BUB1B - BUB1 mitotic checkpoint serine/threonine kinase B Gene

中文名称：BUB1 有丝分裂检查点丝氨酸/苏氨酸激酶 B

种属: Homo sapiens

同用名: MVA1; SSK1; BUBR1; Bub1A; MAD3L; hBUBR1; BUB1beta

基因 ID: 701 | 基因类型: protein coding

关于 BUB1B

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,161,069-40,221,123 (from NCBI)

This gene has 11 transcripts (splice variants), 242 orthologues, 1 paralogue and is associated with 67 phenotypes. Biased expression in testis (RPKM 16.5), bone marrow (RPKM 7.5) and 12 other tissues.

功能概要

该基因编码参与纺锤体检查点功能的激酶。该蛋白质已定位于着丝粒，并在抑制后期促进复合物/细胞周期体 (APC/C) 、延迟后期开始并确保适当的染色体分离方面发挥作用。纺锤体检查点功能受损已在多种癌症中被发现。[RefSeq 提供，2008 年 7 月]

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of Cancer. [provided by RefSeq, Jul 2008]

BUB1B 基因产物(1)

mRNA	Protein	Name
NM_001211.6	NP_001202.5	mitotic checkpoint serine/threonine-protein kinase BUB1 beta

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9660858	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mitotic spindle assembly checkpoint signaling	IDA IDA: 通过直接分析推断	10477750	GOA
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: 通过突变表型推断	20220147	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	20220147	GOA
colocalizes with kinetochore	IDA IDA: 通过直接分析推断	12925705	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	9660858	GOA
part of mitotic checkpoint complex	IPI IPI: 通过物理相互作用推断	27509861	GOA
part of outer kinetochore	IDA IDA: 通过直接分析推断	19468067	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	20531406	GOA
located in spindle	IDA IDA: 通过直接分析推断	9763420	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BUB1B 蛋白结构

Mad3_BUB1_I

Pkinase

0
200
400
600
800
1050 a.a.

蛋白主名

其他名称

mitotic checkpoint serine/threonine-protein kinase BUB1 beta

BUB1B, mitotic checkpoint serine/threonine kinase

BUB1B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BUB1B	O60566	BUB3	Homo sapiens	O43684	Anti Tag CoIP	25852190
种属内	BUB1B	O60566	BUB3	Homo sapiens	O43684	Y2H	22000412
种属内	BUB1B	O60566	BUB3	Homo sapiens	O43684	Pull Down	25383541
种属内	BUB1B	O60566	BUB3	Homo sapiens	O43684	Anti Tag CoIP	19407811
种属内	BUB1B	O60566	BUB3	Homo sapiens	O43684	Anti Tag CoIP	35271311
种属内	BUB1B	O60566	BUB3	Homo sapiens	O43684	Anti Tag CoIP	22000412
种属内	BUB1B	O60566	BUB3	Homo sapiens	O43684	Pull Down	32707033
种属内	BUB1B	O60566	KNL1	Homo sapiens	Q8NG31-2	Y2H	22000412
种属内	BUB1B	O60566	CENPE	Homo sapiens	Q02224	Anti Tag CoIP	9763420
种属内	BUB1B	O60566	CENPE	Homo sapiens	Q02224	Y2H	9763420
种属间	BUB1B	O60566	Crebbp	Mus musculus	P45481	Anti Tag CoIP	24825348
种属内	BUB1B	O60566	UBC	Homo sapiens	P0CG48	Anti Tag CoIP	19407811
种属内	BUB1B	O60566	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	11030144
种属内	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Anti Tag CoIP	25383541
种属内	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Pull Down	25383541
种属内	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Anti Tag CoIP	22000412
种属内	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Y2H	11030144
种属内	BUB1B	O60566	CDC20	Homo sapiens	Q12834	GMS	21300909
种属内	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Anti Tag CoIP	25852190
种属内	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Pull Down	11030144
种属内	BUB1B	O60566	CDC20	Homo sapiens	Q12834	TAP	20360068
种属内	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	19407811
种属内	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Pull Down	32707033
种属内	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Protein Kinase Assay	11030144
种属内	BUB1B	O60566	CDC20	Homo sapiens	Q12834	Anti Tag CoIP	35271311
种属内	BUB1B	O60566	SIRT2	Homo sapiens	Q8IXJ6	Anti Tag CoIP	24825348
种属内	BUB1B	O60566	KAT2B	Homo sapiens	Q92831	IF	19407811
种属内	BUB1B	O60566	KAT2B	Homo sapiens	Q92831	Anti Bait CoIP	19407811
种属内	BUB1B	O60566	KAT2B	Homo sapiens	Q92831	Enzymatic Study	19407811
种属内	BUB1B	O60566	BUB1	Homo sapiens	O43683	Anti Tag CoIP	25852190
种属内	BUB1B	O60566	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	25852190
种属内	BUB1B	O60566	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	25383541
种属内	BUB1B	O60566	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	20212161
种属内	BUB1B	O60566	MAD2L1	Homo sapiens	Q13257	GMS	21300909
种属内	BUB1B	O60566	MAD2L1	Homo sapiens	Q13257	Pull Down	25383541
种属内	BUB1B	O60566	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	22000412

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Premature Chromatid Separation Trait

PCS	Total Premature Chromatid Separation Trait
Chromatid Separation Trait, Premature

Mosaic Variegated Aneuploidy Syndrome 1

Mva Syndrome	MVA1
Mosaic Variegated Aneuploidy Syndrome, Type 1	Mosaic Variegated Aneuploidy Syndrome
Congenital Chromosomal Disease

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome	Mva Syndrome
Mosaic Variegated Aneuplody Microcephaly Syndrome	Warburton Anyane Yeboa Syndrome

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Rhabdomyosarcoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Adrenal Cortical Carcinoma

Adrenocortical Carcinoma	Adrenal Cortex Carcinoma
Carcinoma Of The Adrenal Cortex	Acc
Adrenocortical Cancer	Carcinoma Adrenocortical

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01682	BUB1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-161865	Antitumor agent-180	Inducer	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	BUB1B	VGNC	VGNC:70293
Mus musculus	BUB1B	MGD	MGI:1333889
Canis familiaris	BUB1B	VGNC	VGNC:38566
Felis catus	BUB1B	VGNC	VGNC:81027
Bos taurus	BUB1B	VGNC	VGNC:26605
Rattus norvegicus	BUB1B	RGD	RGD:619791

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BUB1B - BUB1 mitotic checkpoint serine/threonine kinase B Gene

关于 BUB1B

功能概要

BUB1B 基因产物(1)

BUB1B 蛋白结构

BUB1B 蛋白互作信息

关联疾病

直系同源

热门区域

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BUB1B - BUB1 mitotic checkpoint serine/threonine kinase B Gene

关于 BUB1B

功能概要

BUB1B 基因产物(1)

BUB1B 蛋白结构

BUB1B 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

L

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Q

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