PLEKHF2 - pleckstrin homology and FYVE domain containing 2 Gene

中文名称：含 pleckstrin 同源性和 FYVE 结构域 2

种属: Homo sapiens

同用名: EAPF; PHAFIN2; ZFYVE18

基因 ID: 79666 | 基因类型: protein coding

关于 PLEKHF2

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:95,133,785-95,156,685 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and 13 paralogues. Broad expression in bone marrow (RPKM 31.1), lymph node (RPKM 29.6) and 24 other tissues.

功能概要

预测可启用磷脂酰肌醇结合活性。预计参与蛋白质运输。位于运输囊泡中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in protein transport. Located in transport vesicle. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHF2 基因产物(1)

mRNA	Protein	Name
NM_024613.4	NP_078889.1	pleckstrin homology domain-containing family F member 2

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLEKHF2 蛋白结构

FYVE

0
100
200
249 a.a.

蛋白主名

其他名称

pleckstrin homology domain-containing family F member 2

PH and FYVE domain-containing protein 2

PLEKHF2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PLEKHF2	Q9H8W4	ZNF250	Homo sapiens	P15622-3	Y2H Prey Pooling	25416956
种属内	PLEKHF2	Q9H8W4	ZNF250	Homo sapiens	P15622-3	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	ZNF250	Homo sapiens	P15622-3	Y2H Array	25416956
种属内	PLEKHF2	Q9H8W4	MBIP	Homo sapiens	Q9NS73-5	Y2H Array	25416956
种属内	PLEKHF2	Q9H8W4	MBIP	Homo sapiens	Q9NS73-5	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	TXNL4B	Homo sapiens	Q9NX01	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	BARHL2	Homo sapiens	Q9NY43	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	SEC14L4	Homo sapiens	Q9UDX3	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	PTPN3	Homo sapiens	P26045	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	PTPN3	Homo sapiens	P26045	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	TNFAIP8	Homo sapiens	O95379	Y2H Prey Pooling	25416956
种属内	PLEKHF2	Q9H8W4	TNFAIP8	Homo sapiens	O95379	Y2H	21516116
种属内	PLEKHF2	Q9H8W4	TNFAIP8	Homo sapiens	O95379	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	TNFAIP8	Homo sapiens	O95379	Y2H Array	25416956
种属内	PLEKHF2	Q9H8W4	RPRM	Homo sapiens	Q9NS64	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	RPRM	Homo sapiens	Q9NS64	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	FGF13	Homo sapiens	Q92913	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	FGF13	Homo sapiens	Q92913	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	GRAMD4	Homo sapiens	Q6IC98	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	GRAMD4	Homo sapiens	Q6IC98	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	ARID4B	Homo sapiens	Q4LE39-3	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	ARID4B	Homo sapiens	Q4LE39-3	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	KRTAP5-4	Homo sapiens	Q6L8H1	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	KRTAP5-4	Homo sapiens	Q6L8H1	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	RASGEF1B	Homo sapiens	Q0VAM2-3	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	RASGEF1B	Homo sapiens	Q0VAM2-3	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	SCYL1	Homo sapiens	Q96KG9-4	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	SCYL1	Homo sapiens	Q96KG9-4	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	SPATA24	Homo sapiens	Q86W54-2	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	SPATA24	Homo sapiens	Q86W54-2	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	MAGI2	Homo sapiens	Q86UL8-2	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	MAGI2	Homo sapiens	Q86UL8-2	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	NFIA	Homo sapiens	Q12857-2	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	NFIA	Homo sapiens	Q12857-2	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	SETBP1	Homo sapiens	Q9Y6X0-2	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	SETBP1	Homo sapiens	Q9Y6X0-2	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	SETBP1	Homo sapiens	Q9Y6X0-2	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	SPEF1	Homo sapiens	Q9Y4P9-2	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	SPEF1	Homo sapiens	Q9Y4P9-2	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	SPEF1	Homo sapiens	Q9Y4P9-2	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	KCNJ5-AS1	Homo sapiens	Q8TAV5	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	KCNJ5-AS1	Homo sapiens	Q8TAV5	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	SNRNP35	Homo sapiens	Q16560-2	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	SNRNP35	Homo sapiens	Q16560-2	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	DOCK3	Homo sapiens	Q8IZD9	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	DOCK3	Homo sapiens	Q8IZD9	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	CHCHD2	Homo sapiens	Q9Y6H1	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	GPBP1	Homo sapiens	Q86WP2	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	SETBP1	Homo sapiens	Q9Y6X0	Y2H Array	25416956
