2. Gene
  3. IRS4 - insulin receptor substrate 4 Gene

IRS4 - insulin receptor substrate 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胰岛素受体底物 4

种属: Homo sapiens

同用名: CHNG9; IRS-4; PY160

基因 ID: 8471 | 基因类型: protein coding

关于 IRS4

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:108,719,946-108,736,563 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 85 phenotypes. Biased expression in ovary (RPKM 3.0), thyroid (RPKM 1.0) and 3 other tissues.

功能概要

IRS4 编码胰岛素受体底物 4，这是一种细胞质蛋白，包含许多潜在的酪氨酸和丝氨酸/苏氨酸磷酸化位点。已显示酪氨酸磷酸化 IRS4 蛋白与包含 SH2 结构域的细胞质信号分子相关联。 IRS4 蛋白在受体刺激后被胰岛素受体酪氨酸激酶磷酸化。[RefSeq 提供，2008 年 7 月]

IRS4 encodes the Insulin Receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the Insulin Receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]

IRS4 基因产物(2)

mRNA Protein Name
NM_001379150.1 NP_001366079.1 insulin receptor substrate 4 isoform 2
NM_003604.2 NP_003595.1 insulin receptor substrate 4 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11316748 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IRS4 蛋白结构

IRS

IRS: PTB domain (IRS-1 type) (232 - 332)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1257 a.a.
蛋白主名 其他名称

insulin receptor substrate 4

160 kDa phosphotyrosine protein

IRS4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra IRS4 O14654 PTGES3 Homo sapiens Q15185
Lumier
25036637
Intra IRS4 O14654 PTGES3 Homo sapiens Q15185
Anti Tag CoIP
25036637
Intra IRS4 O14654 EGFR Homo sapiens P00533
Protein Array
16273093
Intra IRS4 O14654 YWHAE Homo sapiens P62258
Anti Tag CoIP
25036637
Intra IRS4 O14654 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra IRS4 O14654 CRK Homo sapiens P46108
Pull Down
11316748
Intra IRS4 O14654 CRK Homo sapiens P46108
CoIP
11316748
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypothyroidism, Congenital, Nongoitrous, 9

CHNG9

Congenital Nongoitrous Hypothyroidism 9

Hypothyroidism, Congenital, Non-Goitrous, 9

Hypothyroidism, Congenital, Nongoitrous, Type 9
Hypothyroidism

Thyroid Diseases

Thyroid Disease

Thyroid Deficiency

Thyroid Insufficiency

Dysfunction Thyroid

Thyroid Dysfunction
Hypothyroidism, Central, With Testicular Enlargement

X-Linked Central Congenital Hypothyroidism With Late-Onset Testicular Enlargement

CHTE

Hypothyroidism, Central, And Testicular Enlargement

Igsf1 Deficiency Syndrome

X-Linked Central Congenital Hypothyroidism With Late-Onset Macroorchidism

Central Hypothyroidism And Testicular Enlargement

Hypothyroidism, Central, Testicular Enlargement
Boutonneuse Fever

Mediterranean Spotted Fever

African Tick Typhus

Boutonneuse Disease

Conor And Bruch'S Disease

Kenya Fever

Kenya Tick Typhus

Kenyan Tick Typhus

Marseilles Fever

Mediterranean Tick Fever

Rickettsia Conorii Spotted Fever

South African Tick-Bite Fever

African Tick Bite Fever
Breast Rhabdomyosarcoma

Rhabdomyosarcoma Of The Breast
Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome

PWS

Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome

Upd(15)Mat
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06919 IRS4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus IRS4 MGD MGI:1338009
Bos taurus IRS4 VGNC VGNC:30285
Macaca mulatta IRS4 VGNC VGNC:73767
Felis catus IRS4 VGNC VGNC:67831
Rattus norvegicus IRS4 RGD RGD:1562442
Canis familiaris IRS4 VGNC VGNC:42100
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