG48 PSMD4 Homo sapiens P55036
SPR
19798103
Intra UBC P0CG48 PSMD4 Homo sapiens P55036
Pull Down
19796170
Intra UBC P0CG48 TP53 Homo sapiens P04637
Anti Tag CoIP
17170702
Intra UBC P0CG48 TP53 Homo sapiens P04637
Anti Tag CoIP
17159902
Intra UBC P0CG48 TP53 Homo sapiens P04637
Pull Down
18566590
Intra UBC P0CG48 TP53 Homo sapiens P04637
Anti Bait CoIP
18309296
Intra UBC P0CG48 TP53 Homo sapiens P04637
Pull Down
17139261
Intra UBC P0CG48 TP53 Homo sapiens P04637
Anti Tag CoIP
17568776
Intra UBC P0CG48 TP53 Homo sapiens P04637
Pull Down
18388957
Intra UBC P0CG48 TP53 Homo sapiens P04637
Pull Down
19619542
Intra UBC P0CG48 TP53 Homo sapiens P04637
Anti Bait CoIP
18566590
Intra UBC P0CG48 TP53 Homo sapiens P04637
Anti Bait CoIP
17268548
Intra UBC P0CG48 PLEKHB2 Homo sapiens Q96CS7
Validated Y2H
32296183
Intra UBC P0CG48 ELAVL1 Homo sapiens Q15717
Anti Tag CoIP
19322201
Intra UBC P0CG48 MDM2 Homo sapiens Q00987
Anti Bait CoIP
18566590
Intra UBC P0CG48 MDM2 Homo sapiens Q00987
Pull Down
19166840
Intra UBC P0CG48 MDM2 Homo sapiens Q00987
Pull Down
18566590
Intra UBC P0CG48 MDM2 Homo sapiens Q00987
Anti Tag CoIP
19098711
Intra UBC P0CG48 GRK2 Homo sapiens P25098
Anti Bait CoIP
17006543
Intra UBC P0CG48 NFATC4 Homo sapiens Q14934
Anti Bait CoIP
19026640
Intra UBC P0CG48 NFATC4 Homo sapiens Q14934
Anti Tag CoIP
19026640
Intra UBC P0CG48 RDH12 Homo sapiens Q96NR8
Anti Tag CoIP
20006610
Intra UBC P0CG48 MYC Homo sapiens P01106
Anti Tag CoIP
19131971
Intra UBC P0CG48 MAP3K4 Homo sapiens Q9Y6R4
Anti Tag CoIP
16256071
Intra UBC P0CG48 MAP3K4 Homo sapiens Q9Y6R4
Anti Bait CoIP
16256071
Intra UBC P0CG48 HTT Homo sapiens P42858
Y2H Array
32814053
Intra UBC P0CG48 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra UBC P0CG48 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra UBC P0CG48 XIAP Homo sapiens P98170
Pull Down
17318174
Intra UBC P0CG48 XIAP Homo sapiens P98170
Anti Bait CoIP
17318174
Intra UBC P0CG48 XIAP Homo sapiens P98170
Anti Tag CoIP
17318174
Intra UBC P0CG48 TAX1BP1 Homo sapiens Q86VP1
Validated Y2H
32296183
Intra UBC P0CG48 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra UBC P0CG48 TAX1BP1 Homo sapiens Q86VP1
Pull Down
18239685
Intra UBC P0CG48 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
Intra UBC P0CG48 BCL2L12 Homo sapiens Q9HB09-1
Anti Tag CoIP
19376117
Intra UBC P0CG48 BCL2L12 Homo sapiens Q9HB09-1
Pull Down
19376117
Intra UBC P0CG48 NCK2 Homo sapiens O43639
NMR
18539162
Intra UBC P0CG48 DENR Homo sapiens O43583
Anti Tag CoIP
16936636
Intra UBC P0CG48 DENR Homo sapiens O43583
Anti Tag CoIP
16874301
Intra UBC P0CG48 DENR Homo sapiens O43583
Anti Bait CoIP
16936636
Intra UBC P0CG48 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra UBC P0CG48 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra UBC P0CG48 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra UBC P0CG48 CSF3R Homo sapiens Q99062
Anti Tag CoIP
17363902
Intra UBC P0CG48 CSF3R Homo sapiens Q99062
Pull Down
17363902
Intra UBC P0CG48 RELA Homo sapiens Q04206
Pull Down
17183367
Intra UBC P0CG48 RELA Homo sapiens Q04206
Anti Bait CoIP
17183367
Intra UBC P0CG48 RELA Homo sapiens Q04206
Anti Bait CoIP
19322197
Intra UBC P0CG48 RELA Homo sapiens Q04206
Pull Down
19322197
Intra UBC P0CG48 POLI Homo sapiens Q9UNA4
Y2H
16763556
Intra UBC P0CG48 NBR1 Homo sapiens Q14596
Pull Down
24879152
Intra UBC P0CG48 NBR1 Homo sapiens Q14596
Pull Down
19427866
Intra UBC P0CG48 NBR1 Homo sapiens Q14596
IF
19427866
Intra UBC P0CG48 UBAC1 Homo sapiens Q9BSL1
Validated Y2H
32296183
Intra UBC P0CG48 RYBP Homo sapiens Q8N488
ITC
17070805
Intra UBC P0CG48 STAM Homo sapiens Q92783
NMR
12750381
Intra UBC P0CG48 STAM Homo sapiens Q92783
SPR
12750381
Intra UBC P0CG48 STAM Homo sapiens Q92783
NMR
19111546
Intra UBC P0CG48 PLSCR4 Homo sapiens Q9NRQ2
Validated Y2H
32296183
Intra UBC P0CG48 DAXX Homo sapiens Q9UER7
Y2H Pooling
20936779
Intra UBC P0CG48 SNX9 Homo sapiens Q9Y5X1
Anti Tag CoIP
20491914
Intra UBC P0CG48 ZFAND5 Homo sapiens O76080
Anti Tag CoIP
16424905
Intra UBC P0CG48 ATXN3 Homo sapiens P54252-1
Anti Tag CoIP
19153604
Intra UBC P0CG48 ATXN3 Homo sapiens P54252-1
Anti Bait CoIP
19153604
Intra UBC P0CG48 ATXN3 Homo sapiens P54252-1
Pull Down
14559776
Intra UBC P0CG48 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra UBC P0CG48 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra UBC P0CG48 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra UBC P0CG48 ADRM1 Homo sapiens Q16186
Pull Down
20059542
Intra UBC P0CG48 RAD23B Homo sapiens P54727
Pull Down
20059542
Intra UBC P0CG48 RAD23B Homo sapiens P54727
Validated Y2H
32296183
Cross UBC P0CG48 Ikbkg Mus musculus O88522
Pull Down
19763089
Cross UBC P0CG48 rev Human immunodeficiency virus P04325
Pull Down
17067581
Cross UBC P0CG48 Rbck1 Rattus norvegicus Q62921
Anti Tag CoIP
19796170
Cross UBC P0CG48 Rbck1 Rattus norvegicus Q62921
Pull Down
19796170
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Phlyctenulosis

