KAT2B - lysine acetyltransferase 2B Gene

中文名称：赖氨酸乙酰转移酶 2B

种属: Homo sapiens

同用名: CAF; PCAF; P/CAF

基因 ID: 8850 | 基因类型: protein coding

关于 KAT2B

Cytogenetic location: 3p24.3 Genomic coordinates (GRCh38): 3:20,040,446-20,154,404 (from NCBI)

This gene has 5 transcripts (splice variants), 219 orthologues and 11 paralogues. Ubiquitous expression in brain (RPKM 17.7), bone marrow (RPKM 16.3) and 25 other tissues.

功能概要

CBP 和 p300 是大型核蛋白，可与许多参与细胞生长和/或分化的序列特异性因子结合，包括 c-Jun 和腺病毒癌蛋白 E1A。该基因编码的蛋白质与 p300/CBP 相关。它与 CBP 和 p300 具有体外和体内结合活性，并与 E1A 竞争 p300/CBP 中的结合位点。它与核心组蛋白和核小体核心颗粒具有组蛋白乙酰转移酶活性，表明该蛋白在转录调控中起直接作用。[RefSeq 提供，2008 年 7 月]

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-Jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]

KAT2B 基因产物(3)

mRNA	Protein	Name
XM_005265528.5	XP_005265585.1	histone acetyltransferase KAT2B isoform X1
NM_003884.5	NP_003875.3	histone acetyltransferase KAT2B
XM_047449147.1	XP_047305103.1	histone acetyltransferase KAT2B isoform X2

KAT2B 蛋白结构

PCAF_N

Acetyltransf_7

Bromodomain

0
200
400
600
832 a.a.

蛋白主名

其他名称

histone acetyltransferase KAT2B

CREBBP-associated factor	K(lysine) acetyltransferase 2B
histone acetylase PCAF	histone acetyltransferase PCAF
p300/CBP-associated factor	spermidine acetyltransferase KAT2B

KAT2B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	KAT2B	Q92831	BUB1B	Homo sapiens	O60566	Enzymatic Study	19407811
种属内	KAT2B	Q92831	BUB1B	Homo sapiens	O60566	Anti Tag CoIP	19407811
种属内	KAT2B	Q92831	BUB1B	Homo sapiens	O60566	Anti Tag CoIP	24825348
种属内	KAT2B	Q92831	TWIST1	Homo sapiens	Q15672	Anti Tag CoIP	18504427
种属内	KAT2B	Q92831	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	19188449
种属间	KAT2B	Q92831	Tp63	Mus musculus	O88898-2	Acetylase Assay	22575646
种属间	KAT2B	Q92831	N	SARS-CoV-2	P0DTC9	Acetylase Assay	33894414
种属内	KAT2B	Q92831	HIF1A	Homo sapiens	Q16665	Anti Bait CoIP	16543236
种属内	KAT2B	Q92831	HIF1A	Homo sapiens	Q16665	Pull Down	16543236
种属内	KAT2B	Q92831	SIRT2	Homo sapiens	Q8IXJ6	Pull Down	12887892
种属内	KAT2B	Q92831	SIRT2	Homo sapiens	Q8IXJ6	Anti Tag CoIP	12887892
种属内	KAT2B	Q92831	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	KAT2B	Q92831	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	KAT2B	Q92831	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	KAT2B	Q92831	TAF9	Homo sapiens	Q16594	Anti Bait CoIP	9674425
种属内	KAT2B	Q92831	EHMT2	Homo sapiens	Q96KQ7	Anti Bait CoIP	24492005
种属内	KAT2B	Q92831	EHMT2	Homo sapiens	Q96KQ7	Anti Tag CoIP	24492005
种属内	KAT2B	Q92831	CREBBP	Homo sapiens	Q92793	Pull Down	8684459
种属内	KAT2B	Q92831	CREBBP	Homo sapiens	Q92793	Anti Bait CoIP	8684459
种属内	KAT2B	Q92831	CREBBP	Homo sapiens	Q92793	Pull Down	9687513
种属间	KAT2B	Q92831	E7	Human papillomavirus	P03129	Y2H	12813456
种属间	KAT2B	Q92831	E7	Human papillomavirus	P03129	Anti Bait CoIP	12163591
种属间	KAT2B	Q92831	e1a_ade05	Human adenovirus C	P03255	Y2H	9687513
种属间	KAT2B	Q92831	e1a_ade05	Human adenovirus C	P03255	Pull Down	9687513

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Spinocerebellar Ataxia 7

Spinocerebellar Ataxia Type 7	SCA7
Opca3	Opca Iii
Olivopontocerebellar Atrophy Iii	Opca With Retinal Degeneration
Opca With Macular Degeneration And External Ophthalmoplegia	Adca, Type Ii
Autosomal Dominant Cerebellar Ataxia Type 2	Olivopontocerebellar Atrophy 3
Autosomal Dominant Cerebellar Ataxia, Type Ii	Autosomal Dominant Cerebellar Ataxia Type Ii
Adca2	Adcaii
Ataxia With Pigmentary Retinopathy	Cerebellar Syndrome-Pigmentary Maculopathy Syndrome
Olivopontocerebellar Atrophy With Retinal Degeneration	Spinocerebellar Ataxia-7
Ataxia, Spinocerebellar, Type 7

Rhabdomyosarcoma

Chromosome 16p13.3 Deletion Syndrome, Proximal

Rubinstein-Taybi Syndrome	Broad Thumb-Hallux Syndrome
Chromosome 16p13.3 Deletion Syndrome	Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion
Rubinstein Syndrome	Broad Thumbs-Halluces Syndrome
Rsts	Rubinstein-Taybi Deletion Syndrome
Rsts Deletion Syndrome	Proximal Chromosome 16p13.3 Deletion Syndrome
16p13.3 Deletion Syndrome	Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation
Rts

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-W015239	KAT8-IN-1		99.40%	否
HY-RS07077	KAT2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07078	Kat2b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07079	KAT2B Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	KAT2B	VGNC	VGNC:42210
Rattus norvegicus	KAT2B	RGD	RGD:1305902
Felis catus	KAT2B	VGNC	VGNC:68709
Macaca mulatta	KAT2B	VGNC	VGNC:74036
Mus musculus	KAT2B	MGD	MGI:1343094
Bos taurus	KAT2B	VGNC	VGNC:30399
Others	KAT2B	NCBI

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