2. Gene
  3. GLRX3 - glutaredoxin 3 Gene

GLRX3 - glutaredoxin 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：谷氧还蛋白 3

种属: Homo sapiens

同用名: GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3

基因 ID: 10539 | 基因类型: protein coding

关于 GLRX3

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:130,136,391-130,180,377 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.3), lymph node (RPKM 8.3) and 25 other tissues.

功能概要

该基因编码谷氧还蛋白家族的一个成员。谷氧还蛋白是使用谷胱甘肽作为辅助因子来还原多种底物的氧化还原酶。编码的蛋白质结合并调节蛋白激酶 C theta 的功能。编码的蛋白质也可能抑制细胞凋亡并在细胞生长中发挥作用，该基因的表达可能是癌症的标志。该基因的假基因位于 6 号和 9 号染色体的短臂上。已观察到该基因的选择性剪接转录变体。[RefSeq 提供，2010 年 12 月]

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase Enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit Apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for Cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

GLRX3 基因产物(3)

mRNA Protein Name
NM_001199868.2 NP_001186797.1 glutaredoxin-3 isoform 1
NM_001321980.2 NP_001308909.1 glutaredoxin-3 isoform 2
NM_006541.5 NP_006532.2 glutaredoxin-3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10636891 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in [2Fe-2S] cluster assembly IDA
IDA: 通过直接分析推断
27519415 GOA
involved in cell redox homeostasis IDA
IDA: 通过直接分析推断
27519415 GOA
involved in intracellular iron ion homeostasis IDA
IDA: 通过直接分析推断
27519415 GOA
involved in iron-sulfur cluster assembly IDA
IDA: 通过直接分析推断
27519415 GOA
involved in protein maturation by iron-sulfur cluster transfer IDA
IDA: 通过直接分析推断
27519415 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of iron-sulfur cluster assembly complex IPI
IPI: 通过物理相互作用推断
22309771 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GLRX3 蛋白结构

Thioredoxin

Thioredoxin: Thioredoxin (21 - 114)

Glutaredoxin

Glutaredoxin: Glutaredoxin (147 - 210)

Glutaredoxin

Glutaredoxin: Glutaredoxin (248 - 312)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
蛋白主名 其他名称

glutaredoxin-3

PKC-interacting cousin of thioredoxin

关联疾病

疾病名称 别名
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome

Mrx12

Mrx35

X-Linked Mental Retardation 12

X-Linked Mental Retardation 35
Transvestism

Dual-Role Transvestism

Fetishistic Transvestism

Cross Dresser

Transvestic Fetishism
Friedreich Ataxia

Friedreich Ataxia 1

FRDA

Friedreich Ataxia With Retained Reflexes

Frda1

Fa

Friedreich'S Ataxia

Hereditary Spinal Ataxia

Fa1

Friedreich'S Tabes

Hereditary Spinal Sclerosis

Spinocerebellar Ataxia, Friedreich

Friedreich Spinocerebellar Ataxia

Friedrich'S Ataxia
Transposition Of The Great Arteries, Dextro-Looped

Transposition Of The Great Arteries

DTGA1

Dextro-Looped Transposition Of The Great Arteries

DTGA

Congenitally Uncorrected Transposition Of The Great Arteries

Congenitally Uncorrected Transposition Of The Great Vessels

D-Tga

Isolated Ventriculoarterial Discordance

Ventriculoarterial Discordance With Atrioventricular Concordance

Dextro-Transposition Of The Great Arteries

Transposition Of The Great Vessels

Great Vessels Transposition

Transposition Of The Great Arteries, Dextro-Looped 1

Arteries, Great, Transposition, Dextro-Looped

Ventriculoarterial Discordance, Isolated

D-Transposition Of The Great Arteries

Complete Transposition

Tga

Tgv

Transposition Of Great Vessels

Transposition Of The Great Arteries Dextro-Looped 1

Dextro-Looped Transposition Of The Great Arteries 1

Discordant Ventriculoarterial Connection

Complete Transposition Of Great Vessels

Great Vessels Complete Transposition

Total Great Vessel Transposition

Transposition Of Great Arteries

Complete Tga - [Transposition Of The Great Arteries]

Tga - [Transposition Of Great Arteries]

Tgv - [Transposition Of Great Vessels]

Transposition Of Great Vessels Nos

Transposed Vessels Nos
Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05498 GLRX3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GLRX3 MGD MGI:1353653
Macaca mulatta GLRX3 VGNC VGNC:103820
Rattus norvegicus GLRX3 RGD RGD:69414
Canis familiaris GLRX3 VGNC VGNC:41275
Bos taurus GLRX3 VGNC VGNC:29417
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