2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage
  3. Reactive Oxygen Species HDAC SOD
  4. HPO-DAEE

HPO-DAEE  (Synonyms: 4-Hydroperoxy-2-decenoic acid ethyl ester)

目录号: HY-158205
产品使用指南 技术支持

HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) 会引起 Nrf2 的核积累并激活抗氧化反应元件 (ARE)。HPO-DAEE 通过 Nrf2-ARE 信号传导诱导抗氧化基因上调 (例如: HO-1)。HPO-DAEE 诱导活性氧(reactive oxygen species) 的产生。HPO-DAEE 还抑制组蛋白脱乙酰酶并通过组蛋白乙酰化上调细胞外超氧化物歧化酶的表达。HPO-DAEE 通过激活 Nrf2-ARE 和 eIF2α-ATF4 途径防止 6-羟基多巴胺诱导的细胞死亡。

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HPO-DAEE Chemical Structure

HPO-DAEE Chemical Structure

CAS No. : 1895934-61-8

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HPO-DAEE 相关抗体

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) elicits nuclear accumulation of Nrf2 and activated antioxidant response element (ARE). HPO-DAEE induces antioxidant genes upregulation (eg: HO-1) through Nrf2-ARE signaling. HPO-DAEE induces reactive oxygen species generation. HPO-DAEE also inhibits histone deacetylase and upregulate expression of extracellular superoxide dismutase via histone acetylation. HPO-DAEE protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways[1].

分子量

230.30

Formula

C12H22O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HPO-DAEE 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPO-DAEE1895934-61-84-Hydroperoxy-2-decenoic acid ethyl esterReactive Oxygen SpeciesHDACSODHistone deacetylasesSuperoxide DismutaseParkinson’s diseasereactive oxygen speciespreconditioningNrf2ATF4Inhibitorinhibitorinhibit

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