1. Gene
  2. CRKL - CRK like proto-oncogene, adaptor protein Gene

CRKL - CRK like proto-oncogene, adaptor protein Gene

中文名称:CRK 样原癌基因、衔接蛋白

种属: Homo sapiens

基因 ID: 1399 | 基因类型: protein coding

关于 CRKL

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,917,407-20,953,747 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 22.4), bone marrow (RPKM 22.0) and 25 other tissues.

功能概要

该基因编码含有 SH2 和 SH3 (Src 同源) 结构域的蛋白激酶,已显示可激活 Ras 和 JUN 激酶信号通路并以 Ras 依赖性方式转化成纤维细胞。它是 Bcr-Abl 酪氨酸激酶的底物,在 Bcr-Abl 的成纤维细胞转化中发挥作用,并且可能具有致癌性。[RefSeq 提供,2009 年 1 月]

This gene encodes a protein kinase containing SH2 and SH3 (Src homology) domains which has been shown to activate the Ras and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the Bcr-Abl tyrosine kinase, plays a role in fibroblast transformation by Bcr-Abl, and may be oncogenic.[provided by RefSeq, Jan 2009]

CRKL 基因产物(1)

mRNA Protein Name
NM_005207.4 NP_005198.1 crk-like protein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
IDA: 通过直接分析推断
29581031 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17161365 GOA
enables phosphotyrosine residue binding IPI
IPI: 通过物理相互作用推断
20624904 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8626543 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CRKL 蛋白结构

SH2

SH2: SH2 domain (14 - 88)

SH3_1

SH3_1: SH3 domain (130 - 175)

SH3_2

SH3_2: Variant SH3 domain (240 - 293)

  • 0
  • 100
  • 200
  • 303 a.a.
蛋白主名 其他名称

crk-like protein

v-crk avian sarcoma virus CT10 oncogene homolog-like

CRKL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CRKL P46109 FLT1 Homo sapiens P17948
Anti Tag CoIP
23397142
种属内
CRKL P46109 FLT1 Homo sapiens P17948
PLA
23397142
种属间
CRKL P46109 Kcnma1 Mus musculus Q08460
Anti Bait CoIP
17065230
种属内
CRKL P46109 BLK Homo sapiens P51451
Validated Y2H
32296183
种属内
CRKL P46109 PDGFRA Homo sapiens P16234
CoIP
9546424
种属内
CRKL P46109 PDGFRA Homo sapiens P16234
PLA
25241761
种属内
CRKL P46109 PDGFRA Homo sapiens P16234
Enzymatic Study
9546424
种属内
CRKL P46109 EGFR Homo sapiens P00533
Ub Reconstruction
24658140
种属内
CRKL P46109 PSMC6 Homo sapiens P62333
Validated Y2H
32296183
种属内
CRKL P46109 ABL1 Homo sapiens P00519
Anti Tag CoIP
33961781
种属内
CRKL P46109 ABL1 Homo sapiens P00519
Anti Bait CoIP
16443220
种属内
CRKL P46109 ABL1 Homo sapiens P00519
Pull Down
16443220
种属内
CRKL P46109 GAB1 Homo sapiens Q13480
PLA
25241761
种属内
CRKL P46109 GAB1 Homo sapiens Q13480
FPS
24728074
种属内
CRKL P46109 GAB1 Homo sapiens Q13480
PLA
23397142
种属内
CRKL P46109 CBL Homo sapiens P22681
Anti Tag CoIP
33961781
种属内
CRKL P46109 CBL Homo sapiens P22681
CoIP
8662998
种属内
CRKL P46109 CBL Homo sapiens P22681
Y2H Array
25814554
种属内
CRKL P46109 CBL Homo sapiens P22681
Anti Bait CoIP
16982329
种属内
CRKL P46109 ITGB1 Homo sapiens P05556
Anti Bait CoIP
19168626
种属内
CRKL P46109 USP53 Homo sapiens Q70EK8
Validated Y2H
32296183
种属内
CRKL P46109 CBLB Homo sapiens Q13191
CoIP
10022120
种属内
CRKL P46109 CBLB Homo sapiens Q13191
Validated Y2H
25814554
种属内
CRKL P46109 DCBLD2 Homo sapiens Q96PD2
Pull Down
23770091
种属内
CRKL P46109 MAP4K1 Homo sapiens Q92918
Pull Down
9788432
种属内
CRKL P46109 MAP4K1 Homo sapiens Q92918
CoIP
9788432
种属内
CRKL P46109 CRKL Homo sapiens P46109
X-Ray Diffraction
17161365
种属内
CRKL P46109 CRKL Homo sapiens P46109
Comigration in SDS
17161365
种属内
CRKL P46109 RAPGEF1 Homo sapiens Q13905
Anti Tag CoIP
26496610
种属内
CRKL P46109 RAPGEF1 Homo sapiens Q13905
Pull Down
16443220
种属间
CRKL P46109 Kidins220 Rattus norvegicus Q9EQG6
Pull Down
16284401
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome

