GLRX3 - glutaredoxin 3 Gene

中文名称：谷氧还蛋白 3

种属: Homo sapiens

同用名: GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3

基因 ID: 10539 | 基因类型: protein coding

关于 GLRX3

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:130,136,391-130,180,377 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.3), lymph node (RPKM 8.3) and 25 other tissues.

功能概要

该基因编码谷氧还蛋白家族的一个成员。谷氧还蛋白是使用谷胱甘肽作为辅助因子来还原多种底物的氧化还原酶。编码的蛋白质结合并调节蛋白激酶 C theta 的功能。编码的蛋白质也可能抑制细胞凋亡并在细胞生长中发挥作用，该基因的表达可能是癌症的标志。该基因的假基因位于 6 号和 9 号染色体的短臂上。已观察到该基因的选择性剪接转录变体。[RefSeq 提供，2010 年 12 月]

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase Enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit Apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for Cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

GLRX3 基因产物(3)

mRNA	Protein	Name
NM_001199868.2	NP_001186797.1	glutaredoxin-3 isoform 1
NM_001321980.2	NP_001308909.1	glutaredoxin-3 isoform 2
NM_006541.5	NP_006532.2	glutaredoxin-3 isoform 1

GLRX3 蛋白结构

Thioredoxin

Glutaredoxin

0
100
200
300
335 a.a.

蛋白主名

其他名称

glutaredoxin-3

PKC-interacting cousin of thioredoxin

关联疾病

疾病名称

别名

X-Linked Intellectual Disability-Short Stature-Overweight Syndrome

Mrx12	Mrx35
X-Linked Mental Retardation 12	X-Linked Mental Retardation 35

Transvestism

Dual-Role Transvestism	Fetishistic Transvestism
Cross Dresser	Transvestic Fetishism

Friedreich Ataxia

Friedreich Ataxia 1	FRDA
Friedreich Ataxia With Retained Reflexes	Frda1
Fa	Friedreich'S Ataxia
Hereditary Spinal Ataxia	Fa1
Friedreich'S Tabes	Hereditary Spinal Sclerosis
Spinocerebellar Ataxia, Friedreich	Friedreich Spinocerebellar Ataxia
Friedrich'S Ataxia

Transposition Of The Great Arteries, Dextro-Looped

Transposition Of The Great Arteries	DTGA1
Dextro-Looped Transposition Of The Great Arteries	DTGA
Congenitally Uncorrected Transposition Of The Great Arteries	Congenitally Uncorrected Transposition Of The Great Vessels
D-Tga	Isolated Ventriculoarterial Discordance
Ventriculoarterial Discordance With Atrioventricular Concordance	Dextro-Transposition Of The Great Arteries
Transposition Of The Great Vessels	Great Vessels Transposition
Transposition Of The Great Arteries, Dextro-Looped 1	Arteries, Great, Transposition, Dextro-Looped
Ventriculoarterial Discordance, Isolated	D-Transposition Of The Great Arteries
Complete Transposition	Tga
Tgv	Transposition Of Great Vessels
Transposition Of The Great Arteries Dextro-Looped 1	Dextro-Looped Transposition Of The Great Arteries 1
Discordant Ventriculoarterial Connection	Complete Transposition Of Great Vessels
Great Vessels Complete Transposition	Total Great Vessel Transposition
Transposition Of Great Arteries	Complete Tga - [Transposition Of The Great Arteries]
Tga - [Transposition Of Great Arteries]	Tgv - [Transposition Of Great Vessels]
Transposition Of Great Vessels Nos	Transposed Vessels Nos

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05498	GLRX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	GLRX3	MGD	MGI:1353653
Macaca mulatta	GLRX3	VGNC	VGNC:103820
Rattus norvegicus	GLRX3	RGD	RGD:69414
Canis familiaris	GLRX3	VGNC	VGNC:41275
Bos taurus	GLRX3	VGNC	VGNC:29417

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GLRX3 - glutaredoxin 3 Gene

关于 GLRX3

功能概要

GLRX3 基因产物(3)

GLRX3 蛋白结构

关联疾病

直系同源

热门区域

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GLRX3 - glutaredoxin 3 Gene

关于 GLRX3

功能概要

GLRX3 基因产物(3)

GLRX3 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z