2. Gene
  3. ATF7 - activating transcription factor 7 Gene

ATF7 - activating transcription factor 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：激活转录因子 7

种属: Homo sapiens

同用名: ATFA

基因 ID: 11016 | 基因类型: protein coding

关于 ATF7

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,507,856-53,626,382 (from NCBI)

This gene has 12 transcripts (splice variants), 280 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 9.8), fat (RPKM 9.2) and 25 other tissues.

功能概要

启用多种功能，包括 DNA 结合转录抑制活性、RNA 聚合酶 II 特异性；有丝分裂原活化蛋白激酶结合活性；和转录辅激活因子结合活性。参与 RNA 聚合酶 II 转录的负调节和 RNA 聚合酶 II 转录的正调节。位于核质中。结直肠癌的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Biomarker of colorectal Cancer. [provided by Alliance of Genome Resources, Apr 2022]

ATF7 基因产物(10)

mRNA Protein Name
NM_001130060.2 NP_001123532.1 cyclic AMP-dependent transcription factor ATF-7 isoform 3
NM_001206682.2 NP_001193611.1 cyclic AMP-dependent transcription factor ATF-7 isoform 4
NM_001206683.1 NP_001193612.1 cyclic AMP-dependent transcription factor ATF-7 isoform 4
NM_001366555.2 NP_001353484.1 cyclic AMP-dependent transcription factor ATF-7 isoform 5
NM_001366556.2 NP_001353485.1 cyclic AMP-dependent transcription factor ATF-7 isoform 2
NM_001366558.2 NP_001353487.1 cyclic AMP-dependent transcription factor ATF-7 isoform 2
NM_001366561.2 NP_001353490.1 cyclic AMP-dependent transcription factor ATF-7 isoform 8
NM_001366562.2 NP_001353491.1 cyclic AMP-dependent transcription factor ATF-7 isoform 4
NM_001366563.2 NP_001353492.1 cyclic AMP-dependent transcription factor ATF-7 isoform 9
NM_006856.3 NP_006847.1 cyclic AMP-dependent transcription factor ATF-7 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
8288576 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8288576 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
23382074 GOA
enables mitogen-activated protein kinase binding IDA
IDA: 通过直接分析推断
10376527 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10376527 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
17264123 GOA
enables transcription coactivator binding IDA
IDA: 通过直接分析推断
17264123 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8288576 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17264123 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
8288576 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IPI
IPI: 通过物理相互作用推断
20102225 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
17264123 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATF7 蛋白结构

bZIP_1

bZIP_1: bZIP transcription factor (343 - 402)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
蛋白主名 其他名称

cyclic AMP-dependent transcription factor ATF-7

transcription factor ATF-A

ATF7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ATF7 P17544 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra ATF7 P17544 BACH1 Homo sapiens O14867
Peptide Array
20102225
Intra ATF7 P17544 JUND Homo sapiens P17535
Peptide Array
20102225
Intra ATF7 P17544 OCIAD1 Homo sapiens Q9NX40
Display Tech
20195357
Intra ATF7 P17544 FOSL2 Homo sapiens P15408
Peptide Array
20102225
Intra ATF7 P17544 ATF3 Homo sapiens P18847
Peptide Array
20102225
Intra ATF7 P17544 CEBPG Homo sapiens P53567
Peptide Array
20102225
Intra ATF7 P17544 DDIT3 Homo sapiens P35638
Peptide Array
20102225
Intra ATF7 P17544 JUNB Homo sapiens P17275
Peptide Array
20102225
Intra ATF7 P17544 KASH5 Homo sapiens Q8N6L0
Validated Y2H
25416956
Intra ATF7 P17544 JUN Homo sapiens P05412
Peptide Array
20102225
Intra ATF7 P17544 FOS Homo sapiens P01100
Peptide Array
20102225
Intra ATF7 P17544 TMEM239 Homo sapiens Q8WW34
Validated Y2H
25416956
Intra ATF7 P17544 TMEM239 Homo sapiens Q8WW34
Y2H Array
25416956
Cross ATF7 P17544 MDV005 Gallid herpesvirus 2 Q9DGW5
Peptide Array
20102225
Cross ATF7 P17544 HBZ Human T-cell leukemia virus 1 P0C746
Peptide Array
20102225
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Penicilliosis
Tinea Favosa

Favus
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01136 ATF7 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01137 ATF7IP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ATF7 MGD MGI:2443472
Rattus norvegicus ATF7 RGD RGD:1304940
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