ATF4 - activating transcription factor 4 Gene

中文名称：激活转录因子 4

种属: Homo sapiens

同用名: CREB2; TXREB; CREB-2; TAXREB67

基因 ID: 468 | 基因类型: protein coding

关于 ATF4

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,520,559-39,522,686 (from NCBI)

This gene has 11 transcripts (splice variants), 269 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 183.9), fat (RPKM 87.6) and 25 other tissues.

功能概要

该基因编码的转录因子最初被鉴定为广泛表达的哺乳动物 DNA 结合蛋白，可结合 HTLV-1 LTR 中的税反应增强子元件。编码的蛋白质也被分离并表征为 cAMP 反应元件结合蛋白 2 (CREB-2) 。该基因编码的蛋白质属于 DNA 结合蛋白家族，包括 AP-1 转录因子家族、cAMP 反应元件结合蛋白 (CREB) 和 CREB 样蛋白。这些转录因子共享一个参与蛋白质-蛋白质相互作用的亮氨酸拉链区域，该区域位于一段碱性氨基酸的 C 端，充当 DNA 结合域。已经描述了编码相同蛋白质的两种替代转录物。两个假基因位于 X 染色体 q28 的一个区域，该区域包含一个大的倒置重复。[RefSeq 提供，2011 年 9 月]

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic Amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

ATF4 基因产物(2)

mRNA	Protein	Name
NM_001675.4	NP_001666.2	cyclic AMP-dependent transcription factor ATF-4
NM_182810.3	NP_877962.1	cyclic AMP-dependent transcription factor ATF-4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	15788408	GOA
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	11960987	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	11478948	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	11478948	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16343488	GOA
enables leucine zipper domain binding	IDA IDA: 通过直接分析推断	11478948	GOA
enables promoter-specific chromatin binding	IDA IDA: 通过直接分析推断	17267404	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9488481	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	20873783	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	22915762	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
contributes to transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	12871976	GOA
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	21113145	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in HRI-mediated signaling	IDA IDA: 通过直接分析推断	32132706	GOA
involved in L-asparagine metabolic process	IDA IDA: 通过直接分析推断	11960987	GOA
involved in cellular response to glucose starvation	IMP IMP: 通过突变表型推断	22915762	GOA
involved in cellular response to leucine starvation	IDA IDA: 通过直接分析推断	17267404	GOA
involved in cellular response to oxidative stress	IMP IMP: 通过突变表型推断	21113145	GOA
involved in integrated stress response signaling	IDA IDA: 通过直接分析推断	32132707	GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IGI IGI: 通过遗传相互作用推断	23392669	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15775988	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	11960987	GOA
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	16445384	GOA
involved in positive regulation of transcription by RNA polymerase I	IMP IMP: 通过突变表型推断	22915762	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	11478948	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	15788408	GOA
involved in positive regulation of vascular endothelial growth factor production	IMP IMP: 通过突变表型推断	22915762	GOA
involved in regulation of osteoblast differentiation	IDA IDA: 通过直接分析推断	15109498	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	12871976	GOA
involved in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	21113145	GOA
involved in response to nutrient levels	IDA IDA: 通过直接分析推断	11960987	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of ATF1-ATF4 transcription factor complex	IDA IDA: 通过直接分析推断	12871976	GOA
part of ATF4-CREB1 transcription factor complex	IDA IDA: 通过直接分析推断	12871976	GOA
part of CHOP-ATF4 complex	IDA IDA: 通过直接分析推断	11478948	GOA
part of CHOP-ATF4 complex	IPI IPI: 通过物理相互作用推断	18940792	GOA
located in Lewy body core	IDA IDA: 通过直接分析推断	23392669	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: 通过物理相互作用推断	20102225	GOA
colocalizes with centrosome	IDA IDA: 通过直接分析推断	20873783	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	23392669	GOA
located in neuron projection	IDA IDA: 通过直接分析推断	23392669	GOA
located in nuclear periphery	IDA IDA: 通过直接分析推断	23392669	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11478948	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	20873783	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATF4 蛋白结构

bZIP_1

0
100
200
300
351 a.a.

蛋白主名

其他名称

cyclic AMP-dependent transcription factor ATF-4

DNA-binding protein TAXREB67

关联疾病

疾病名称

别名

Coffin-Lowry Syndrome

CLS	Coffin Syndrome 1
Coffin Syndrome	Intellectual Disability With Osteocartilaginous Abnormalities
Dwarfism, Lean Spastic Type	Lean Spastic Dwarfism
Mental Retardation With Osteocartilaginous Abnormalities	Coffin Lowry Syndrome

Fatty Liver Disease

Alcoholic Fatty Liver	Fatty Liver
Fatty Liver, Alcoholic	Fatty Change Of Liver
Hepatic Lipidosis	Steatosis Of Liver
Fatty Liver Alcoholic	Steatohepatitis
Etoh Fatty Liver	Etoh Fatty Liver Metamorphosis
Fatty Etoh Liver Necrosis

Liver Disease

Liver Failure	Liver Diseases
Abnormality Of The Liver	Liver Dysfunction
Disorder Of Liver	Hepatic Disorder
Hepatic Disease	Disease Of Bilirubin Metabolism
Disorder Of Bilirubin Metabolism	Liver Decompensation
Liver Function Failure	Hepatic Failure Nos
Liver Failure Nos	End Stage Liver Disease
Decompensated Liver Failure	Decompensation Of Liver Function
Hepatic Decompensation	Hepatic Insufficiency
Liver Cell Necrosis With Hepatic Failure	Liver Insufficiency
Decompensated Liver Disease	End Stage Liver Failure
Liver Necrosis With Hepatic Failure

Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus

Wolcott-Rallison Syndrome	Med-Iddm Syndrome
Iddm-Med Syndrome	Wolcott Rallison Syndrome
WRS	Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus
Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia	Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus

Leukodystrophy

Leukodystrophies

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-13559	Atiprimod		/	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100548	GSK621		98.02%	否
HY-153339	E235		98.85%	否
HY-153340	I-152	Activator	98.78%	否
HY-153074	ISR-IN-1		98.25%	否
HY-124646	KIRA-7	Inhibitor	98.33%	否
HY-153075	ISR-IN-2		98.21%	否
HY-158201	ATF4-IN-1	Activator	98.02%	否
HY-121337	Flurochloridone		99.61%	否
HY-158202	ATF4-IN-2		/	否
HY-158204	CNB-001	Inhibitor	/	否
HY-149918	Antiproliferative agent-23		/	否
HY-117938	T-3861174	Inhibitor	/	否
HY-158195	DPP23		/	否
HY-158196	PERK/eIF2α activator 1	Activator	/	否
HY-158203	BMP agonist 2		99.26%	否
HY-158205	HPO-DAEE		/	否
HY-162886	BSO-07	Activator	/	否
HY-RS01130	ATF4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-112654A	GCN2iB acetate		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ATF4	RGD	RGD:621863
Mus musculus	ATF4	MGD	MGI:88096
Canis familiaris	ATF4	VGNC	VGNC:38210
Bos taurus	ATF4	VGNC	VGNC:26242
Macaca mulatta	ATF4	VGNC	VGNC:107770
Felis catus	ATF4	VGNC	VGNC:68509

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