Autosomal Dominant Opitz G/Bbb Syndrome

Catch22

Cayler Cardiofacial Syndrome

Conotruncal Anomaly Face Syndrome

Digeorge Syndrome

Sedlackova Syndrome

Shprintzen Syndrome

Velocardiofacial Syndrome

22q11.2 Distal Deletion Syndrome

Distal 22q11.2 Microdeletion Syndrome

22q11.2ds

Vcfs

Velo-Cardio-Facial Syndrome

Distal Chromosome 22q11.2 Deletion Syndrome

Chromosome 22q11.2 Deletion Syndrome Distal

Chromosome 22q11.2 Deletion Syndrome

Deletion 22q11.2 Syndrome

22q11ds

Catch 22

Digeorge Sequence

Microdeletion 22q11.2

Monosomy 22q11

Takao Syndrome

Distal Del(22)(Q11.2)

Distal Monosomy 22q11.2

Catch 22 Syndrome

Chromosome Deletion Syndrome 22q11.2, Distal

Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome

DGS

Hypoplasia Of Thymus And Parathyroids

Third And Fourth Pharyngeal Pouch Syndrome

22q11.2 Deletion Syndrome

Digeorge Sequence

Digeorge'S Syndrome

Pharyngeal Pouch Syndrome

Di-George Syndrome

Shprintzen Syndrome

T-Cell Immunodeficiency With Thymic Aplasia

Nezelof Syndrome

T-Lymphocyte Deficiency

TIDTA

Immune Defect Due To Absence Of Thymus

Thymic Aplasia

Nezelof'S Syndrome

Thymic Dysplasia With Normal Immunoglobulins

Thymic Aplasia Syndrome

T-Lymphocyte Immunodeficiency

Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex

Exstrophy-Epispadias Complex

Bladder Exstrophy-Epispadias-Cloacal Extrophy Complex

Beec

Eec

Exstrophy Of The Bladder

Bladder Exstrophy

Bladder Exstrophy And Epispadias Complex

Velocardiofacial Syndrome

Shprintzen Syndrome

VCFS

Chromosome 22q11.2 Deletion Syndrome

Vcf Syndrome

Shprintzen Vcf Syndrome

Vcf-Velocardiofacial Syndrome

Velo-Cardio-Facial Syndrome

Digeorge Syndrome

22q11 Deletion Syndrome

Conotruncal Anomaly Face Syndrome

Chromosome 22q11.2 Duplication Syndrome

Chromosome 22q11.2 Microduplication Syndrome

22q11.2 Microduplication Syndrome

22q11.2 Duplication Syndrome

Duplication 22q11.2

Trisomy 22q11.2

22q11.2 Duplication

Dup(22)(Q11)

Chromosomal Deletion Syndrome
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect

Taussig-Bing Syndrome

Dextrotransposition Of Aorta

Taussig-Bing Syndrome Or Defect

Dorv

Dorv With Subpulmonary Vsd

Dorv-Tga

Double Outlet Right Ventricle With Transposition Of The Great Arteries

Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type

Taussig-Bing Heart

Taussig-Bing Malformation

Taussig-Bing Complex

Taussig-Bing Defect

Taussig-Bing

Double Outlet Right Ventricle With Remote Ventricular Septal Defect

Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect

Double Outlet Right Ventricle With Non-Committed Interventricular Communication

Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis

Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome

Deletion 1p36

Monosomy 1p36

Subtelomeric 1p36 Deletion

Monosomy 1p36 Syndrome

Distal Monosomy 1p36

Del(1)(P36)

Deletion 1pter

Monosomy 1pter

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus CRKL VGNC VGNC:53897
Mus musculus CRKL MGD MGI:104686
Rattus norvegicus CRKL RGD RGD:1308531
Felis catus CRKL VGNC VGNC:61182
Canis familiaris CRKL VGNC VGNC:39619
Others CRKL NCBI