CRK - CRK proto-oncogene, adaptor protein Gene

中文名称：CRK 原癌基因、衔接蛋白

种属: Homo sapiens

同用名: p38; CRKII

基因 ID: 1398 | 基因类型: protein coding

关于 CRK

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,420,693-1,456,232 (from NCBI)

This gene has 4 transcripts (splice variants), 266 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 27.5), thyroid (RPKM 27.2) and 25 other tissues.

功能概要

该基因编码衔接蛋白家族的一个成员，该家族可与多种酪氨酸磷酸化蛋白结合。该基因的产物具有多个 SH2 和 SH3 结构域 (src-同源结构域) ，并参与多个信号通路，通过 SH2-磷酸酪氨酸相互作用在酪氨酸激酶附近募集细胞质蛋白。该蛋白的 N 端 SH2 结构域作为转化的正调节因子发挥作用，而 C 端 SH3 结构域作为转化的负调节因子发挥作用。已经描述了编码具有不同生物活性的不同亚型的两种替代转录本。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

CRK 基因产物(2)

mRNA	Protein	Name
NM_005206.5	NP_005197.3	adapter molecule crk isoform b
NM_016823.4	NP_058431.2	adapter molecule crk isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables SH2 domain binding	IPI IPI: 通过物理相互作用推断	9472046	GOA
enables SH3 domain binding	IPI IPI: 通过物理相互作用推断	12384576	GOA
enables ephrin receptor binding	IPI IPI: 通过物理相互作用推断	11870224	GOA
enables kinase binding	IPI IPI: 通过物理相互作用推断	18722344	GOA
enables phosphotyrosine residue binding	IPI IPI: 通过物理相互作用推断	20624904	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7561682	GOA
enables protein phosphorylated amino acid binding	IDA IDA: 通过直接分析推断	12384576	GOA
enables protein tyrosine kinase binding	IPI IPI: 通过物理相互作用推断	12384576	GOA
enables signaling adaptor activity	IDA IDA: 通过直接分析推断	12384576	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in actin cytoskeleton organization	IMP IMP: 通过突变表型推断	31311869	GOA
involved in ephrin receptor signaling pathway	IDA IDA: 通过直接分析推断	11870224	GOA
involved in negative regulation of cell motility	IDA IDA: 通过直接分析推断	17515907	GOA
involved in negative regulation of cell motility	IMP IMP: 通过突变表型推断	17515907	GOA
involved in negative regulation of wound healing	IDA IDA: 通过直接分析推断	17515907	GOA
involved in negative regulation of wound healing	IMP IMP: 通过突变表型推断	17515907	GOA
involved in positive regulation of cell growth	IDA IDA: 通过直接分析推断	17515907	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: 通过突变表型推断	19004829	GOA
involved in regulation of GTPase activity	IDA IDA: 通过直接分析推断	11870224	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: 通过直接分析推断	11870224	GOA
NOT involved in regulation of cell motility	IDA IDA: 通过直接分析推断	17515907	GOA
involved in regulation of cell shape	IMP IMP: 通过突变表型推断	17515907	GOA
involved in regulation of intracellular signal transduction	IDA IDA: 通过直接分析推断	12384576	GOA
involved in regulation of signal transduction	IDA IDA: 通过直接分析推断	17515907	GOA
NOT involved in regulation of wound healing	IDA IDA: 通过直接分析推断	17515907	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of protein-containing complex	IPI IPI: 通过物理相互作用推断	12384576	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRK 蛋白结构

SH2

SH3_1

SH3_2

0
100
200
304 a.a.

