SIRT2 - sirtuin 2 Gene

中文名称：沉默信息调节因子 2 相关酶类 2

种属: Homo sapiens

同用名: SIR2; SIR2L; SIR2L2

基因 ID: 22933 | 基因类型: protein coding

关于 SIRT2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,878,555-38,899,618 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 187 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 37.1), ovary (RPKM 15.7) and 25 other tissues.

功能概要

该基因编码沉默信息调节因子 2 相关酶类蛋白家族的成员，与酵母 Sir2 蛋白同源。沉默信息调节因子 2 相关酶类家族的成员以沉默信息调节因子 2 相关酶类核心域为特征，分为四类。人类沉默信息调节因子 2 相关酶类 s 的功能尚未确定；然而，已知酵母沉默信息调节因子 2 相关酶类蛋白可调节表观遗传基因沉默并抑制 rDNA 的重组。研究表明，人类沉默信息调节因子 2 相关酶类 s 可能作为具有单 ADP 核糖基转移酶活性的细胞内调节蛋白发挥作用。由该基因编码的蛋白质属于沉默信息调节因子 2 相关酶类家族的 I 类。该基因的选择性剪接产生了几种转录本变体。[RefSeq 提供，2010 年 7 月]

This gene encodes a member of the Sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast Sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the Sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]

SIRT2 基因产物(7)

mRNA	Protein	Name
NM_001193286.2	NP_001180215.1	NAD-dependent protein deacetylase sirtuin-2 isoform 3
XM_047438469.1	XP_047294425.1	NAD-dependent protein deacetylase sirtuin-2 isoform X3
NM_030593.3	NP_085096.1	NAD-dependent protein deacetylase sirtuin-2 isoform 2
XM_047438468.1	XP_047294424.1	NAD-dependent protein deacetylase sirtuin-2 isoform X1
NR_034146.1
XM_011526655.2	XP_011524957.1	NAD-dependent protein deacetylase sirtuin-2 isoform X2
NM_012237.4	NP_036369.2	NAD-dependent protein deacetylase sirtuin-2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	12887892	GOA
enables NAD+ binding	IDA IDA: 通过直接分析推断	11427894	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: 通过直接分析推断	10381378	GOA
enables NAD-dependent histone H4K16 deacetylase activity	IDA IDA: 通过直接分析推断	16648462	GOA
NOT enables NAD-dependent histone deacetylase activity	IDA IDA: 通过直接分析推断	24177535	GOA
enables NAD-dependent histone deacetylase activity	IDA IDA: 通过直接分析推断	11427894	GOA
enables NAD-dependent protein demyristoylase activity	IDA IDA: 通过直接分析推断	25704306	GOA
enables NAD-dependent protein depalmitoylase activity	IDA IDA: 通过直接分析推断	32103017	GOA
enables NAD-dependent protein lysine deacetylase activity	IDA IDA: 通过直接分析推断	18722353	GOA
enables NAD-dependent protein lysine deacetylase activity	IMP IMP: 通过突变表型推断	24681946	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	23908241	GOA
enables histone acetyltransferase binding	IPI IPI: 通过物理相互作用推断	12887892	GOA
enables histone deacetylase activity	IDA IDA: 通过直接分析推断	17488717	GOA
enables histone deacetylase binding	IPI IPI: 通过物理相互作用推断	12620231	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12697818	GOA
enables protein lysine deacetylase activity	IDA IDA: 通过直接分析推断	17172643	GOA
enables protein lysine deacetylase activity	IMP IMP: 通过突变表型推断	23908241	GOA
NOT enables tubulin deacetylase activity	IDA IDA: 通过直接分析推断	24177535	GOA
enables tubulin deacetylase activity	IDA IDA: 通过直接分析推断	12620231	GOA
enables ubiquitin binding	IDA IDA: 通过直接分析推断	12697818	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	11427894	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to hypoxia	IDA IDA: 通过直接分析推断	24681946	GOA
involved in epigenetic regulation of gene expression	IMP IMP: 通过突变表型推断	23908241	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12887892	GOA
involved in negative regulation of autophagy	IMP IMP: 通过突变表型推断	20543840	GOA
involved in negative regulation of protein catabolic process	IMP IMP: 通过突变表型推断	20543840	GOA
involved in negative regulation of striated muscle tissue development	IDA IDA: 通过直接分析推断	12887892	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	18722353	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	24681946	GOA
involved in peptidyl-lysine deacetylation	IDA IDA: 通过直接分析推断	23932781	GOA
involved in positive regulation of fatty acid biosynthetic process	IDA IDA: 通过直接分析推断	23932781	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	24681946	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	21841822	GOA
NOT involved in protein deacetylation	IDA IDA: 通过直接分析推断	24177535	GOA
involved in protein deacetylation	IDA IDA: 通过直接分析推断	20543840	GOA
involved in regulation of cell cycle	IMP IMP: 通过突变表型推断	17726514	GOA
NOT involved in tubulin deacetylation	IDA IDA: 通过直接分析推断	24177535	GOA
involved in tubulin deacetylation	IDA IDA: 通过直接分析推断	18722353	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centriole	IDA IDA: 通过直接分析推断	17726514	GOA
located in centrosome	IDA IDA: 通过直接分析推断	17488717	GOA
located in chromosome	IDA IDA: 通过直接分析推断	16648462	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	12697818	GOA
located in cytosol	IDA IDA: 通过直接分析推断	24681946	GOA
located in microtubule	IDA IDA: 通过直接分析推断	12620231	GOA
located in midbody	IDA IDA: 通过直接分析推断	17726514	GOA
located in mitotic spindle	IDA IDA: 通过直接分析推断	17488717	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15213244	GOA
located in spindle	IDA IDA: 通过直接分析推断	17726514	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SIRT2 蛋白结构

SIR2

0
100
200
300
389 a.a.

