BUB1 - BUB1 mitotic checkpoint serine/threonine kinase Gene

中文名称：BUB1 有丝分裂检查点丝氨酸/苏氨酸激酶

种属: Homo sapiens

同用名: BUB1A; BUB1L; hBUB1

基因 ID: 699 | 基因类型: protein coding

关于 BUB1

Cytogenetic location: 2q13 Genomic coordinates (GRCh38): 2:110,637,528-110,678,063 (from NCBI)

This gene has 14 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in testis (RPKM 25.2), lymph node (RPKM 11.3) and 10 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶，在有丝分裂中起着重要作用。编码的蛋白质部分通过磷酸化有丝分裂检查点复合体的成员和激活纺锤体检查点来发挥作用。这种蛋白质还在抑制后期促进复合物/细胞周期体的激活中发挥作用。这种蛋白质也可能在 DNA 损伤反应中发挥作用。该基因的突变与非整倍体和几种癌症有关。交替剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of Cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

BUB1 基因产物(3)

mRNA	Protein	Name
NM_001278616.2	NP_001265545.1	mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 2
NM_001278617.2	NP_001265546.1	mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 3
NM_004336.5	NP_004327.1	mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables histone H2A kinase activity	IDA IDA: 通过直接分析推断	26658523	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10198256	GOA
enables protein kinase activity	IDA IDA: 通过直接分析推断	18995837	GOA
enables protein kinase activity	IMP IMP: 通过突变表型推断	22331848	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	25308863	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: 通过突变表型推断	18995837	GOA
involved in positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric	IMP IMP: 通过突变表型推断	25308863	GOA
involved in regulation of chromosome segregation	IMP IMP: 通过突变表型推断	19487456	GOA
involved in regulation of sister chromatid cohesion	IDA IDA: 通过直接分析推断	15723797	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in kinetochore	IDA IDA: 通过直接分析推断	15020684	GOA
part of outer kinetochore	IDA IDA: 通过直接分析推断	22331848	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BUB1 蛋白结构

Mad3_BUB1_I

Pkinase

0
200
400
600
800
1000
1085 a.a.

蛋白主名

其他名称

mitotic checkpoint serine/threonine-protein kinase BUB1

BUB1 budding uninhibited by benzimidazoles 1 homolog

BUB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BUB1	O43683	KNL1	Homo sapiens	Q8NG31	Anti Tag CoIP	33961781
种属内	BUB1	O43683	KNL1	Homo sapiens	Q8NG31	TAP	20360068
种属内	BUB1	O43683	KNL1	Homo sapiens	Q8NG31	Anti Bait CoIP	22660415
种属内	BUB1	O43683	BUB1B	Homo sapiens	O60566	Y2H Array	31515488
种属内	BUB1	O43683	BUB1B	Homo sapiens	O60566	Anti Tag CoIP	33961781
种属内	BUB1	O43683	BUB1B	Homo sapiens	O60566	TAP	20360068
种属内	BUB1	O43683	BUB3	Homo sapiens	O43684	Y2H Array	25416956
种属内	BUB1	O43683	BUB3	Homo sapiens	O43684	Y2H Array	21988832
种属内	BUB1	O43683	BUB3	Homo sapiens	O43684	Anti Tag CoIP	33961781
种属内	BUB1	O43683	KNL1	Homo sapiens	Q8NG31-2	Anti Tag CoIP	26496610
种属内	BUB1	O43683	KNL1	Homo sapiens	Q8NG31-2	Anti Tag CoIP	28514442
种属内	BUB1	O43683	KNL1	Homo sapiens	Q8NG31-2	Y2H	19141287
种属内	BUB1	O43683	ARIH2	Homo sapiens	O95376	Y2H Pooling	16189514
种属内	BUB1	O43683	ARIH2	Homo sapiens	O95376	Y2H Array	31515488
种属内	BUB1	O43683	ARIH2	Homo sapiens	O95376	Validated Y2H	32296183
种属内	BUB1	O43683	CRK	Homo sapiens	P46108	Y2H Pooling	16189514

种属间: 跨种属相互作用 种属内: 同种属相互作用

BUB1 抗体

目录号	产品名	应用	反应物种
HY-P81822	BUB1 Antibody (YA1567)	WB, IHC-P	Human, Mouse, Rat

关联疾病

疾病名称

别名

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome	Mva Syndrome
Mosaic Variegated Aneuplody Microcephaly Syndrome	Warburton Anyane Yeboa Syndrome

Polyploidy

Polyploid

Polyploidy Syndrome

Prostate Carcinoma In Situ

Carcinoma In Situ Of Prostate	Grade Iii Pin
Pin Iii

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-103020	BAY-1816032	Inhibitor	99.05%	否
HY-104001	BAY-524	Inhibitor	99.48%	否
HY-102081	2OH-BNPP1		99.65%	否
HY-104000	BAY-320	Inhibitor	99.74%	否
HY-RS01681	BUB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01682	BUB1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-161865	Antitumor agent-180	Inducer	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	BUB1	VGNC	VGNC:26604
Felis catus	BUB1	VGNC	VGNC:60210
Macaca mulatta	BUB1	VGNC	VGNC:70292
Mus musculus	BUB1	MGD	MGI:1100510
Canis familiaris	BUB1	VGNC	VGNC:38565
Rattus norvegicus	BUB1	RGD	RGD:1311707
Others	BUB1	NCBI

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沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BUB1 - BUB1 mitotic checkpoint serine/threonine kinase Gene

关于 BUB1

功能概要

BUB1 基因产物(3)

BUB1 蛋白结构

BUB1 蛋白互作信息

BUB1 抗体

关联疾病

直系同源

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BUB1 - BUB1 mitotic checkpoint serine/threonine kinase Gene

关于 BUB1

功能概要

BUB1 基因产物(3)

BUB1 蛋白结构

BUB1 蛋白互作信息

BUB1 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z