1. Cell Cycle/DNA Damage Epigenetics
  2. Sirtuin
  3. SIRT5 inhibitor 4

SIRT5 inhibitor 4 (compound 11) 是一种有效的选择性 SIRT5 抑制剂,抑制 SIRT5 和其他 SIRT 亚型的IC50 值分别为 26.4 μM 和 >400 μM。

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SIRT5 inhibitor 4 Chemical Structure

SIRT5 inhibitor 4 Chemical Structure

CAS No. : 708992-34-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SIRT5 inhibitor 4 (compound 11) is a potent, selective SIRT5 inhibitor with IC50 values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively[1].

IC50 & Target[1]

SIRT5

26.4 μM (IC50)

SIRT1

>400 μM (IC50)

SIRT2

>400 μM (IC50)

SIRT3

>400 μM (IC50)

SIRT6

>400 μM (IC50)

SIRT7

>400 μM (IC50)

体外研究
(In Vitro)

SIRT5 inhibitor 4 (compound 11) (6-200 µM) stabilizes SIRT5 protein with a temperature shift of 1.8℃ in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

369.39

Formula

C18H15N3O4S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SIRT5 inhibitor 4
目录号:
HY-150727
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