种属内	PLEKHF2	Q9H8W4	SETBP1	Homo sapiens	Q9Y6X0	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	L3MBTL3	Homo sapiens	Q96JM7	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	L3MBTL3	Homo sapiens	Q96JM7	Y2H Array	25416956
种属内	PLEKHF2	Q9H8W4	CCDC25	Homo sapiens	Q86WR0	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	CCDC25	Homo sapiens	Q86WR0	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	NSD2	Homo sapiens	O96028	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	NSD2	Homo sapiens	O96028	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	YIF1A	Homo sapiens	O95070	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	YIF1A	Homo sapiens	O95070	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	EIF3C	Homo sapiens	Q99613	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	EIF3C	Homo sapiens	Q99613	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	TRAF6	Homo sapiens	Q9Y4K3	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	TRAF6	Homo sapiens	Q9Y4K3	Y2H Prey Pooling	25416956
种属内	PLEKHF2	Q9H8W4	XRN2	Homo sapiens	Q9H0D6	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	XRN2	Homo sapiens	Q9H0D6	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	RPE	Homo sapiens	Q96AT9	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	RPE	Homo sapiens	Q96AT9	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	ACY3	Homo sapiens	Q96HD9	Y2H Array	31515488
种属内	PLEKHF2	Q9H8W4	ACY3	Homo sapiens	Q96HD9	Y2H Array	25416956
种属内	PLEKHF2	Q9H8W4	MEAF6	Homo sapiens	Q9HAF1	Y2H Array	25416956
种属内	PLEKHF2	Q9H8W4	DOCK2	Homo sapiens	Q92608	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	DOCK2	Homo sapiens	Q92608	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	BLOC1S6	Homo sapiens	Q9UL45	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	PRKAR1A	Homo sapiens	P10644	Y2H Pooling	19060904
种属内	PLEKHF2	Q9H8W4	PRKAR1A	Homo sapiens	P10644	Y2H Array	19060904
种属内	PLEKHF2	Q9H8W4	FRMD8	Homo sapiens	Q9BZ67	Y2H Prey Pooling	25416956
种属内	PLEKHF2	Q9H8W4	FRMD8	Homo sapiens	Q9BZ67	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	EXOC7	Homo sapiens	Q9UPT5-1	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	EXOC7	Homo sapiens	Q9UPT5-1	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	EXOC7	Homo sapiens	Q9UPT5-1	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	NPM2	Homo sapiens	Q86SE8	Y2H Prey Pooling	25416956
种属内	PLEKHF2	Q9H8W4	NPM2	Homo sapiens	Q86SE8	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	CRYBA1	Homo sapiens	P05813	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	CRYBA1	Homo sapiens	P05813	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	BRD7	Homo sapiens	Q9NPI1	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	BRD7	Homo sapiens	Q9NPI1	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	BRD7	Homo sapiens	Q9NPI1	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	CBX8	Homo sapiens	Q9HC52	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	RPS21	Homo sapiens	P63220	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	RPS21	Homo sapiens	P63220	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	ADAP1	Homo sapiens	O75689	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	ADAP1	Homo sapiens	O75689	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	GFER	Homo sapiens	P55789	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	UBE2Z	Homo sapiens	Q9H832	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	UBE2Z	Homo sapiens	Q9H832	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	PACSIN1	Homo sapiens	Q9BY11	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	PACSIN1	Homo sapiens	Q9BY11	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	S100A13	Homo sapiens	Q99584	Y2H Array	25416956