Phlyctenular Keratoconjunctivitis

Strumous Ophthalmia
Middle East Respiratory Syndrome

Mers

Mers - [Middle East Respiratory Syndrome]
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Paget'S Disease Of Bone

Osteitis Deformans

Paget Disease Of Bone

Osseous Paget'S Disease

Paget Disease Of Bone, Familial

Bone Paget Disease

Familial Paget'S Disease Of Bone

Paget'S Bone Disease

Familial Paget Disease Of Bone

Paget Disease, Bone

Pdb

Pagets Bone Disease
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Myoclonic Epilepsy Of Lafora

Lafora Disease

Epilepsy, Progressive Myoclonic 2b

EPM2

Melf

Epilepsy, Progressive Myoclonic 2a

Epm2a

Lafora'S Disease

Lafora Body Disease

Lbd

Epilepsy, Progressive Myoclonic, 2a

Lafora Progressive Myoclonic Epilepsy

Epilepsy Progressive Myoclonic 2

Lafora Body Disorder

Pme Type 2

Progressive Myoclonic Epilepsy Type 2

Progressive Myoclonus Epilepsy Type 2

Epilepsy, Progressive Myoclonic 2

Epm2b

Ld

Progressive Myoclonic Epilepsy 2

Progressive Myoclonic Epilepsy 2a

Progressive Myoclonic Epilepsy 2b

Progressive Myoclonic Epilepsy Lafora Type

Epilepsy, Myoclonic, Of Lafora
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
Ectodermal Dysplasia

Congenital Ectodermal Defect

Congenital Ectodermal Dysplasia

Ectodermal Dysplasia Syndrome

Dysplasia, Ectodermal
Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120934 C25-140 Inhibitor 99.86% 否
HY-13811 NSC697923 99.93% 否
HY-115453 UBCS039 Activator 99.06% 否
HY-124602 DI-591 Inhibitor 99.42% 否
HY-126075A WS-383 Inhibitor 99.88% 否
HY-145169 AZ194 Inhibitor 99.83% 否
HY-W264347 DCN1-UBC12-IN-4 Inhibitor ≥95.0% 否
HY-161470 WS-384 / 否
HY-126075 WS-383 free base Inhibitor / 否
HY-125660 Leucettamol A Inhibitor / 否
HY-131667 Hdm2 E3 ligase inhibitor 1 / 否
HY-142691 DCN1-UBC12-IN-1 Inhibitor / 否
HY-142692 DCN1-UBC12-IN-3 Inhibitor / 否
HY-142694 DCN1-UBC12-IN-2 Inhibitor / 否
HY-157728 ML307 Inhibitor / 否
HY-RS15334 UBC Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-111505A NAcM-OPT hydrochloride Inducer / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus UBC MGD MGI:98889
Rattus norvegicus UBC RGD RGD:621244
Bos taurus UBC VGNC VGNC:107263
Others UBC NCBI
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