2. Gene
  3. GLRX3 - glutaredoxin 3 Gene

GLRX3 - glutaredoxin 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：谷氧还蛋白 3

种属: Homo sapiens

同用名: GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3

基因 ID: 10539 | 基因类型: protein coding

关于 GLRX3

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:130,136,391-130,180,377 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.3), lymph node (RPKM 8.3) and 25 other tissues.

功能概要

该基因编码谷氧还蛋白家族的一个成员。谷氧还蛋白是使用谷胱甘肽作为辅助因子来还原多种底物的氧化还原酶。编码的蛋白质结合并调节蛋白激酶 C theta 的功能。编码的蛋白质也可能抑制细胞凋亡并在细胞生长中发挥作用，该基因的表达可能是癌症的标志。该基因的假基因位于 6 号和 9 号染色体的短臂上。已观察到该基因的选择性剪接转录变体。[RefSeq 提供，2010 年 12 月]

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase Enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit Apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for Cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

GLRX3 基因产物(3)

mRNA Protein Name
NM_001199868.2 NP_001186797.1 glutaredoxin-3 isoform 1
NM_001321980.2 NP_001308909.1 glutaredoxin-3 isoform 2
NM_006541.5 NP_006532.2 glutaredoxin-3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10636891 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in [2Fe-2S] cluster assembly IDA
IDA: 通过直接分析推断
27519415 GOA
involved in cell redox homeostasis IDA
IDA: 通过直接分析推断
27519415 GOA
involved in intracellular iron ion homeostasis IDA
IDA: 通过直接分析推断
27519415 GOA
involved in iron-sulfur cluster assembly IDA
IDA: 通过直接分析推断
27519415 GOA
involved in protein maturation by iron-sulfur cluster transfer IDA
IDA: 通过直接分析推断
27519415 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of iron-sulfur cluster assembly complex IPI
IPI: 通过物理相互作用推断
22309771 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GLRX3 蛋白结构

Thioredoxin

Thioredoxin: Thioredoxin (21 - 114)

Glutaredoxin

Glutaredoxin: Glutaredoxin (147 - 210)

Glutaredoxin

Glutaredoxin: Glutaredoxin (248 - 312)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
蛋白主名 其他名称

