TRIM22 - tripartite motif containing 22 Gene

中文名称：含三方基序 22

种属: Homo sapiens

同用名: RNF94; STAF50; GPSTAF50

基因 ID: 10346 | 基因类型: protein coding

关于 TRIM22

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:5,689,790-5,710,863 (from NCBI)

This gene has 18 transcripts (splice variants), 40 orthologues and 80 paralogues. Broad expression in spleen (RPKM 83.9), lymph node (RPKM 70.5) and 24 other tissues.

功能概要

由该基因编码的蛋白质是三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。该蛋白定位于细胞质，其表达由干扰素诱导。该蛋白质参与针对不同 DNA 和 RNA 病毒的先天免疫。[RefSeq 提供，2021 年 10 月]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein is involved in innate immunity against different DNA and RNA viruses. [provided by RefSeq, Oct 2021]

TRIM22 基因产物(2)

mRNA	Protein	Name
NM_001199573.2	NP_001186502.1	E3 ubiquitin-protein ligase TRIM22 isoform 2
NM_006074.5	NP_006065.2	E3 ubiquitin-protein ligase TRIM22 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17156811	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25127057	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	25127057	GOA
enables protein-macromolecule adaptor activity	IPI IPI: 通过物理相互作用推断	25127057	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	23077300	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	36159777	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	23077300	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	23077300	GOA
involved in positive regulation of autophagy	IMP IMP: 通过突变表型推断	26347139	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	23077300	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: 通过直接分析推断	36159777	GOA
involved in protein K63-linked ubiquitination	IDA IDA: 通过直接分析推断	36159777	GOA
involved in regulation of protein localization	IMP IMP: 通过突变表型推断	25127057	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	17156811	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17156811	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM22 蛋白结构

zf-C3HC4_4

zf-B_box

SPRY

0
100
200
300
400
498 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase TRIM22

50 kDa-stimulated trans-acting factor

TRIM22 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TRIM22	Q8IYM9	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hepatitis B

Chronic Hepatitis B	Hepatitis B Infection
Serum Hepatitis	HBV
Hepatitis B Chronic	Hbv, Susceptibility To
Hepatitis B, Chronic	Chronic Hepatitis B Without Delta Agent
Chronic Hbv - [Hepatitis B Virus] Infection	Hepatitis B Nos
Chronic Type B Viral Hepatitis	Hep B Nos

Bare Lymphocyte Syndrome, Type Ii

Mhc Class Ii Deficiency	Bare Lymphocyte Syndrome
Major Histocompatibility Complex Class Ii Deficiency	Bare Lymphocyte Syndrome 2
Bare Lymphocyte Syndrome Type 2	Severe Combined Immunodeficiency, Hla Class Ii-Negative
Bare Lymphocyte Syndrome, Type Ii, Complementation Group C	Bare Lymphocyte Syndrome, Type Ii, Complementation Group D
Bare Lymphocyte Syndrome Type Ii	Scid, Hla Class Ii-Negative
Bare Lymphocyte Syndrome, Type Ii, Complementation Group A	Bare Lymphocyte Syndrome, Type Ii, Complementation Group B
Scid Due To Absent Class Ii Hla Antigens	Hla Class 1 Deficiency
Scid, Hla Class 2-Negative	Bls Type Ii
Bare Lymphocyte Syndrome Type 2, Complementation Group A	Bare Lymphocyte Syndrome Type 2, Complementation Group E
Severe Combined Immunodeficiency	Bls, Type Ii
Bls	Bare Lymphocyte Syndrome, Type Ii, Complementation Group E
Blsii	Bls Type 1
Bls 2	Scid Due To Absence Of Class Ii Hla Antigens
Severe Combined Immunodeficiency Due To Absent Class Ii Human Leukocyte Antigens	Immunodeficiency By Defective Expression Of Mhc Class Ii
BLS2	Bare Lymphocyte Syndrome Type Ii Complementation Group A
Bare Lymphocyte Syndrome Type Ii Complementation Group B	Bare Lymphocyte Syndrome Type Ii Complementation Group C
Bare Lymphocyte Syndrome Type Ii Complementation Group D	Bare Lymphocyte Syndrome Type Ii Complementation Group E
Bls Ii	Hereditary Mhc Class Ii Deficiency
Hla Class Ii Deficient Combined Immunodeficiency	Mhc-Ii Deficiency
Scid Hla Class Ii-Negative	Severe Combined Immunodeficiency Hla Class Ii-Negative
Bl-2	Immunodeficiency By Defective Expression Of Hla Class 2
Hla Class 2-Negative Severe Combined Immunodeficiency

Rubella

German Measles	Three Day Measles
Rubella Nos

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

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TRIM22 - tripartite motif containing 22 Gene

关于 TRIM22

功能概要

TRIM22 基因产物(2)

TRIM22 蛋白结构

TRIM22 蛋白互作信息

关联疾病

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TRIM22 - tripartite motif containing 22 Gene

关于 TRIM22

功能概要

TRIM22 基因产物(2)

TRIM22 蛋白结构

TRIM22 蛋白互作信息

关联疾病

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热门区域

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G

H

J

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