2. Gene
  3. PLEKHF2 - pleckstrin homology and FYVE domain containing 2 Gene

PLEKHF2 - pleckstrin homology and FYVE domain containing 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含 pleckstrin 同源性和 FYVE 结构域 2

种属: Homo sapiens

同用名: EAPF; PHAFIN2; ZFYVE18

基因 ID: 79666 | 基因类型: protein coding

关于 PLEKHF2

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:95,133,785-95,156,685 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and 13 paralogues. Broad expression in bone marrow (RPKM 31.1), lymph node (RPKM 29.6) and 24 other tissues.

功能概要

预测可启用磷脂酰肌醇结合活性。预计参与蛋白质运输。位于运输囊泡中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in protein transport. Located in transport vesicle. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHF2 基因产物(1)

mRNA Protein Name
NM_024613.4 NP_078889.1 pleckstrin homology domain-containing family F member 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLEKHF2 蛋白结构

PH

PH: PH domain (39 - 130)

FYVE

FYVE: FYVE zinc finger (148 - 211)

  • 0
  • 100
  • 200
  • 249 a.a.
蛋白主名 其他名称

pleckstrin homology domain-containing family F member 2

PH and FYVE domain-containing protein 2

PLEKHF2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PLEKHF2 Q9H8W4 ZNF250 Homo sapiens P15622-3
Y2H Prey Pooling
25416956
种属内
PLEKHF2 Q9H8W4 ZNF250 Homo sapiens P15622-3
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 ZNF250 Homo sapiens P15622-3
Y2H Array
25416956
种属内
PLEKHF2 Q9H8W4 MBIP Homo sapiens Q9NS73-5
Y2H Array
25416956
种属内
PLEKHF2 Q9H8W4 MBIP Homo sapiens Q9NS73-5
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 TXNL4B Homo sapiens Q9NX01
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 BARHL2 Homo sapiens Q9NY43
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 SEC14L4 Homo sapiens Q9UDX3
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 PTPN3 Homo sapiens P26045
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 PTPN3 Homo sapiens P26045
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 TNFAIP8 Homo sapiens O95379
Y2H Prey Pooling
25416956
种属内
PLEKHF2 Q9H8W4 TNFAIP8 Homo sapiens O95379
Y2H
21516116
种属内
PLEKHF2 Q9H8W4 TNFAIP8 Homo sapiens O95379
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 TNFAIP8 Homo sapiens O95379
Y2H Array
25416956
种属内
PLEKHF2 Q9H8W4 RPRM Homo sapiens Q9NS64
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 RPRM Homo sapiens Q9NS64
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 FGF13 Homo sapiens Q92913
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 FGF13 Homo sapiens Q92913
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 GRAMD4 Homo sapiens Q6IC98
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 GRAMD4 Homo sapiens Q6IC98
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 ARID4B Homo sapiens Q4LE39-3
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 ARID4B Homo sapiens Q4LE39-3
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 KRTAP5-4 Homo sapiens Q6L8H1
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 KRTAP5-4 Homo sapiens Q6L8H1
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 RASGEF1B Homo sapiens Q0VAM2-3
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 RASGEF1B Homo sapiens Q0VAM2-3
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 SCYL1 Homo sapiens Q96KG9-4
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 SCYL1 Homo sapiens Q96KG9-4
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 SPATA24 Homo sapiens Q86W54-2
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 SPATA24 Homo sapiens Q86W54-2
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 MAGI2 Homo sapiens Q86UL8-2
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 MAGI2 Homo sapiens Q86UL8-2
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 NFIA Homo sapiens Q12857-2
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 NFIA Homo sapiens Q12857-2
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 SETBP1 Homo sapiens Q9Y6X0-2
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 SETBP1 Homo sapiens Q9Y6X0-2
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 SETBP1 Homo sapiens Q9Y6X0-2
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 SPEF1 Homo sapiens Q9Y4P9-2
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 SPEF1 Homo sapiens Q9Y4P9-2