glutaredoxin-3

PKC-interacting cousin of thioredoxin

GLRX3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GLRX3 O76003 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
种属内
GLRX3 O76003 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 KRTAP10-9 Homo sapiens P60411
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP10-5 Homo sapiens P60370
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 KRTAP10-5 Homo sapiens P60370
Validated Y2H
25416956
种属内
GLRX3 O76003 KRTAP10-5 Homo sapiens P60370
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
25416956
种属内
GLRX3 O76003 KRTAP10-11 Homo sapiens P60412
MAPPIT
25416956
种属内
GLRX3 O76003 KRTAP10-11 Homo sapiens P60412
Validated Y2H
25416956
种属内
GLRX3 O76003 KRTAP10-11 Homo sapiens P60412
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 ADAMTSL3 Homo sapiens P82987
Validated Y2H
32296183
种属内
GLRX3 O76003 LCE2D Homo sapiens Q5TA82
Validated Y2H
32296183
种属内
GLRX3 O76003 LCE2D Homo sapiens Q5TA82
Validated Y2H
25416956
种属内
GLRX3 O76003 KRTAP5-6 Homo sapiens Q6L8G9
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
25416956
种属内
GLRX3 O76003 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
32296183
种属内
GLRX3 O76003 ZNF774 Homo sapiens Q6NX45
Validated Y2H
32296183
种属内
GLRX3 O76003 RECK Homo sapiens Q6P9E2
Validated Y2H
32296183
种属内
GLRX3 O76003 TMEM25 Homo sapiens Q86YD3
Validated Y2H
25416956
种属内
GLRX3 O76003 OLFM3 Homo sapiens Q96PB7
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 OLFM3 Homo sapiens Q96PB7
Validated Y2H
25416956
种属内
GLRX3 O76003 KRTAP4-11 Homo sapiens Q9BYQ6
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Array
25416956
种属内
GLRX3 O76003 KRTAP4-7 Homo sapiens Q9BYR0
Validated Y2H
25416956
种属内
GLRX3 O76003 KRTAP4-7 Homo sapiens Q9BYR0
Y2H Array
25416956
种属内
GLRX3 O76003 KRTAP4-7 Homo sapiens Q9BYR0
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 IL10 Homo sapiens P22301
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
25416956
种属内
GLRX3 O76003 KRT38 Homo sapiens O76015
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 KRT38 Homo sapiens O76015
Validated Y2H
25416956
种属内
GLRX3 O76003 BOLA1 Homo sapiens Q9Y3E2
Anti Tag CoIP
33961781
种属内
GLRX3 O76003 BOLA1 Homo sapiens Q9Y3E2
Anti Tag CoIP
28514442
种属内
GLRX3 O76003 BOLA1 Homo sapiens Q9Y3E2
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 BOLA1 Homo sapiens Q9Y3E2
Validated Y2H
32296183
种属内
GLRX3 O76003 BOLA1 Homo sapiens Q9Y3E2
Y2H Array
25416956
种属内
GLRX3 O76003 METAP1 Homo sapiens P53582
Validated Y2H
32296183
种属内
GLRX3 O76003 RGS20 Homo sapiens O76081
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
种属内
GLRX3 O76003 ZNF490 Homo sapiens Q9ULM2
Validated Y2H
32296183
种属内
GLRX3 O76003 GNG13 Homo sapiens Q9P2W3
Validated Y2H
32296183
种属内
GLRX3 O76003 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP12-3 Homo sapiens P60328
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP4-4 Homo sapiens Q9BYR3
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP5-4 Homo sapiens Q6L8H1
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP5-3 Homo sapiens Q6L8H2
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP5-3 Homo sapiens Q6L8H2
Y2H Array
32296183
种属内
GLRX3 O76003 CDC20B Homo sapiens Q86Y33-5
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP4-5 Homo sapiens Q9BYR2
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP5-11 Homo sapiens Q6L8G4
Validated Y2H
32296183
种属内
GLRX3 O76003 BOLA3 Homo sapiens Q53S33
Validated Y2H
32296183
种属内
GLRX3 O76003 IRX6 Homo sapiens P78412
Validated Y2H
32296183
种属内
GLRX3 O76003 STRA6 Homo sapiens Q9BX79-6
Validated Y2H
32296183
种属内
GLRX3 O76003 KLHDC9 Homo sapiens Q8NEP7
Validated Y2H
32296183
种属内
GLRX3 O76003 CA9 Homo sapiens Q16790
Validated Y2H
32296183
种属内
GLRX3 O76003 CERCAM Homo sapiens Q5T4B2
Validated Y2H
32296183
种属内
GLRX3 O76003 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
种属内
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81-1
NMR
26302480
种属内
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81-1
GMS
26302480
种属内
GLRX3 O76003 BOLA2 Homo sapiens Q9H3K6
Anti Tag CoIP
33961781
种属内
GLRX3 O76003 BOLA2 Homo sapiens Q9H3K6
Anti Tag CoIP
27519415
种属内
GLRX3 O76003 HEPH Homo sapiens Q9BQS7-3
Validated Y2H
32296183
种属内
GLRX3 O76003 TRIM36 Homo sapiens Q9NQ86
Validated Y2H
32296183
种属内
GLRX3 O76003 TRIM36 Homo sapiens Q9NQ86
Y2H Array
25416956
种属内
GLRX3 O76003 TRIM36 Homo sapiens Q9NQ86
Validated Y2H
25416956
种属内
GLRX3 O76003 ZNF124 Homo sapiens Q15973
Validated Y2H
32296183
种属内
GLRX3 O76003 ZNF148 Homo sapiens Q9UQR1
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 SMARCC1 Homo sapiens Q92922
Validated Y2H
32296183
种属内
GLRX3 O76003 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 PFDN5 Homo sapiens Q99471
Y2H Array
25416956
种属内
GLRX3 O76003 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
种属内
GLRX3 O76003 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 TRAF1 Homo sapiens Q13077
BFG-2H
27107012
种属内
GLRX3 O76003 TRAF1 Homo sapiens Q13077
Validated Y2H
27107012
种属内
GLRX3 O76003 PRKCQ Homo sapiens Q04759
Y2H
10636891
种属内
GLRX3 O76003 PRKCQ Homo sapiens Q04759
Pull Down
10636891
种属内
GLRX3 O76003 PRKCQ Homo sapiens Q04759
Imaging
10636891
种属内
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Validated Y2H
25416956
种属内
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Validated Y2H
32296183
种属内
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Y2H Array
25416956
种属内
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Y2H Pooling
16189514
种属内
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Anti Tag CoIP
33961781
种属内
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Y2H
21516116
种属内
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Y2H Array
31515488
种属内
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 CIAPIN1 Homo sapiens Q6FI81
BiFC
25416956
种属内
GLRX3 O76003 NTF4 Homo sapiens P34130
Validated Y2H
32296183
种属内
GLRX3 O76003 HSD3B7 Homo sapiens Q9H2F3
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
种属内
GLRX3 O76003 KRTAP5-9 Homo sapiens P26371
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
种属内
GLRX3 O76003 TRIM42 Homo sapiens Q8IWZ5
Validated Y2H
25416956
种属内
GLRX3 O76003 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
25416956
种属内
GLRX3 O76003 MOXD1 Homo sapiens Q6UVY6
Validated Y2H
32296183
种属内
GLRX3 O76003 MOXD1 Homo sapiens Q6UVY6
Validated Y2H
25416956
种属内
GLRX3 O76003 MOXD1 Homo sapiens Q6UVY6
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 MOXD1 Homo sapiens Q6UVY6
Y2H Array
25416956
种属内
GLRX3 O76003 CGGBP1 Homo sapiens Q9UFW8
Y2H Array
25416956
种属内
GLRX3 O76003 CGGBP1 Homo sapiens Q9UFW8
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 CGGBP1 Homo sapiens Q9UFW8
Validated Y2H
25416956
种属内
GLRX3 O76003 SOX7 Homo sapiens Q9BT81
Validated Y2H
25416956
种属内
GLRX3 O76003 SOX7 Homo sapiens Q9BT81
Y2H Array
25416956
种属内
GLRX3 O76003 TCL1B Homo sapiens O95988
Validated Y2H
32296183
种属内
GLRX3 O76003 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Pooling
16189514
种属内
GLRX3 O76003 KRTAP4-12 Homo sapiens Q9BQ66
Validated Y2H
32296183
种属内
GLRX3 O76003 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Array
25416956
种属内
GLRX3 O76003 PLSCR1 Homo sapiens O15162
Y2H Array
25416956
种属内
GLRX3 O76003 ZNF426 Homo sapiens Q9BUY5
Y2H Array
25416956
种属内
GLRX3 O76003 ZNF426 Homo sapiens Q9BUY5
Validated Y2H
25416956
种属内
GLRX3 O76003 UGP2 Homo sapiens Q16851
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 CBLB Homo sapiens Q13191
Validated Y2H
25416956
种属内
GLRX3 O76003 IKZF1 Homo sapiens Q13422
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 IKZF1 Homo sapiens Q13422
Validated Y2H
25416956
种属内
GLRX3 O76003 COL8A1 Homo sapiens P27658
Validated Y2H
32296183
种属内
GLRX3 O76003 GRN Homo sapiens P28799
Y2H Array
31515488
种属内
GLRX3 O76003 GRN Homo sapiens P28799
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 GRN Homo sapiens P28799
Y2H Array
25416956
种属内
GLRX3 O76003 GRN Homo sapiens P28799
Y2H
21516116
种属内
GLRX3 O76003 GRN Homo sapiens P28799
Validated Y2H
25416956
种属内
GLRX3 O76003 PCSK5 Homo sapiens Q92824
Validated Y2H
25416956
种属内
GLRX3 O76003 FAM118A Homo sapiens Q9NWS6
Y2H Array
25416956
种属内
GLRX3 O76003 MAPKBP1 Homo sapiens O60336
Y2H Array
25416956
种属内
GLRX3 O76003 MAPKBP1 Homo sapiens O60336
Y2H Prey Pooling
25416956
种属内
GLRX3 O76003 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome

