2. Gene
  3. PPFIBP2 - PPFIA binding protein 2 Gene

PPFIBP2 - PPFIA binding protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PPFIA 结合蛋白 2

种属: Homo sapiens

同用名: Cclp1

基因 ID: 8495 | 基因类型: protein coding

关于 PPFIBP2

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:7,513,999-7,667,304 (from NCBI)

This gene has 29 transcripts (splice variants), 292 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 8.3), testis (RPKM 6.8) and 24 other tissues.

功能概要

该基因编码 LAR 蛋白-酪氨酸磷酸酶相互作用蛋白 (liprin) 家族的成员。编码的蛋白质是 β 脂蛋白，通过将 LAR 蛋白酪氨酸磷酸酶募集到质膜，在轴突导向和神经元突触发育中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 2 月]

This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases to the plasma membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

PPFIBP2 基因产物(13)

mRNA Protein Name
NM_001256568.2 NP_001243497.2 liprin-beta-2 isoform 2
NM_001256569.2 NP_001243498.2 liprin-beta-2 isoform 3
NM_001351853.2 NP_001338782.2 liprin-beta-2 isoform 4
NM_001351854.2 NP_001338783.2 liprin-beta-2 isoform 5
NM_001351855.2 NP_001338784.2 liprin-beta-2 isoform 6
NM_001351856.2 NP_001338785.2 liprin-beta-2 isoform 7
NM_001351857.2 NP_001338786.2 liprin-beta-2 isoform 8
NM_001351858.2 NP_001338787.2 liprin-beta-2 isoform 9
NM_001351859.2 NP_001338788.2 liprin-beta-2 isoform 10
NM_001351860.2 NP_001338789.2 liprin-beta-2 isoform 11
NM_001351861.2 NP_001338790.2 liprin-beta-2 isoform 12
NM_001351862.2 NP_001338791.2 liprin-beta-2 isoform 1
NM_003621.5 NP_003612.3 liprin-beta-2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
21462929 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19447967 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPFIBP2 蛋白结构

Integrase_DNA

Integrase_DNA: DNA binding domain of tn916 integrase (192 - 256)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (557 - 618)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (634 - 690)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (715 - 784)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 876 a.a.
蛋白主名 其他名称

liprin-beta-2

PTPRF interacting protein, binding protein 2 (liprin beta 2)

PPFIBP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPFIBP2 Q8ND30 HSF4 Homo sapiens Q9ULV5-2
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Bile Duct Cancer

Bile Duct Carcinoma

Extrahepatic Bile Duct Carcinoma

Carcinoma Of Extrahepatic Bile Duct

Extrahepatic Bile Duct Cancer

Bile Duct Neoplasms

Bile Duct Tumor

Ca Extrahepatic Bile Ducts

Malignant Neoplasm Of The Extrahepatic Bile Duct

Bile Duct Extrahepatic Carcinoma

Malignant Tumor Of Extrahepatic Bile Duct
Bile Duct Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10944 PPFIBP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PPFIBP2 MGD MGI:894649
Felis catus PPFIBP2 VGNC VGNC:68987
Rattus norvegicus PPFIBP2 RGD RGD:1565383
Bos taurus PPFIBP2 VGNC VGNC:58399
Macaca mulatta PPFIBP2 VGNC VGNC:76238
Canis familiaris PPFIBP2 VGNC VGNC:44848
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