RAPGEF1 - Rap guanine nucleotide exchange factor 1 Gene

中文名称：Rap 鸟嘌呤核苷酸交换因子 1

种属: Homo sapiens

同用名: C3G; GRF2

基因 ID: 2889 | 基因类型: protein coding

关于 RAPGEF1

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:131,576,775-131,740,076 (from NCBI)

This gene has 8 transcripts (splice variants), 252 orthologues and 24 paralogues. Ubiquitous expression in placenta (RPKM 13.7), lymph node (RPKM 12.3) and 25 other tissues.

功能概要

该基因编码人鸟嘌呤核苷酸交换因子。它通过结合 CRK 的 SH3 结构域并激活 GTP 酶 Ras 家族的几个成员来转导来自 CRK 的信号。这种信号级联可能参与细胞凋亡、整合素介导的信号转导和细胞转化。已经描述了该基因的几种可变剪接的转录本变体，但尚未确定某些变体的全长性质。[RefSeq 提供，2008 年 7 月]

This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in Apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

RAPGEF1 基因产物(7)

mRNA	Protein	Name
NM_001304275.2	NP_001291204.1	rap guanine nucleotide exchange factor 1 isoform c
NM_001377935.1	NP_001364864.1	rap guanine nucleotide exchange factor 1 isoform d
NM_001377936.1	NP_001364865.1	rap guanine nucleotide exchange factor 1 isoform e
NM_001377937.1	NP_001364866.1	rap guanine nucleotide exchange factor 1 isoform f
NM_001377938.1	NP_001364867.1	rap guanine nucleotide exchange factor 1 isoform g
NM_005312.4	NP_005303.2	rap guanine nucleotide exchange factor 1 isoform a
NM_198679.2	NP_941372.1	rap guanine nucleotide exchange factor 1 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables guanyl-nucleotide exchange factor activity	IDA IDA: 通过直接分析推断	10548487	GOA
enables guanyl-nucleotide exchange factor activity	IMP IMP: 通过突变表型推断	21840392	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9748234	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Rap protein signal transduction	IMP IMP: 通过突变表型推断	21840392	GOA
involved in cellular response to cAMP	IDA IDA: 通过直接分析推断	21840392	GOA
involved in cellular response to nerve growth factor stimulus	IDA IDA: 通过直接分析推断	17724123	GOA
involved in establishment of endothelial barrier	IMP IMP: 通过突变表型推断	21840392	GOA
involved in nerve growth factor signaling pathway	IDA IDA: 通过直接分析推断	17724123	GOA
involved in positive regulation of GTPase activity	IDA IDA: 通过直接分析推断	10548487	GOA
involved in positive regulation of GTPase activity	IMP IMP: 通过突变表型推断	21840392	GOA
involved in positive regulation of neuron projection development	IMP IMP: 通过突变表型推断	17724123	GOA
involved in regulation of cell junction assembly	IMP IMP: 通过突变表型推断	21840392	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	17515907	GOA
located in early endosome	IDA IDA: 通过直接分析推断	17724123	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAPGEF1 蛋白结构

RasGEF_N

RasGEF

0
200
400
600
800
1000
1077 a.a.

蛋白主名

其他名称

rap guanine nucleotide exchange factor 1

CRK SH3-binding GNRP

RAPGEF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RAPGEF1	Q13905	CRK	Homo sapiens	P46108-1	Anti Bait CoIP	19001122
种属内	RAPGEF1	Q13905	ABL1	Homo sapiens	P00519	Anti Bait CoIP	16443220
种属内	RAPGEF1	Q13905	ABL1	Homo sapiens	P00519	Pull Down	16443220
种属内	RAPGEF1	Q13905	ABL1	Homo sapiens	P00519	Peptide Array	17474147
种属内	RAPGEF1	Q13905	NCK1	Homo sapiens	P16333	Peptide Array	17474147
种属内	RAPGEF1	Q13905	FYN	Homo sapiens	P06241	Peptide Array	17474147
种属内	RAPGEF1	Q13905	PIK3R1	Homo sapiens	P27986	Peptide Array	17474147
种属内	RAPGEF1	Q13905	CRK	Homo sapiens	P46108	Peptide Array	17474147
种属内	RAPGEF1	Q13905	CRKL	Homo sapiens	P46109	Anti Tag CoIP	33961781
种属内	RAPGEF1	Q13905	CRKL	Homo sapiens	P46109	Anti Bait CoIP	16443220

