1. Gene
  2. POLR2C - RNA polymerase II subunit C Gene

POLR2C - RNA polymerase II subunit C Gene

中文名称:RNA 聚合酶 II 亚基 C

种属: Homo sapiens

同用名: RPB3; RPB31; hRPB33; hsRPB3

基因 ID: 5432 | 基因类型: protein coding

关于 POLR2C

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,462,679-57,472,009 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 43.5), adrenal (RPKM 39.1) and 25 other tissues.

功能概要

该基因编码 RNA 聚合酶 II 的第三大亚基,该聚合酶负责在真核生物中合成信使 RNA。该基因的产物含有富含半胱氨酸的区域,并与另一个聚合酶亚基 POLR2J 以异二聚体形式存在。这两个亚基构成了聚合酶的核心子组装单元。已在 21 号染色体上鉴定出假基因。[RefSeq 提供,2008 年 7 月]

This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]

POLR2C 基因产物(1)

mRNA Protein Name
NM_032940.3 NP_116558.1 DNA-directed RNA polymerase II subunit RPB3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12860379 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9852112 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II, core complex IDA
IDA: 通过直接分析推断
9852112 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9852112 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

POLR2C 蛋白结构

RNA_pol_L

RNA_pol_L: RNA polymerase Rpb3/Rpb11 dimerisation domain (20 - 256)

RNA_pol_A_bac

RNA_pol_A_bac: RNA polymerase Rpb3/RpoA insert domain (50 - 177)

  • 0
  • 100
  • 200
  • 275 a.a.
蛋白主名 其他名称

DNA-directed RNA polymerase II subunit RPB3

DNA-directed RNA polymerase II 33 kDa polypeptide

POLR2C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
POLR2C P19387 ATF4 Homo sapiens P18848
Y2H
12860379
种属内
POLR2C P19387 ATF4 Homo sapiens P18848
Pull Down
12860379
种属间: 跨种属相互作用 种属内: 同种属相互作用

POLR2C 抗体

目录号 产品名 应用 反应物种
HY-P82702 RNA Polymerase II Subunit B3 Antibody (YA2447) WB, IHC-P Human, Mouse, Rat

关联疾病

疾病名称 别名
Immunodeficiency 25

Immunodeficiency Due To Defect In Cd3-Zeta

IMD25

Immunodeficiency, Type 25

Nemaline Myopathy 7

NEM7

Nemaline Myopathy 7, Autosomal Recessive

Cfl2-Related Nemaline Myopathy

Myopathy, Nemaline, Type 7

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus POLR2C RGD RGD:1306935
Macaca mulatta POLR2C VGNC VGNC:76212
Bos taurus POLR2C VGNC VGNC:33137
Canis familiaris POLR2C VGNC VGNC:44794
Mus musculus POLR2C MGD MGI:109299