UGP2 - UDP-glucose pyrophosphorylase 2 Gene

中文名称：UDP-葡萄糖焦磷酸化酶 2

种属: Homo sapiens

同用名: UDPG; UGP1; DEE83; UDPGP; UGPP1; UGPP2; EIEE83; SVUGP2; UDPGP2; pHC379

基因 ID: 7360 | 基因类型: protein coding

关于 UGP2

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:63,840,969-63,891,560 (from NCBI)

This gene has 39 transcripts (splice variants), 292 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 142.1), fat (RPKM 136.8) and 25 other tissues.

功能概要

由该基因编码的酶是哺乳动物碳水化合物相互转化的重要中介。它将葡萄糖部分从葡萄糖-1-磷酸转移到 MgUTP 并形成 UDP-葡萄糖和 MgPPi。在肝脏和肌肉组织中，UDP-葡萄糖是糖原的直接前体；在哺乳期的乳腺中，它会转化为 UDP-半乳糖，然后再转化为乳糖。真核酶与原核酶没有明显的序列相似性。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

The Enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic Enzyme has no significant sequence similarity to the prokaryotic Enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UGP2 基因产物(8)

mRNA	Protein	Name
NM_001001521.2	NP_001001521.1	UTP--glucose-1-phosphate uridylyltransferase isoform b
NM_001377524.1	NP_001364453.1	UTP--glucose-1-phosphate uridylyltransferase isoform b
NM_001377525.1	NP_001364454.1	UTP--glucose-1-phosphate uridylyltransferase isoform b
NM_001377526.1	NP_001364455.1	UTP--glucose-1-phosphate uridylyltransferase isoform c
NM_001377527.1	NP_001364456.1	UTP--glucose-1-phosphate uridylyltransferase isoform c
NM_001377528.1	NP_001364457.1	UTP--glucose-1-phosphate uridylyltransferase isoform c
NM_001377529.1	NP_001364458.1	UTP--glucose-1-phosphate uridylyltransferase isoform c
NM_006759.4	NP_006750.3	UTP--glucose-1-phosphate uridylyltransferase isoform a

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables UTP:glucose-1-phosphate uridylyltransferase activity	IDA IDA: 通过直接分析推断	22132858	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in UDP-glucose metabolic process	IDA IDA: 通过直接分析推断	8354390	GOA
involved in UDP-glucose metabolic process	IMP IMP: 通过突变表型推断	31820119	GOA
involved in brain development	IMP IMP: 通过突变表型推断	31820119	GOA
involved in glycogen biosynthetic process	IMP IMP: 通过突变表型推断	31820119	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UGP2 蛋白结构

UDPGP

0
100
200
300
400
508 a.a.

蛋白主名

其他名称

UTP--glucose-1-phosphate uridylyltransferase

UDP-glucose diphosphorylase

UGP2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UGP2	Q16851	GLRX3	Homo sapiens	O76003	Validated Y2H	25416956
种属内	UGP2	Q16851	GLRX3	Homo sapiens	O76003	Y2H Array	25416956
种属内	UGP2	Q16851	GRB2	Homo sapiens	P62993	Peptide Array	17474147
种属内	UGP2	Q16851	ARIH2	Homo sapiens	O95376	Y2H Prey Pooling	25416956
种属内	UGP2	Q16851	ARIH2	Homo sapiens	O95376	Y2H Array	25416956
种属内	UGP2	Q16851	ARIH2	Homo sapiens	O95376	Y2H Pooling	16189514
种属内	UGP2	Q16851	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
种属内	UGP2	Q16851	UGP2	Homo sapiens	Q16851	Y2H	21988832
种属内	UGP2	Q16851	UGP2	Homo sapiens	Q16851	Y2H Pooling	16189514
种属内	UGP2	Q16851	UGP2	Homo sapiens	Q16851	Validated Y2H	32296183
种属内	UGP2	Q16851	UGP2	Homo sapiens	Q16851	Y2H Array	25416956
种属内	UGP2	Q16851	UGP2	Homo sapiens	Q16851	Y2H Array	32296183
种属内	UGP2	Q16851	UGP2	Homo sapiens	Q16851	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Developmental And Epileptic Encephalopathy 83

