2. Gene
  3. LDOC1 - LDOC1 regulator of NFKB signaling Gene

LDOC1 - LDOC1 regulator of NFKB signaling Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NFKB 信号的 LDOC1 调节器

种属: Homo sapiens

同用名: Mar7; RTL7; BCUR1; Mart7; SIRH7

基因 ID: 23641 | 基因类型: protein coding

关于 LDOC1

Cytogenetic location: Xq27.1 Genomic coordinates (GRCh38): X:141,173,235-141,177,129 (from NCBI)

This gene has 3 transcripts (splice variants), 77 orthologues and 10 paralogues.

功能概要

该基因编码的蛋白质包含亮氨酸拉链样基序和富含脯氨酸的区域，与 SH3 结合域具有显着相似性。该蛋白质定位于细胞核并在某些癌细胞系中下调。它被认为调节由核因子 kappa B (NF-kappaB) 介导的转录反应。该基因已被提议作为肿瘤抑制基因，其蛋白质产物可能在某些癌症的发展和/或进展中具有重要作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some Cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]

LDOC1 基因产物(1)

mRNA Protein Name
NM_012317.4 NP_036449.1 protein LDOC1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
27812135 GOA
involved in cellular response to muramyl dipeptide IMP
IMP: 通过突变表型推断
27812135 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein LDOC1

