CBLB - Cbl proto-oncogene B Gene

中文名称：Cbl 原癌基因 B

种属: Homo sapiens

同用名: Cbl-b; RNF56; Nbla00127

关于 CBLB

功能概要

该基因编码一种 E3 泛素蛋白连接酶，该连接酶通过将泛素从 E2 泛素结合酶转移到底物来促进蛋白体介导的蛋白质降解。编码的蛋白质通过限制 T 细胞受体、B 细胞受体和高亲和力免疫球蛋白 epsilon 受体激活来参与免疫反应的调节。对小鼠的研究表明，该基因参与抗真菌宿主防御，其抑制会导致真菌杀灭增加。操纵该基因可能有利于针对多种病症实施免疫疗法，包括癌症、自身免疫性疾病、过敏和感染。[RefSeq 提供，2017 年 9 月]

This gene encodes an E3 ubiquitin-protein Ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating Enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in Antifungal host defense and that its inhibition leads to increased Fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including Cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]