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 SPEF1 Homo sapiens Q9Y4P9-2
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 KCNJ5-AS1 Homo sapiens Q8TAV5
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 KCNJ5-AS1 Homo sapiens Q8TAV5
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 SNRNP35 Homo sapiens Q16560-2
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 SNRNP35 Homo sapiens Q16560-2
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 DOCK3 Homo sapiens Q8IZD9
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 DOCK3 Homo sapiens Q8IZD9
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 CHCHD2 Homo sapiens Q9Y6H1
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 GPBP1 Homo sapiens Q86WP2
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 SETBP1 Homo sapiens Q9Y6X0
Y2H Array
25416956
种属内
PLEKHF2 Q9H8W4 SETBP1 Homo sapiens Q9Y6X0
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 L3MBTL3 Homo sapiens Q96JM7
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 L3MBTL3 Homo sapiens Q96JM7
Y2H Array
25416956
种属内
PLEKHF2 Q9H8W4 CCDC25 Homo sapiens Q86WR0
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 CCDC25 Homo sapiens Q86WR0
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 NSD2 Homo sapiens O96028
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 NSD2 Homo sapiens O96028
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 YIF1A Homo sapiens O95070
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 YIF1A Homo sapiens O95070
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 EIF3C Homo sapiens Q99613
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 EIF3C Homo sapiens Q99613
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
25416956
种属内
PLEKHF2 Q9H8W4 XRN2 Homo sapiens Q9H0D6
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 XRN2 Homo sapiens Q9H0D6
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 RPE Homo sapiens Q96AT9
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 RPE Homo sapiens Q96AT9
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 ACY3 Homo sapiens Q96HD9
Y2H Array
31515488
种属内
PLEKHF2 Q9H8W4 ACY3 Homo sapiens Q96HD9
Y2H Array
25416956
种属内
PLEKHF2 Q9H8W4 MEAF6 Homo sapiens Q9HAF1
Y2H Array
25416956
种属内
PLEKHF2 Q9H8W4 DOCK2 Homo sapiens Q92608
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 DOCK2 Homo sapiens Q92608
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 BLOC1S6 Homo sapiens Q9UL45
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 PRKAR1A Homo sapiens P10644
Y2H Pooling
19060904
种属内
PLEKHF2 Q9H8W4 PRKAR1A Homo sapiens P10644
Y2H Array
19060904
种属内
PLEKHF2 Q9H8W4 FRMD8 Homo sapiens Q9BZ67
Y2H Prey Pooling
25416956
种属内
PLEKHF2 Q9H8W4 FRMD8 Homo sapiens Q9BZ67
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 EXOC7 Homo sapiens Q9UPT5-1
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 EXOC7 Homo sapiens Q9UPT5-1
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 EXOC7 Homo sapiens Q9UPT5-1
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 NPM2 Homo sapiens Q86SE8
Y2H Prey Pooling
25416956
种属内
PLEKHF2 Q9H8W4 NPM2 Homo sapiens Q86SE8
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 CRYBA1 Homo sapiens P05813
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 CRYBA1 Homo sapiens P05813
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 BRD7 Homo sapiens Q9NPI1
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 BRD7 Homo sapiens Q9NPI1
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 BRD7 Homo sapiens Q9NPI1
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 RPS21 Homo sapiens P63220
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 RPS21 Homo sapiens P63220
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 ADAP1 Homo sapiens O75689
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 ADAP1 Homo sapiens O75689
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 GFER Homo sapiens P55789
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 UBE2Z Homo sapiens Q9H832
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 UBE2Z Homo sapiens Q9H832
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 PACSIN1 Homo sapiens Q9BY11
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 PACSIN1 Homo sapiens Q9BY11
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 S100A13 Homo sapiens Q99584
