JUNB - JunB proto-oncogene, AP-1 transcription factor subunit Gene

中文名称：JunB 原癌基因，AP-1 转录因子亚单位

种属: Homo sapiens

同用名: AP-1

基因 ID: 3726 | 基因类型: protein coding

关于 JUNB

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,791,486-12,793,315 (from NCBI)

This gene has 1 transcript (splice variant), 236 orthologues and 2 paralogues.

功能概要

启用序列特异性双链 DNA 结合活性。参与 RNA 聚合酶 II 对转录的正调控。位于核质中。转录因子 AP-1 复合体的一部分。霍奇金淋巴瘤和间变性大细胞淋巴瘤的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription factor AP-1 complex. Biomarker of Hodgkin's lymphoma and anaplastic large cell lymphoma. [provided by Alliance of Genome Resources, Apr 2022]

JUNB 基因产物(1)

mRNA	Protein	Name
NM_002229.3	NP_002220.1	transcription factor JunB

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	10508860	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA polymerase II transcription regulator complex	IPI IPI: 通过物理相互作用推断	20102225	GOA
part of transcription factor AP-1 complex	IDA IDA: 通过直接分析推断	10508860	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

JUNB 蛋白结构

Jun

bZIP_1

0
100
200
300
347 a.a.

蛋白主名

其他名称

transcription factor JunB

activator protein 1	jun B proto-oncogene
transcription factor AP-1 subunit JunB	transcription factor jun-B

