2. Gene
  3. JUND - JunD proto-oncogene, AP-1 transcription factor subunit Gene

JUND - JunD proto-oncogene, AP-1 transcription factor subunit Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：JunD 原癌基因，AP-1 转录因子亚基

种属: Homo sapiens

同用名: AP-1

基因 ID: 3727 | 基因类型: protein coding

关于 JUND

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,279,694-18,281,622 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 2 paralogues.

功能概要

由这种无内含子基因编码的蛋白质是 JUN 家族的成员，也是 AP1 转录因子复合物的功能成分。这种蛋白质已被提议用于保护细胞免受 p53 依赖性衰老和细胞凋亡。替代翻译起始位点的使用会导致产生不同的异构体 (PMID:12105216) 。[RefSeq 提供，2013 年 11 月]

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and Apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

JUND 基因产物(2)

mRNA Protein Name
NM_001286968.2 NP_001273897.1 transcription factor JunD isoform deltaJunD
NM_005354.6 NP_005345.3 transcription factor JunD isoform JunD-FL
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
23382074 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9989505 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
1903194 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22327296 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10508860 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IPI
IPI: 通过物理相互作用推断
20102225 GOA
part of transcription factor AP-1 complex IDA
IDA: 通过直接分析推断
10508860 GOA
part of transcription repressor complex IPI
IPI: 通过物理相互作用推断
22327296 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

JUND 蛋白结构

Jun

Jun: Jun-like transcription factor (1 - 257)

bZIP_1

bZIP_1: bZIP transcription factor (266 - 328)

  • 0
  • 100
  • 200
  • 300
  • 347 a.a.
蛋白主名 其他名称

transcription factor JunD

activator protein 1

JUND 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra JUND P17535 BATF3 Homo sapiens Q9NR55
Peptide Array
20102225
Intra JUND P17535 ATF2 Homo sapiens P15336
Peptide Array
20102225
Intra JUND P17535 ACTR3 Homo sapiens P61158
Display Tech
20195357
Intra JUND P17535 FOSL2 Homo sapiens P15408
Peptide Array
20102225
Intra JUND P17535 MDM2 Homo sapiens Q00987
TAP
20195357
Intra JUND P17535 ATF3 Homo sapiens P18847
Peptide Array
20102225
Intra JUND P17535 MAPK10 Homo sapiens P53779
Protein Kinase Assay
22327296
Intra JUND P17535 MAPK10 Homo sapiens P53779
Pull Down
22327296
Intra JUND P17535 BATF Homo sapiens Q16520
Peptide Array
20102225
Intra JUND P17535 ATF7 Homo sapiens P17544
Peptide Array
20102225
Intra JUND P17535 FOS Homo sapiens P01100
Display Tech
20195357
Intra JUND P17535 FOS Homo sapiens P01100
TAP
20195357
Intra JUND P17535 FOS Homo sapiens P01100
Peptide Array
20102225
Intra JUND P17535 MEN1 Homo sapiens O00255-2
Pull Down
22327296
Cross JUND P17535 MDV005 Gallid herpesvirus 2 Q9DGW5
Peptide Array
20102225
Cross JUND P17535 HBZ Human T-cell leukemia virus 1 P0C746
Peptide Array
20102225
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1

MEN1

Wermer Syndrome

Multiple Endocrine Neoplasia 1

Multiple Endocrine Neoplasia, Type 1

Men I

Endocrine Adenomatosis, Multiple

Mea I

Men Type I

Wermer'S Syndrome

Men1 Syndrome

Multiple Endocrine Adenomatosis

Endocrine Adenomatosis Multiple

Men 1

Familial Multiple Endocrine Neoplasia Type I

Neoplasia, Endocrine, Multiple, Type 1

Multiple Endocrine Neoplasia
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Adult T-Cell Leukemia/Lymphoma

Adult T-Cell Leukemia

Atll

Adult T-Cell Leukaemia

Adult T-Cell Leukaemia/Lymphoma

Adult T-Cell Lymphoma

T Cell Leukemia Lymphoma Adult

Leukemia-Lymphoma, Adult T-Cell

Leukemia, T-Cell

Adult T-Cell Lymphoma/Leukemia
T-Cell Adult Acute Lymphocytic Leukemia

Acute Adult T-Cell Leukemia-Lymphoma

Adult Precursor T Lymphoblastic Leukemia

Atll

T-Cell Adult Acute Lymphoblastic Leukemia
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07060 JUND Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus JUND RGD RGD:2945
Felis catus JUND VGNC VGNC:102618
Canis familiaris JUND VGNC VGNC:42199
Mus musculus JUND MGD MGI:96648
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