蛋白主名

其他名称

adapter molecule crk

proto-oncogene c-Crk

CRK 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CRK	P46108	ABL2	Homo sapiens	P42684	Protein Kinase Assay	15886098
种属内	CRK	P46108	ABL2	Homo sapiens	P42684	Anti Tag CoIP	33961781
种属内	CRK	P46108	ABL2	Homo sapiens	P42684	TAP	19380743
种属内	CRK	P46108	FLACC1	Homo sapiens	Q96Q35-2	Y2H Prey Pooling	26871637
种属内	CRK	P46108	FLACC1	Homo sapiens	Q96Q35-2	Validated Y2H	26871637
种属内	CRK	P46108	FLACC1	Homo sapiens	Q96Q35-2	Y2H Array	26871637
种属内	CRK	P46108	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	26871637
种属内	CRK	P46108	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	26871637
种属内	CRK	P46108	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	26871637
种属内	CRK	P46108	MAP4K5	Homo sapiens	Q9Y4K4	Pull Down	9788432
种属内	CRK	P46108	MAP4K5	Homo sapiens	Q9Y4K4	TAP	19380743
种属内	CRK	P46108	MAP4K5	Homo sapiens	Q9Y4K4	CoIP	9788432
种属内	CRK	P46108	KIT	Homo sapiens	P10721	FPS	24728074
种属内	CRK	P46108	RIN3	Homo sapiens	Q8TB24	Y2H Array	25814554
种属内	CRK	P46108	BICRA	Homo sapiens	Q9NZM4	Phage Display	35044719
种属内	CRK	P46108	ELK3	Homo sapiens	P41970	BiFC	26871637
种属内	CRK	P46108	ELK3	Homo sapiens	P41970	Y2H Prey Pooling	26871637
种属内	CRK	P46108	ELK3	Homo sapiens	P41970	Y2H Array	26871637
种属内	CRK	P46108	ELK3	Homo sapiens	P41970	Validated Y2H	26871637
种属内	CRK	P46108	DOCK5	Homo sapiens	Q9H7D0	Anti Tag CoIP	31980649
种属内	CRK	P46108	DOCK5	Homo sapiens	Q9H7D0	Phage Display	35044719
种属内	CRK	P46108	DOCK5	Homo sapiens	Q9H7D0	Anti Tag CoIP	33961781
种属内	CRK	P46108	ASAP3	Homo sapiens	Q8TDY4	Y2H Prey Pooling	26871637
种属内	CRK	P46108	ASAP3	Homo sapiens	Q8TDY4	Anti Tag CoIP	33961781
种属内	CRK	P46108	ASAP3	Homo sapiens	Q8TDY4	Validated Y2H	26871637
种属内	CRK	P46108	ASAP3	Homo sapiens	Q8TDY4	BiFC	26871637
种属内	CRK	P46108	ASAP3	Homo sapiens	Q8TDY4	Y2H Array	26871637
种属内	CRK	P46108	ASAP3	Homo sapiens	Q8TDY4	TAP	19380743
种属内	CRK	P46108	PDGFRA	Homo sapiens	P16234	Enzymatic Study	9546424
种属内	CRK	P46108	PDGFRA	Homo sapiens	P16234	Pull Down	10733900
种属内	CRK	P46108	EGFR	Homo sapiens	P00533	Protein Array	16273093
种属内	CRK	P46108	SOS1	Homo sapiens	Q07889	Anti Tag CoIP	31980649
种属内	CRK	P46108	SOS1	Homo sapiens	Q07889	Anti Tag CoIP	33961781
种属内	CRK	P46108	SOS1	Homo sapiens	Q07889	TAP	19380743
种属内	CRK	P46108	SOS2	Homo sapiens	Q07890	Anti Tag CoIP	33961781
种属内	CRK	P46108	SOS2	Homo sapiens	Q07890	Peptide Array	17474147
种属内	CRK	P46108	SOS2	Homo sapiens	Q07890	TAP	19380743
种属内	CRK	P46108	ARHGAP32	Homo sapiens	A7KAX9	Anti Tag CoIP	31980649
种属内	CRK	P46108	ARHGAP32	Homo sapiens	A7KAX9	Phage Display	35044719
种属内	CRK	P46108	GAREM1	Homo sapiens	Q9H706	Validated Y2H	25814554
种属内	CRK	P46108	GAREM1	Homo sapiens	Q9H706	Phage Display	35044719
种属内	CRK	P46108	ASAP1	Homo sapiens	Q9ULH1	Anti Tag CoIP	33961781
种属内	CRK	P46108	ASAP1	Homo sapiens	Q9ULH1	Anti Tag CoIP	31980649
种属内	CRK	P46108	ASAP1	Homo sapiens	Q9ULH1	Peptide Array	17474147
种属内	CRK	P46108	FLNA	Homo sapiens	P21333	Peptide Array	17474147
种属内	CRK	P46108	FLNA	Homo sapiens	P21333	PLA	25241761
种属内	CRK	P46108	IRS4	Homo sapiens	O14654	Pull Down	11316748
种属内	CRK	P46108	IRS4	Homo sapiens	O14654	CoIP	11316748
种属内	CRK	P46108	PSMC6	Homo sapiens	P62333	Y2H Prey Pooling	26871637
种属内	CRK	P46108	PSMC6	Homo sapiens	P62333	Validated Y2H	26871637
种属内	CRK	P46108	PSMC6	Homo sapiens	P62333	Y2H Array	26871637
种属内	CRK	P46108	PSMC6	Homo sapiens	P62333	Validated Y2H	32296183
种属内	CRK	P46108	PSMC6	Homo sapiens	P62333	Y2H Pooling	16189514
种属内	CRK	P46108	ABL1	Homo sapiens	P00519	Anti Tag CoIP	33961781
种属内	CRK	P46108	ABL1	Homo sapiens	P00519	Anti Tag CoIP	31980649
种属内	CRK	P46108	SAXO1	Homo sapiens	Q8IYX7	Validated Y2H	25416956