Y2H Array
25416956
种属内
PLEKHF2 Q9H8W4 S100A13 Homo sapiens Q99584
Y2H Prey Pooling
25416956
种属内
PLEKHF2 Q9H8W4 ZBTB6 Homo sapiens Q15916
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 ZBTB6 Homo sapiens Q15916
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 PPCDC Homo sapiens Q96CD2
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 PPCDC Homo sapiens Q96CD2
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 HSPB7 Homo sapiens Q9UBY9
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 FBXO28 Homo sapiens Q9NVF7
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 FBXO28 Homo sapiens Q9NVF7
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 FBXO28 Homo sapiens Q9NVF7
Y2H Array
25416956
种属内
PLEKHF2 Q9H8W4 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
25416956
种属内
PLEKHF2 Q9H8W4 LDOC1 Homo sapiens O95751
Y2H Pooling
19060904
种属内
PLEKHF2 Q9H8W4 LDOC1 Homo sapiens O95751
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 LDOC1 Homo sapiens O95751
Y2H Array
19060904
种属内
PLEKHF2 Q9H8W4 SEPTIN2 Homo sapiens Q15019
Y2H Array
25416956
种属内
PLEKHF2 Q9H8W4 SEPTIN2 Homo sapiens Q15019
Y2H Prey Pooling
25416956
种属内
PLEKHF2 Q9H8W4 SEPTIN2 Homo sapiens Q15019
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 HEBP2 Homo sapiens Q9Y5Z4
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 HEBP2 Homo sapiens Q9Y5Z4
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 HEBP2 Homo sapiens Q9Y5Z4
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 MMTAG2 Homo sapiens Q9BU76
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 MMTAG2 Homo sapiens Q9BU76
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 TRAPPC3 Homo sapiens O43617
Y2H Prey Pooling
25416956
种属内
PLEKHF2 Q9H8W4 S100A1 Homo sapiens P23297
Y2H Array
25416956
种属内
PLEKHF2 Q9H8W4 S100A1 Homo sapiens P23297
Y2H Prey Pooling
25416956
种属内
PLEKHF2 Q9H8W4 UGP2 Homo sapiens Q16851
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 UGP2 Homo sapiens Q16851
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
25416956
种属内
PLEKHF2 Q9H8W4 THAP10 Homo sapiens Q9P2Z0
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 ZNF581 Homo sapiens Q9P0T4
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 ZNF581 Homo sapiens Q9P0T4
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 ZNF581 Homo sapiens Q9P0T4
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 NDUFA5 Homo sapiens Q16718
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 NDUFA5 Homo sapiens Q16718
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 THG1L Homo sapiens Q9NWX6
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 THG1L Homo sapiens Q9NWX6
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 THG1L Homo sapiens Q9NWX6
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 MRI1 Homo sapiens Q9BV20
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 MRI1 Homo sapiens Q9BV20
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 ZNF439 Homo sapiens Q8NDP4
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 ZNF439 Homo sapiens Q8NDP4
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 TNFAIP8L1 Homo sapiens Q8WVP5
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 TNFAIP8L1 Homo sapiens Q8WVP5
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 PAK1IP1 Homo sapiens Q9NWT1
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 YY1 Homo sapiens P25490
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 YY1 Homo sapiens P25490
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 INO80 Homo sapiens Q9ULG1
Validated Y2H
32296183
种属内
PLEKHF2 Q9H8W4 RSPO2 Homo sapiens Q6UXX9
Validated Y2H
25416956
种属内
PLEKHF2 Q9H8W4 ZNF398 Homo sapiens Q8TD17
Y2H Prey Pooling
25416956
种属内
PLEKHF2 Q9H8W4 ZNF398 Homo sapiens Q8TD17
Y2H Array
25416956
种属内
PLEKHF2 Q9H8W4 TRIM22 Homo sapiens Q8IYM9
Y2H Prey Pooling
32296183
种属内
PLEKHF2 Q9H8W4 TRIM22 Homo sapiens Q8IYM9
Y2H Array
32296183
种属内
PLEKHF2 Q9H8W4 DMRT3 Homo sapiens Q9NQL9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10688 PLEKHF2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PLEKHF2 VGNC VGNC:33013
Rattus norvegicus PLEKHF2 RGD RGD:1312029
Macaca mulatta PLEKHF2 VGNC VGNC:76084
Felis catus PLEKHF2 VGNC VGNC:64225
Mus musculus PLEKHF2 MGD MGI:1919051
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