Sushi-Ichi retrotransposon homolog 7

LDOC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LDOC1 O95751 TASOR2 Homo sapiens Q5VWN6-2
Validated Y2H
25416956
Intra LDOC1 O95751 TASOR2 Homo sapiens Q5VWN6-2
Y2H Array
25416956
Intra LDOC1 O95751 ZNF250 Homo sapiens P15622-3
Validated Y2H
32296183
Intra LDOC1 O95751 ZGPAT Homo sapiens Q8N5A5-2
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 ZGPAT Homo sapiens Q8N5A5-2
Y2H Array
25416956
Intra LDOC1 O95751 TSGA10IP Homo sapiens Q3SY00
Validated Y2H
32296183
Intra LDOC1 O95751 RAB7L1 Homo sapiens Q6FGU7
Validated Y2H
25416956
Intra LDOC1 O95751 RAB7L1 Homo sapiens Q6FGU7
Y2H Array
25416956
Intra LDOC1 O95751 ZNF774 Homo sapiens Q6NX45
Y2H Array
25416956
Intra LDOC1 O95751 ZNF774 Homo sapiens Q6NX45
Y2H Array
31515488
Intra LDOC1 O95751 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 LATS1 Homo sapiens Q6PJG3
Y2H Array
25416956
Intra LDOC1 O95751 AEBP2 Homo sapiens Q6ZN18-2
Validated Y2H
32296183
Intra LDOC1 O95751 ZNF564 Homo sapiens Q8TBZ8
Validated Y2H
25416956
Intra LDOC1 O95751 ZNF564 Homo sapiens Q8TBZ8
Y2H Array
25416956
Intra LDOC1 O95751 MFAP1 Homo sapiens P55081
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 MFAP1 Homo sapiens P55081
Validated Y2H
25416956
Intra LDOC1 O95751 MFAP1 Homo sapiens P55081
Validated Y2H
32296183
Intra LDOC1 O95751 MFAP1 Homo sapiens P55081
Y2H Array
25416956
Intra LDOC1 O95751 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra LDOC1 O95751 IQCB1 Homo sapiens Q15051-2
Validated Y2H
32296183
Intra LDOC1 O95751 HDAC4 Homo sapiens P56524-2
Validated Y2H
32296183
Intra LDOC1 O95751 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra LDOC1 O95751 LMO2 Homo sapiens P25791-3
Validated Y2H
32296183
Intra LDOC1 O95751 MBD3 Homo sapiens O95983-2
Validated Y2H
32296183
Intra LDOC1 O95751 ZNF648 Homo sapiens Q5T619
Validated Y2H
32296183
Intra LDOC1 O95751 WDR25 Homo sapiens Q64LD2-2
Validated Y2H
32296183
Intra LDOC1 O95751 PRPF31 Homo sapiens Q8WWY3
Validated Y2H
32296183
Intra LDOC1 O95751 PRPF31 Homo sapiens Q8WWY3
Y2H Array
25416956
Intra LDOC1 O95751 PRPF31 Homo sapiens Q8WWY3
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 UBTFL1 Homo sapiens P0CB47
Validated Y2H
32296183
Intra LDOC1 O95751 HOXC8 Homo sapiens P31273
Validated Y2H
32296183
Intra LDOC1 O95751 FAM110A Homo sapiens Q9BQ89
Validated Y2H
32296183
Intra LDOC1 O95751 TSNAX Homo sapiens Q99598
Validated Y2H
32296183
Intra LDOC1 O95751 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 ZFP1 Homo sapiens Q6P2D0
Validated Y2H
32296183
Intra LDOC1 O95751 ZNF124 Homo sapiens Q15973
Validated Y2H
32296183
Intra LDOC1 O95751 PPP1R18 Homo sapiens Q6NYC8
Validated Y2H
32296183
Intra LDOC1 O95751 PRPF18 Homo sapiens Q99633
Validated Y2H
32296183
Intra LDOC1 O95751 PEG10 Homo sapiens Q86TG7
Validated Y2H
25416956
Intra LDOC1 O95751 PEG10 Homo sapiens Q86TG7
Y2H Array
25416956
Intra LDOC1 O95751 PEG10 Homo sapiens Q86TG7
Anti Tag CoIP
33961781
Intra LDOC1 O95751 HDAC4 Homo sapiens P56524
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 HDAC4 Homo sapiens P56524
Validated Y2H
25416956
Intra LDOC1 O95751 HDAC4 Homo sapiens P56524
Y2H Array
25416956
Intra LDOC1 O95751 TBC1D7 Homo sapiens Q9P0N9
Validated Y2H
25416956
Intra LDOC1 O95751 TBC1D7 Homo sapiens Q9P0N9
Validated Y2H
32296183
Intra LDOC1 O95751 TBC1D7 Homo sapiens Q9P0N9
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 ZGPAT Homo sapiens Q8N5A5
Y2H Array
31515488
Intra LDOC1 O95751 ZGPAT Homo sapiens Q8N5A5
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 ZGPAT Homo sapiens Q8N5A5
Validated Y2H
25416956
Intra LDOC1 O95751 ZGPAT Homo sapiens Q8N5A5
Y2H Array
25416956
Intra LDOC1 O95751 ZNF408 Homo sapiens Q9H9D4
Y2H Pooling
16189514
Intra LDOC1 O95751 ZNF408 Homo sapiens Q9H9D4
Y2H Array
19060904
Intra LDOC1 O95751 ZNF408 Homo sapiens Q9H9D4
Y2H Pooling
19060904
Intra LDOC1 O95751 BYSL Homo sapiens Q13895
Validated Y2H
32296183
Intra LDOC1 O95751 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra LDOC1 O95751 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 PSMA1 Homo sapiens P25786
Validated Y2H
25416956
Intra LDOC1 O95751 PSMA1 Homo sapiens P25786
Validated Y2H
32296183
Intra LDOC1 O95751 PSMA1 Homo sapiens P25786
Y2H Array
25416956
Intra LDOC1 O95751 DPF2 Homo sapiens Q92785
Validated Y2H
32296183
Intra LDOC1 O95751 DPF2 Homo sapiens Q92785
Y2H Array
25416956
Intra LDOC1 O95751 DPF2 Homo sapiens Q92785
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 RPP25 Homo sapiens Q9BUL9
Validated Y2H
32296183
Intra LDOC1 O95751 GADD45GIP1 Homo sapiens Q8TAE8
Validated Y2H
32296183
Intra LDOC1 O95751 CDC5L Homo sapiens Q99459
Validated Y2H
32296183
Intra LDOC1 O95751 HOXB5 Homo sapiens P09067
Validated Y2H
32296183
Intra LDOC1 O95751 NXF1 Homo sapiens Q9UBU9
Y2H Array
25416956
Intra LDOC1 O95751 NXF1 Homo sapiens Q9UBU9
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 MEAF6 Homo sapiens Q9HAF1