种属内	CRK	P46108	DOCK1	Homo sapiens	Q14185	Anti Tag CoIP	33961781
种属内	CRK	P46108	DOCK1	Homo sapiens	Q14185	Peptide Array	17474147
种属内	CRK	P46108	DOCK1	Homo sapiens	Q14185	Anti Tag CoIP	31980649
种属内	CRK	P46108	DOCK1	Homo sapiens	Q14185	Phage Display	35044719
种属内	CRK	P46108	GAB1	Homo sapiens	Q13480	FPS	24728074
种属内	CRK	P46108	CBL	Homo sapiens	P22681	Anti Tag CoIP	31980649
种属内	CRK	P46108	CBL	Homo sapiens	P22681	Anti Bait CoIP	15581361
种属内	CRK	P46108	CBL	Homo sapiens	P22681	Validated Y2H	25814554
种属内	CRK	P46108	CBL	Homo sapiens	P22681	CoIP	8621483
种属内	CRK	P46108	CBL	Homo sapiens	P22681	TAP	19380743
种属内	CRK	P46108	CBL	Homo sapiens	P22681	CoIP	8626543
种属内	CRK	P46108	CBL	Homo sapiens	P22681	Anti Tag CoIP	33961781
种属内	CRK	P46108	BCAR1	Homo sapiens	P56945	Anti Bait CoIP	12799422
种属内	CRK	P46108	BCAR1	Homo sapiens	P56945	Anti Bait CoIP	17038317
种属内	CRK	P46108	BCAR1	Homo sapiens	P56945	Anti Tag CoIP	31980649
种属内	CRK	P46108	PTK2	Homo sapiens	Q05397	Anti Bait CoIP	7561682
种属内	CRK	P46108	PTK2	Homo sapiens	Q05397	Validated Y2H	25814554
种属内	CRK	P46108	PTK2	Homo sapiens	Q05397	Y2H Array	25814554
种属内	CRK	P46108	PTPN4	Homo sapiens	P29074	Y2H	21988832
种属内	CRK	P46108	PTPN4	Homo sapiens	P29074	Confocal	21988832
种属内	CRK	P46108	DPPA4	Homo sapiens	Q7L190	Validated Y2H	26871637
种属内	CRK	P46108	DPPA4	Homo sapiens	Q7L190	Y2H Pooling	16189514
种属内	CRK	P46108	DPPA4	Homo sapiens	Q7L190	Y2H Prey Pooling	26871637
种属内	CRK	P46108	DPPA4	Homo sapiens	Q7L190	Y2H Array	26871637
种属内	CRK	P46108	ERBB3	Homo sapiens	P21860	Protein Array	16273093
种属内	CRK	P46108	USP53	Homo sapiens	Q70EK8	Validated Y2H	27107012
种属内	CRK	P46108	USP53	Homo sapiens	Q70EK8	Validated Y2H	26871637
种属内	CRK	P46108	USP53	Homo sapiens	Q70EK8	Validated Y2H	32296183
种属内	CRK	P46108	USP53	Homo sapiens	Q70EK8	Y2H Array	26871637
种属内	CRK	P46108	USP53	Homo sapiens	Q70EK8	Y2H Prey Pooling	26871637
种属内	CRK	P46108	CBLB	Homo sapiens	Q13191	TAP	19380743
种属内	CRK	P46108	CBLB	Homo sapiens	Q13191	Y2H Array	25814554
种属内	CRK	P46108	CBLB	Homo sapiens	Q13191	Anti Tag CoIP	33961781
种属内	CRK	P46108	PPFIBP2	Homo sapiens	Q8ND30	Y2H Pooling	19447967
种属内	CRK	P46108	PPFIBP2	Homo sapiens	Q8ND30	Y2H Prey Pooling	26871637
种属内	CRK	P46108	PPFIBP2	Homo sapiens	Q8ND30	Validated Y2H	26871637
种属内	CRK	P46108	PPFIBP2	Homo sapiens	Q8ND30	Y2H Array	26871637
种属内	CRK	P46108	PPFIBP2	Homo sapiens	Q8ND30	Anti Tag CoIP	33961781
种属内	CRK	P46108	BUB1	Homo sapiens	O43683	Phage Display	35044719
种属内	CRK	P46108	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
种属内	CRK	P46108	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950
种属内	CRK	P46108	SPEN	Homo sapiens	Q96T58	Phage Display	35044719
种属内	CRK	P46108	WDR83	Homo sapiens	Q9BRX9	Phage Display	35044719
种属内	CRK	P46108	PIK3R3	Homo sapiens	Q92569	Y2H Array	25814554
种属内	CRK	P46108	PIK3R3	Homo sapiens	Q92569	TAP	19380743
种属内	CRK	P46108	PIK3R3	Homo sapiens	Q92569	Validated Y2H	25814554
种属内	CRK	P46108	MAP4K1	Homo sapiens	Q92918	Pull Down	9788432
种属内	CRK	P46108	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
种属内	CRK	P46108	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
种属内	CRK	P46108	ATXN1	Homo sapiens	P54253	Y2H Array	16713569
种属内	CRK	P46108	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
种属内	CRK	P46108	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	26871637
种属内	CRK	P46108	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	26871637
种属内	CRK	P46108	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	26871637
种属内	CRK	P46108	RAPGEF1	Homo sapiens	Q13905	Anti Tag CoIP	33961781
种属内	CRK	P46108	RAPGEF1	Homo sapiens	Q13905	TAP	19380743
种属内	CRK	P46108	RAPGEF1	Homo sapiens	Q13905	Anti Tag CoIP	31980649
种属内	CRK	P46108	RAPGEF1	Homo sapiens	Q13905	CoIP	8621483