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Nephrotic Syndrome, Type 7

Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 7
NPHS7	Nephrotic Syndrome Type 7
Ig-Mediated Membranoproliferative Glomerulonephritis	Ig-Mediated Mpgn
Immunoglobulin-Mediated Mpgn	Nephrotic Syndrome, Type 7, With Membranoproliferative Glomerulonephritis
Hemolytic Uremic Syndrome, Atypical 7	Nephrotic Syndrome Type 7 With Membranoptoliferative Glomerulonephritis
Hemolytic Uremic Syndrome With Dgke Deficiency	Hus With Dgke Deficiency
Hemolytic Uremic Syndrome Atypical 7	AHUS7
Nephrotic Syndrome 7	Nephrotic Syndrome Type 7 With Membranoproliferative Glomerulonephritis

Exudative Glomerulonephritis

Transient Refractive Change

Membranoproliferative Glomerulonephritis

Mesangiocapillary Glomerulonephritis	Dense Deposit Disease
Membranoproliferative Glomerulonephritis Type 2	Primary Membranoproliferative Glomerulonephritis
Mesangiocapillary Glomerulonephritis, Type Ii	Glomerulonephritis, Membranoproliferative
Chronic Glomerulonephritis, Lobular	Lobular Glomerulonephritis
Ddd	Glomerulonephritis Membranoproliferative Type 2
Mpgn 2	Membranoproliferative Glomerulonephritis Type Ii
Mesangiocapillary Glomerulonephritis Type 2	Mpgn
Primary Mpgn	Glomerulonephritis Membranoproliferative
Membranoproliferative Glomerulonephritis, Type Ii

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Complement Deficiency

Complement Deficiency Disease

Hereditary Complement Deficiency Diseases

Proliferative Glomerulonephritis

Crescentic Glomerulonephritis

Idiopathic Crescentic Glomerulonephritis

Acute Proliferative Glomerulonephritis

Acute Glomerulonephritis With Lesion Of Proliferative Glomerulonephritis

Acute Post-Streptococcal Glomerulonephritis

Macular Degeneration, Age-Related, 1

Macular Degeneration	Age-Related Macular Degeneration
Macular Degeneration, Age-Related	Age Related Macular Degeneration
Age Related Macular Degeneration 1	ARMD1
Senile Macular Degeneration	Maculopathy, Age-Related, 1
Macular Degeneration, Age-Related, Reduced Risk Of	Age Related Maculopathy 1
Age Related Maculopathies	Age Related Maculopathy
Senile Macular Retinal Degeneration	Macular Degeneration Of Retina
Age-Related Maculopathy	Amd
Armd	Age-Related Maculopathy, Susceptibility To
Maculopathy Age-Related	Macular Degeneration, Age-Related, 1, Susceptibility To
Maculopathy, Age-Related	Macular Degeneration, Age-Related, Type 1
Macular Degeneration, Age-Related, 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11660	RAPGEF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RAPGEF1	RGD	RGD:619793
Bos taurus	RAPGEF1	VGNC	VGNC:33722
Canis familiaris	RAPGEF1	VGNC	VGNC:45346
Mus musculus	RAPGEF1	MGD	MGI:104580
Felis catus	RAPGEF1	VGNC	VGNC:67459
Macaca mulatta	RAPGEF1	VGNC	VGNC:76582

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RAPGEF1 - Rap guanine nucleotide exchange factor 1 Gene

关于 RAPGEF1

功能概要

RAPGEF1 基因产物(7)

RAPGEF1 蛋白结构

RAPGEF1 蛋白互作信息

关联疾病

直系同源

热门区域

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RAPGEF1 - Rap guanine nucleotide exchange factor 1 Gene

关于 RAPGEF1

功能概要

RAPGEF1 基因产物(7)

RAPGEF1 蛋白结构

RAPGEF1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z