Y2H Array
25416956
Intra LDOC1 O95751 MEAF6 Homo sapiens Q9HAF1
Validated Y2H
25416956
Intra LDOC1 O95751 BARD1 Homo sapiens Q99728
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 BARD1 Homo sapiens Q99728
Validated Y2H
32296183
Intra LDOC1 O95751 BARD1 Homo sapiens Q99728
Y2H Array
25416956
Intra LDOC1 O95751 UTP14A Homo sapiens Q9BVJ6
Y2H Array
31515488
Intra LDOC1 O95751 ABLIM1 Homo sapiens O14639
Y2H Pooling
16189514
Intra LDOC1 O95751 ATF4 Homo sapiens P18848
Y2H Array
31515488
Intra LDOC1 O95751 ATF4 Homo sapiens P18848
Validated Y2H
25416956
Intra LDOC1 O95751 ATF4 Homo sapiens P18848
Y2H Array
29892012
Intra LDOC1 O95751 SUDS3 Homo sapiens Q9H7L9
Validated Y2H
32296183
Intra LDOC1 O95751 AP1M1 Homo sapiens Q9BXS5
Y2H Array
19060904
Intra LDOC1 O95751 AP1M1 Homo sapiens Q9BXS5
Y2H Pooling
19060904
Intra LDOC1 O95751 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
32296183
Intra LDOC1 O95751 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Intra LDOC1 O95751 PEG10 Homo sapiens Q86TG7-2
Validated Y2H
32296183
Intra LDOC1 O95751 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra LDOC1 O95751 TTC23 Homo sapiens Q5W5X9
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 TTC23 Homo sapiens Q5W5X9
Y2H Array
25416956
Intra LDOC1 O95751 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
25416956
Intra LDOC1 O95751 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra LDOC1 O95751 DPPA4 Homo sapiens Q7L190
Validated Y2H
25416956
Intra LDOC1 O95751 DPPA4 Homo sapiens Q7L190
Y2H Pooling
16189514
Intra LDOC1 O95751 DPPA4 Homo sapiens Q7L190
Validated Y2H
32296183
Intra LDOC1 O95751 ATP6V1G1 Homo sapiens O75348
Y2H Array
25416956
Intra LDOC1 O95751 ATP6V1G1 Homo sapiens O75348
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 ZBTB16 Homo sapiens Q05516
Validated Y2H
32296183
Intra LDOC1 O95751 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra LDOC1 O95751 FAM161A Homo sapiens Q3B820
Validated Y2H
32296183
Intra LDOC1 O95751 LENG1 Homo sapiens Q96BZ8
Y2H Array
31515488
Intra LDOC1 O95751 LENG1 Homo sapiens Q96BZ8
Validated Y2H
32296183
Intra LDOC1 O95751 SDCBP Homo sapiens O00560
Y2H Array
25416956
Intra LDOC1 O95751 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra LDOC1 O95751 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 HGS Homo sapiens O14964
Y2H Array
25416956
Intra LDOC1 O95751 HGS Homo sapiens O14964
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 HGS Homo sapiens O14964
Validated Y2H
25416956
Intra LDOC1 O95751 FXR2 Homo sapiens P51116
Y2H Pooling
19060904
Intra LDOC1 O95751 FXR2 Homo sapiens P51116
Y2H Array
19060904
Intra LDOC1 O95751 THAP7 Homo sapiens Q9BT49
Validated Y2H
32296183
Intra LDOC1 O95751 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra LDOC1 O95751 CFAP53 Homo sapiens Q96M91
Validated Y2H
32296183
Intra LDOC1 O95751 FAM50B Homo sapiens Q9Y247
Y2H Pooling
19060904
Intra LDOC1 O95751 FAM50B Homo sapiens Q9Y247
Validated Y2H
32296183
Intra LDOC1 O95751 FAM50B Homo sapiens Q9Y247
Y2H Array
19060904
Intra LDOC1 O95751 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra LDOC1 O95751 ZBTB24 Homo sapiens O43167
Y2H Array
25416956
Intra LDOC1 O95751 ZBTB24 Homo sapiens O43167
Y2H Array
32296183
Intra LDOC1 O95751 BEX2 Homo sapiens Q9BXY8
Validated Y2H
32296183
Intra LDOC1 O95751 AQP1 Homo sapiens P29972
Validated Y2H
32296183
Intra LDOC1 O95751 GNL3L Homo sapiens Q9NVN8
Y2H Pooling
16189514
Intra LDOC1 O95751 GNL3L Homo sapiens Q9NVN8
Validated Y2H
32296183
Intra LDOC1 O95751 SH2D4A Homo sapiens Q9H788
Y2H Array
25416956
Intra LDOC1 O95751 SH2D4A Homo sapiens Q9H788
Y2H Array
31515488
Intra LDOC1 O95751 SH2D4A Homo sapiens Q9H788
Validated Y2H
25416956
Intra LDOC1 O95751 SH2D4A Homo sapiens Q9H788
Validated Y2H
32296183
Intra LDOC1 O95751 TEAD4 Homo sapiens Q15561
Validated Y2H
32296183
Intra LDOC1 O95751 CTNNBL1 Homo sapiens Q8WYA6
Validated Y2H
25416956
Intra LDOC1 O95751 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra LDOC1 O95751 RALBP1 Homo sapiens Q15311
Validated Y2H
32296183
Intra LDOC1 O95751 GPANK1 Homo sapiens O95872
Validated Y2H
32296183
Intra LDOC1 O95751 TTC23 Homo sapiens Q5W5X9-3
Validated Y2H
32296183
Intra LDOC1 O95751 ZNF629 Homo sapiens Q9UEG4
Validated Y2H
32296183
Intra LDOC1 O95751 BARD1 Homo sapiens A0AVN2
Y2H Prey Pooling
25416956
Intra LDOC1 O95751 BARD1 Homo sapiens A0AVN2
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Familial Febrile Seizures

Familial Febrile Convulsions

Feb

Febrile Seizures, Familial
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07581 LDOC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus LDOC1 MGD MGI:2685212
Canis familiaris LDOC1 VGNC VGNC:42627
Rattus norvegicus LDOC1 RGD RGD:1565644
Macaca mulatta LDOC1 VGNC VGNC:74249
Felis catus LDOC1 VGNC VGNC:68032
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