种属间: 跨种属相互作用 种属内: 同种属相互作用

CRK 抗体

目录号	产品名	应用	反应物种
HY-P80630	CRK Antibody (YA790)	WB	Human

关联疾病

疾病名称

别名

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome	17p13.3 Duplication Syndrome
17p13.3 Microduplication Syndrome	Trisomy 17p13.3
Chromosome 17p13.3 Centromeric Duplication Syndrome	Dup(17)(P13.3)

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome	Mds
MDLS	Miller Dieker Syndrome
Classical Lissencephaly Syndrome	Lissencephaly Due To 17p13.3 Deletion
Monosomy 17p13.3	Telomeric Deletion 17p
Classical Lissencephaly

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-112622	GSK3186899	Inhibitor	98.61%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-112346	RGB-286147		98.60%	否
HY-RS16222	Crk Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-143322	CRK12-IN-2	Inhibitor	/	否
HY-145812	CRK12-IN-1	Inhibitor	/	否
HY-RS03184	CRK Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CRK	VGNC	VGNC:54290
Felis catus	CRK	VGNC	VGNC:98896
Bos taurus	CRK	VGNC	VGNC:27716
Rattus norvegicus	CRK	RGD	RGD:2405
Macaca mulatta	CRK	VGNC	VGNC:99140
Mus musculus	CRK	MGD	MGI:88508
Others	CRK	NCBI

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