DEE83	Epileptic Encephalopathy, Early Infantile, 83
Eiee83	Barakat-Perenthaler Syndrome
Developmental And Epileptic Encephalopathy, 83	Early Infantile Epileptic Encephalopathy 83
Encephalopathy, Epileptic, Early Infantile, Type 83

Advanced Sleep Phase Syndrome, Familial, 3

Advanced Sleep Phase Syndrome 3	FASPS3
Familial Advanced Sleep Phase Syndrome 3	Sleep Phase Syndrome, Advanced, Familial, Type 3

Galactosemia I

Galactosemia	Galt Deficiency
Classic Galactosemia	Galactose-1-Phosphate Uridylyltransferase Deficiency
Galactose-1-Phosphate Uridyltransferase Deficiency	GALAC1
Galactosemia, Classic	Galactosemia Type 1
Galactosemias	Classical Galactosemia
Galactosaemia	Galactose Intolerance
Epimerase Deficiency Galactosemia	Galactokinase Deficiency Disease
Galactose Epimerase Deficiency	Galactose-1-Phosphate Uridyl-Transferase Deficiency Disease
Gale Deficiency	Galk Deficiency
Udp-Galactose-4-Epimerase Deficiency Disease	Utp Hexose-1-Phosphate Uridylyltransferase Deficiency
Galactosemia 1	Galactosemia, Duarte Variant
Deficiency Of Galactokinase	Udpglucose 4-Epimerase Deficiency Disease
Classical Galactosaemia	Galput Deficiency - [Galactose-4-Phosphate Uridyltransferase] Deficiency
Classic Galactosaemia	Deficiency Of Hexose-1-Phosphate Uridylyltransferase
Deficiency Of Udpglucose-Hexose-1-Phosphate Uridylyltransferase	Deficiency Of Galactose-1-Phosphate Uridylyltransferase
Galactose-1-Phosphate Uridyl Transferase Deficiency	Transferase Deficiency Galactosemia
Deficiency Of Uridyl Transferase	Deficiency Of Utp-Hexose-1-Phosphate Uridylyltransferase
Utp-Hexose-1-Phosphate Uridyltransferase Deficiency

Galactosemia Iii

Galactose Epimerase Deficiency	Gale Deficiency
Udp-Galactose-4-Epimerase Deficiency	Epimerase Deficiency Galactosemia
Galactosemia Type 3	Gale-D
Uridine Diphosphate Galactose-4-Epimerase Deficiency	GALAC3
Galactosemia 3	Generalized Uridine Diphosphate Galactose-4-Epimerase Deficiency
Erythrocyte Uridine Diphosphate Galactose-4-Epimerase Deficiency	Galactosemia Type Iii
Udp-Galactose-4'-Epimerase Deficiency	Generalized Galactose Epimerase Deficiency
Generalized Gale Deficiency	Generalized Gale-D
Generalized Udp-Galactose-4-Epimerase Deficiency	Generalized Epimerase Deficiency Galactosemia
Erythrocyte Galactose Epimerase Deficiency	Erythrocyte Gale Deficiency
Erythrocyte Gale-D	Erythrocyte Udp-Galactose-4-Epimerase Deficiency
Erythrocyte Epimerase Deficiency Galactosemia	Galactosemias
Classical Galactosemia	Udpglucose 4-Epimerase Deficiency Disease

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15425	UGP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	UGP2	VGNC	VGNC:36651
Macaca mulatta	UGP2	VGNC	VGNC:78712
Felis catus	UGP2	VGNC	VGNC:66808
Rattus norvegicus	UGP2	RGD	RGD:1310210
Mus musculus	UGP2	MGD	MGI:2183447
Canis familiaris	UGP2	VGNC	VGNC:48120

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UGP2 - UDP-glucose pyrophosphorylase 2 Gene

关于 UGP2

功能概要

UGP2 基因产物(8)

UGP2 蛋白结构

UGP2 蛋白互作信息

关联疾病

直系同源

热门区域

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UGP2 - UDP-glucose pyrophosphorylase 2 Gene

关于 UGP2

功能概要

UGP2 基因产物(8)

UGP2 蛋白结构

UGP2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z