蛋白主名

其他名称

NAD-dependent protein deacetylase sirtuin-2

NAD-dependent deacetylase sirtuin-2	NAD-dependent protein defatty-acylase sirtuin-2
SIR2-like protein 2	regulatory protein SIR2 homolog 2
silent information regulator 2	sir2-related protein type 2
sirtuin type 2

SIRT2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SIRT2	Q8IXJ6	BUB1B	Homo sapiens	O60566	Anti Bait CoIP	24825348
Intra	SIRT2	Q8IXJ6	SHANK3	Homo sapiens	Q9BYB0	Anti Tag CoIP	21653829
Intra	SIRT2	Q8IXJ6	SHANK3	Homo sapiens	Q9BYB0	Y2H Pooling	21653829
Intra	SIRT2	Q8IXJ6	G6PD	Homo sapiens	P11413	Anti Tag CoIP	24769394
Intra	SIRT2	Q8IXJ6	KAT2B	Homo sapiens	Q92831	Anti Tag CoIP	12887892
Intra	SIRT2	Q8IXJ6	RELA	Homo sapiens	Q04206	Anti Bait CoIP	21081649

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Wallerian Degeneration

Wallerian Degeneration Of The Pyramidal Tract

Monckeberg Arteriosclerosis

Monckeberg Medial Calcific Sclerosis

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-B0150	Nicotinamide	Inhibitor	99.99%	是
HY-B0879A	Suramin sodium salt	Inhibitor	99.48%	是
HY-B0879	Suramin	Inhibitor	/	否
HY-B0150A	Nicotinamide Hydrochloride	Inhibitor	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-10532	SRT 1720	Activator	99.90%	否
HY-107454	OSS_128167	Inhibitor	98.63%	否
HY-100578	AGK2	Inhibitor	99.62%	否
HY-15145	SRT 1720 monohydrochloride	Activator	99.92%	否
HY-13515	Sirtinol	Inhibitor	≥98.0%	否
HY-101278	Thiomyristoyl	Inhibitor	99.74%	否
HY-100591	SirReal2	Inhibitor	≥99.0%	否
HY-16691	AK-7	Inhibitor	99.93%	否
HY-100732	Cambinol	Inhibitor	99.89%	否
HY-15510	Tenovin-6	Inhibitor	98.33%	否
HY-101073	Salermide	Inhibitor	≥98.0%	否
HY-136199	SIRT1-IN-1	Inhibitor	98.19%	否
HY-103636	PROTAC Sirt2 Degrader-1	Inhibitor	98.71%	否
HY-N1926	Dihydrocoumarin	Inhibitor	99.81%	否
HY-101465	AK-1	Inhibitor	99.97%	否
HY-16616	SIRT-IN-2	Inhibitor	98.08%	否
HY-146689	SIRT1-IN-2	Inhibitor	98.86%	否
HY-15510B	Tenovin-6 Hydrochloride	Inhibitor	98.88%	否
HY-107660	SIRT2-IN-8	Inhibitor	99.32%	否
HY-B0150R	Nicotinamide (Standard)	Inhibitor	99.85%	否
HY-151519	SIRT2-IN-9	Inhibitor	99.45%	否
HY-112427	Sirt2-IN-1	Inhibitor	98.71%	否
HY-16615	SIRT-IN-1	Inhibitor	98.58%	否
HY-146690	SIRT1-IN-3	Inhibitor	99.18%	否
HY-148408	SIRT2-IN-11	Inhibitor	99.94%	否
HY-147233	MIND4-19	Inhibitor	99.94%	否
HY-111522	RK-9123016	Inhibitor	99.02%	否
HY-111329	JGB1741	Inhibitor	99.05%	否
HY-111303	CHIC35	Inhibitor	/	否
HY-160617	SIRT2-IN-14	Inhibitor	/	否
HY-145958	Sirt2-IN-6	Inhibitor	/	否
HY-118343	AC-93253	Inhibitor	/	否
HY-163532	FLS-359	Modulator	/	否
HY-149637	HSP70/SIRT2-IN-1	Inhibitor	/	否
HY-123653	SirReal-1	Inhibitor	/	否
HY-160944	hsa62	Inhibitor	/	否
HY-150727	SIRT5 inhibitor 4	Inhibitor	/	否
HY-115979	Sirt2-IN-5	Inhibitor	/	否
HY-146013	Sirt1/2-IN-1	Inhibitor	/	否
HY-W841840	SR94	Inhibitor	/	否
HY-156027	SIRT6-IN-3	Inhibitor	/	否
HY-119889	A1B11	Inhibitor	/	否
HY-117442	A2B57	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SIRT2	VGNC	VGNC:34631
Felis catus	SIRT2	VGNC	VGNC:65156
Canis familiaris	SIRT2	VGNC	VGNC:53983
Rattus norvegicus	SIRT2	RGD	RGD:621481
Macaca mulatta	SIRT2	VGNC	VGNC:77219
Mus musculus	SIRT2	MGD	MGI:1927664
Others	SIRT2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SIRT2 - sirtuin 2 Gene

关于 SIRT2

功能概要

SIRT2 基因产物(7)

SIRT2 蛋白结构

SIRT2 蛋白互作信息

关联疾病

直系同源

热门区域

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SIRT2 - sirtuin 2 Gene

关于 SIRT2

功能概要

SIRT2 基因产物(7)

SIRT2 蛋白结构

SIRT2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z