JUNB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	JUNB	P17275	FOS	Homo sapiens	Q6FG41	Y2H Prey Pooling	25416956
种属内	JUNB	P17275	BATF3	Homo sapiens	Q9NR55	Y2H Array	20211142
种属内	JUNB	P17275	BATF3	Homo sapiens	Q9NR55	FRET	23661758
种属内	JUNB	P17275	BATF3	Homo sapiens	Q9NR55	Peptide Array	20102225
种属内	JUNB	P17275	BATF3	Homo sapiens	Q9NR55	Anti Tag CoIP	35271311
种属内	JUNB	P17275	ATF2	Homo sapiens	P15336	Anti Tag CoIP	33961781
种属内	JUNB	P17275	ATF2	Homo sapiens	P15336	Peptide Array	20102225
种属内	JUNB	P17275	ATF2	Homo sapiens	P15336	Anti Tag CoIP	28514442
种属内	JUNB	P17275	JDP2	Homo sapiens	Q8WYK2	Y2H Array	20211142
种属内	JUNB	P17275	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
种属内	JUNB	P17275	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
种属内	JUNB	P17275	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
种属内	JUNB	P17275	FOSB	Homo sapiens	P53539	Y2H Prey Pooling	32296183
种属内	JUNB	P17275	FOSB	Homo sapiens	P53539	Validated Y2H	32296183
种属内	JUNB	P17275	FOSB	Homo sapiens	P53539	Y2H Array	32296183
种属内	JUNB	P17275	FOSB	Homo sapiens	P53539	Anti Tag CoIP	33961781
种属内	JUNB	P17275	FOSB	Homo sapiens	P53539	Anti Tag CoIP	28514442
种属内	JUNB	P17275	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
种属内	JUNB	P17275	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
种属内	JUNB	P17275	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
种属内	JUNB	P17275	FOSL2	Homo sapiens	P15408	Anti Tag CoIP	33961781
种属内	JUNB	P17275	FOSL2	Homo sapiens	P15408	Anti Tag CoIP	28514442
种属内	JUNB	P17275	FOSL2	Homo sapiens	P15408	Y2H Prey Pooling	32296183
种属内	JUNB	P17275	FOSL2	Homo sapiens	P15408	Peptide Array	20102225
种属内	JUNB	P17275	FOSL2	Homo sapiens	P15408	Y2H Array	32296183
种属内	JUNB	P17275	ATF4	Homo sapiens	P18848	FRET	23661758
种属内	JUNB	P17275	ATF3	Homo sapiens	P18847	Peptide Array	20102225
种属内	JUNB	P17275	ATF3	Homo sapiens	P18847	FRET	23661758
种属内	JUNB	P17275	ATF3	Homo sapiens	P18847	Anti Tag CoIP	33961781
种属内	JUNB	P17275	ATF3	Homo sapiens	P18847	Anti Tag CoIP	28514442
种属内	JUNB	P17275	DDIT3	Homo sapiens	P35638	FRET	23661758
种属内	JUNB	P17275	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
种属内	JUNB	P17275	BATF2	Homo sapiens	Q8N1L9	FRET	23661758
种属内	JUNB	P17275	BATF2	Homo sapiens	Q8N1L9	Y2H Array	21988832
种属内	JUNB	P17275	BATF2	Homo sapiens	Q8N1L9	Confocal	21988832
种属内	JUNB	P17275	FOSL1	Homo sapiens	P15407	Y2H Prey Pooling	32296183
种属内	JUNB	P17275	FOSL1	Homo sapiens	P15407	Y2H Pooling	16189514
种属内	JUNB	P17275	FOSL1	Homo sapiens	P15407	FRET	23661758
种属内	JUNB	P17275	FOSL1	Homo sapiens	P15407	Y2H Array	32296183
种属内	JUNB	P17275	FOSL1	Homo sapiens	P15407	Anti Tag CoIP	33961781
种属内	JUNB	P17275	BATF	Homo sapiens	Q16520	Y2H Array	25416956
种属内	JUNB	P17275	BATF	Homo sapiens	Q16520	FRET	23661758
种属内	JUNB	P17275	BATF	Homo sapiens	Q16520	Y2H Prey Pooling	25416956
种属内	JUNB	P17275	BATF	Homo sapiens	Q16520	SLC	31467278
种属内	JUNB	P17275	BATF	Homo sapiens	Q16520	Lumier	29997244
种属内	JUNB	P17275	BATF	Homo sapiens	Q16520	Y2H Array	31467278
种属内	JUNB	P17275	BATF	Homo sapiens	Q16520	Y2H Pooling	18692475
种属内	JUNB	P17275	BATF	Homo sapiens	Q16520	Peptide Array	20102225
种属内	JUNB	P17275	BATF	Homo sapiens	Q16520	BRET	29997244
种属内	JUNB	P17275	TCL1A	Homo sapiens	P56279	Anti Bait CoIP	19064921
种属内	JUNB	P17275	TCL1A	Homo sapiens	P56279	Anti Tag CoIP	19064921
种属内	JUNB	P17275	ATF7	Homo sapiens	P17544	Peptide Array	20102225
种属内	JUNB	P17275	ATF7	Homo sapiens	P17544	Anti Tag CoIP	33961781
种属内	JUNB	P17275	FOS	Homo sapiens	P01100	Complementation	16511568
种属内	JUNB	P17275	FOS	Homo sapiens	P01100	FRET	23661758
种属内	JUNB	P17275	FOS	Homo sapiens	P01100	Display Tech	20195357
种属内	JUNB	P17275	FOS	Homo sapiens	P01100	Peptide Array	20102225
种属间	JUNB	P17275	MDV005	Gallid herpesvirus 2	Q9DGW5	Peptide Array	20102225
种属间	JUNB	P17275	HBZ	Human T-cell leukemia virus 1	P0C746	Peptide Array	20102225

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Scirrhous Carcinoma

Infiltrating Carcinoma Of Breast With Fibrotic Stroma

Scirrhous Carcinoma Of Breast

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Anaplastic Large Cell Lymphoma

Alcl	Cd30 Positive Anaplastic Large Cell Lymphoma
Ki-1 Positive Anaplastic Large Cell Lymphoma	Primary Systemic Alcl
Sacl	Ki-1+ Anaplastic Large Cell Lymphoma

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07057	JUNB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07058	Junb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07059	Junb Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	JUNB	VGNC	VGNC:73959
Rattus norvegicus	JUNB	RGD	RGD:2944
Felis catus	JUNB	VGNC	VGNC:67882
Mus musculus	JUNB	MGD	MGI:96647
Canis familiaris	JUNB	VGNC	VGNC:42198
Bos taurus	JUNB	VGNC	VGNC:30387

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