种属内	PLEKHF2	Q9H8W4	S100A13	Homo sapiens	Q99584	Y2H Prey Pooling	25416956
种属内	PLEKHF2	Q9H8W4	ZBTB6	Homo sapiens	Q15916	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	ZBTB6	Homo sapiens	Q15916	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	PPCDC	Homo sapiens	Q96CD2	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	PPCDC	Homo sapiens	Q96CD2	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	HSPB7	Homo sapiens	Q9UBY9	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	FBXO28	Homo sapiens	Q9NVF7	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	FBXO28	Homo sapiens	Q9NVF7	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	FBXO28	Homo sapiens	Q9NVF7	Y2H Array	25416956
种属内	PLEKHF2	Q9H8W4	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	25416956
种属内	PLEKHF2	Q9H8W4	LDOC1	Homo sapiens	O95751	Y2H Pooling	19060904
种属内	PLEKHF2	Q9H8W4	LDOC1	Homo sapiens	O95751	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	LDOC1	Homo sapiens	O95751	Y2H Array	19060904
种属内	PLEKHF2	Q9H8W4	SEPTIN2	Homo sapiens	Q15019	Y2H Array	25416956
种属内	PLEKHF2	Q9H8W4	SEPTIN2	Homo sapiens	Q15019	Y2H Prey Pooling	25416956
种属内	PLEKHF2	Q9H8W4	SEPTIN2	Homo sapiens	Q15019	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	HEBP2	Homo sapiens	Q9Y5Z4	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	HEBP2	Homo sapiens	Q9Y5Z4	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	HEBP2	Homo sapiens	Q9Y5Z4	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	MMTAG2	Homo sapiens	Q9BU76	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	MMTAG2	Homo sapiens	Q9BU76	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	TRAPPC3	Homo sapiens	O43617	Y2H Prey Pooling	25416956
种属内	PLEKHF2	Q9H8W4	S100A1	Homo sapiens	P23297	Y2H Array	25416956
种属内	PLEKHF2	Q9H8W4	S100A1	Homo sapiens	P23297	Y2H Prey Pooling	25416956
种属内	PLEKHF2	Q9H8W4	UGP2	Homo sapiens	Q16851	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	UGP2	Homo sapiens	Q16851	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	25416956
种属内	PLEKHF2	Q9H8W4	THAP10	Homo sapiens	Q9P2Z0	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	ZNF581	Homo sapiens	Q9P0T4	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	ZNF581	Homo sapiens	Q9P0T4	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	ZNF581	Homo sapiens	Q9P0T4	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	NDUFA5	Homo sapiens	Q16718	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	NDUFA5	Homo sapiens	Q16718	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	THG1L	Homo sapiens	Q9NWX6	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	THG1L	Homo sapiens	Q9NWX6	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	THG1L	Homo sapiens	Q9NWX6	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	MRI1	Homo sapiens	Q9BV20	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	MRI1	Homo sapiens	Q9BV20	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	ZNF439	Homo sapiens	Q8NDP4	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	ZNF439	Homo sapiens	Q8NDP4	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	TNFAIP8L1	Homo sapiens	Q8WVP5	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	TNFAIP8L1	Homo sapiens	Q8WVP5	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	PAK1IP1	Homo sapiens	Q9NWT1	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	YY1	Homo sapiens	P25490	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	YY1	Homo sapiens	P25490	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	INO80	Homo sapiens	Q9ULG1	Validated Y2H	32296183
种属内	PLEKHF2	Q9H8W4	RSPO2	Homo sapiens	Q6UXX9	Validated Y2H	25416956
种属内	PLEKHF2	Q9H8W4	ZNF398	Homo sapiens	Q8TD17	Y2H Prey Pooling	25416956
种属内	PLEKHF2	Q9H8W4	ZNF398	Homo sapiens	Q8TD17	Y2H Array	25416956
种属内	PLEKHF2	Q9H8W4	TRIM22	Homo sapiens	Q8IYM9	Y2H Prey Pooling	32296183
种属内	PLEKHF2	Q9H8W4	TRIM22	Homo sapiens	Q8IYM9	Y2H Array	32296183
种属内	PLEKHF2	Q9H8W4	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10688	PLEKHF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	PLEKHF2	VGNC	VGNC:33013
Rattus norvegicus	PLEKHF2	RGD	RGD:1312029
Macaca mulatta	PLEKHF2	VGNC	VGNC:76084
Felis catus	PLEKHF2	VGNC	VGNC:64225
Mus musculus	PLEKHF2	MGD	MGI:1919051

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4