Mrx12

Mrx35

X-Linked Mental Retardation 12

X-Linked Mental Retardation 35
Transvestism

Dual-Role Transvestism

Fetishistic Transvestism

Cross Dresser

Transvestic Fetishism
Friedreich Ataxia

Friedreich Ataxia 1

FRDA

Friedreich Ataxia With Retained Reflexes

Frda1

Fa

Friedreich'S Ataxia

Hereditary Spinal Ataxia

Fa1

Friedreich'S Tabes

Hereditary Spinal Sclerosis

Spinocerebellar Ataxia, Friedreich

Friedreich Spinocerebellar Ataxia

Friedrich'S Ataxia
Transposition Of The Great Arteries, Dextro-Looped

Transposition Of The Great Arteries

DTGA1

Dextro-Looped Transposition Of The Great Arteries

DTGA

Congenitally Uncorrected Transposition Of The Great Arteries

Congenitally Uncorrected Transposition Of The Great Vessels

D-Tga

Isolated Ventriculoarterial Discordance

Ventriculoarterial Discordance With Atrioventricular Concordance

Dextro-Transposition Of The Great Arteries

Transposition Of The Great Vessels

Great Vessels Transposition

Transposition Of The Great Arteries, Dextro-Looped 1

Arteries, Great, Transposition, Dextro-Looped

Ventriculoarterial Discordance, Isolated

D-Transposition Of The Great Arteries

Complete Transposition

Tga

Tgv

Transposition Of Great Vessels

Transposition Of The Great Arteries Dextro-Looped 1

Dextro-Looped Transposition Of The Great Arteries 1

Discordant Ventriculoarterial Connection

Complete Transposition Of Great Vessels

Great Vessels Complete Transposition

Total Great Vessel Transposition

Transposition Of Great Arteries

Complete Tga - [Transposition Of The Great Arteries]

Tga - [Transposition Of Great Arteries]

Tgv - [Transposition Of Great Vessels]

Transposition Of Great Vessels Nos

Transposed Vessels Nos
Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05498 GLRX3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GLRX3 MGD MGI:1353653
Macaca mulatta GLRX3 VGNC VGNC:103820
Rattus norvegicus GLRX3 RGD RGD:69414
Canis familiaris GLRX3 VGNC VGNC:41275
Bos taurus GLRX3 VGNC VGNC:29417
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z