2. Gene
  3. SOX7 - SRY-box transcription factor 7 Gene

SOX7 - SRY-box transcription factor 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SRY-box 转录因子 7

种属: Homo sapiens

基因 ID: 83595 | 基因类型: protein coding

关于 SOX7

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:10,723,768-10,730,511 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 203 orthologues and 20 paralogues. Broad expression in placenta (RPKM 14.9), lung (RPKM 8.3) and 19 other tissues.

功能概要

该基因编码参与胚胎发育调控和细胞命运决定的转录因子 SOX (SRY 相关 HMG 盒) 家族成员。编码的蛋白质在与其他蛋白质形成蛋白质复合物后可以充当转录调节剂。该蛋白可能在肿瘤发生中发挥作用。小鼠中的一种类似蛋白质参与无翼型 MMTV 整合位点家族 (Wnt) 通路的调节。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with Other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]

SOX7 基因产物(1)

mRNA Protein Name
NM_031439.4 NP_113627.1 transcription factor SOX-7
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
19108950 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endoderm formation IDA
IDA: 通过直接分析推断
18682240 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
19108950 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
19108950 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
19108950 GOA
involved in regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
19108950 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18819930 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18682240 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SOX7 蛋白结构

HMG_box

HMG_box: HMG (high mobility group) box (45 - 113)

Sox17_18_mid

Sox17_18_mid: Sox 17/18 central domain (177 - 387)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
蛋白主名 其他名称

transcription factor SOX-7

SRY (sex determining region Y)-box 7

SOX7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SOX7 Q9BT81 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra SOX7 Q9BT81 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra SOX7 Q9BT81 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra SOX7 Q9BT81 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypotrichosis-Lymphedema-Telangiectasia Syndrome

HLTS

Hypotrichosis Lymphedema Telangiectasia Syndrome

Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Glomerulonephritis With Sparse Hair And Telangiectases

Telangiectatic Membranoproliferative Glomerulonephritis

HLTRS

Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

Hlt-Renal Defect Syndrome

Glomerulonephritis Sparse Hair Telangiectases
Chromosome 2q31.2 Deletion Syndrome
Diaphragm Disease

Abnormality Of The Diaphragm

Disease Of Diaphragm

Diaphragmatic Disorder

Disorder Of Diaphragm
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia

Diaphragmatic Hernia

Cdh

Congenital Diaphragmatic Defect

Hernia, Diaphragmatic

Dih

Hernia, Congenital Diaphragmatic

Hcd

Diaphragmatic Defect, Congenital

Diaphragm, Unilateral Agenesis Of

Hemidiaphragm, Agenesis Of

Diaphragmatic Hernia 1

Agenesis Of Hemidiaphragm

Unilateral Agenesis Of Diaphragm

Hernia Diaphragmatic

Hernia Diaphragmatic Congenital

Hernia, Diaphragmatic, Type 1

Hiatus Hernia

Oesophageal Hiatus Hernia

Paraoesophageal Hernia

Sliding Hiatus Hernia

Congenital Diaphragm Hernia

Congenital Diaphragm Defect With Hernia

Gross Congenital Diaphragm Defect
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13598 SOX7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SOX7 MGD MGI:98369
Rattus norvegicus SOX7 RGD RGD:1310038
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