1. Gene
  2. BATF - basic leucine zipper ATF-like transcription factor Gene

BATF - basic leucine zipper ATF-like transcription factor Gene

中文名称:碱性亮氨酸拉链 ATF 样转录因子

种属: Homo sapiens

同用名: SFA2; B-ATF; BATF1; SFA-2

基因 ID: 10538 | 基因类型: protein coding

关于 BATF

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:75,522,469-75,546,992 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 8 paralogues. Broad expression in lymph node (RPKM 11.0), appendix (RPKM 9.8) and 14 other tissues.

功能概要

该基因编码的蛋白是核碱性亮氨酸拉链蛋白,属于转录因子 AP-1/ATF 超家族。这种蛋白质的亮氨酸拉链介导与 Jun 蛋白质家族成员的二聚化。这种蛋白质被认为是 AP-1/ATF 转录事件的负调节因子。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]

BATF 基因产物(1)

mRNA Protein Name
NM_006399.5 NP_006390.1 basic leucine zipper transcriptional factor ATF-like
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
8954125 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IPI
IPI: 通过物理相互作用推断
20102225 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BATF 蛋白结构

bZIP_1

bZIP_1: bZIP transcription factor (27 - 83)

  • 0
  • 100
  • 125 a.a.
蛋白主名 其他名称

basic leucine zipper transcriptional factor ATF-like

B-cell-activating transcription factor

BATF 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra BATF Q16520 ATF2 Homo sapiens P15336
FRET
23661758
Intra BATF Q16520 CEBPA Homo sapiens P49715
Peptide Array
20102225
Intra BATF Q16520 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
Intra BATF Q16520 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
Intra BATF Q16520 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
Intra BATF Q16520 JUND Homo sapiens P17535
Peptide Array
20102225
Intra BATF Q16520 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra BATF Q16520 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra BATF Q16520 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra BATF Q16520 GOPC Homo sapiens Q9HD26
Y2H Array
25416956
Intra BATF Q16520 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra BATF Q16520 GSN Homo sapiens P06396
Y2H Array
32814053
Intra BATF Q16520 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra BATF Q16520 DBP Homo sapiens Q10586
FRET
23661758
Intra BATF Q16520 ATF4 Homo sapiens P18848
Peptide Array
20102225
Intra BATF Q16520 ATF4 Homo sapiens P18848
FRET
23661758
Intra BATF Q16520 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra BATF Q16520 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra BATF Q16520 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra BATF Q16520 ATF3 Homo sapiens P18847
FRET
23661758
Intra BATF Q16520 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra BATF Q16520 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra BATF Q16520 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra BATF Q16520 GARS1 Homo sapiens P41250
Y2H Pooling
32814053
Intra BATF Q16520 GARS1 Homo sapiens P41250
Validated Y2H
32814053
Intra BATF Q16520 GARS1 Homo sapiens P41250
Y2H Array
32814053
Intra BATF Q16520 CEBPG Homo sapiens P53567
FRET
23661758
Intra BATF Q16520 CEBPG Homo sapiens P53567
Peptide Array
20102225
Intra BATF Q16520 DDIT3 Homo sapiens P35638
Validated Y2H
27107012
Intra BATF Q16520 DDIT3 Homo sapiens P35638
Peptide Array
20102225
Intra BATF Q16520 DDIT3 Homo sapiens P35638
BFG-2H
27107012
Intra BATF Q16520 DDIT3 Homo sapiens P35638
FRET
23661758
Intra BATF Q16520 JUNB Homo sapiens P17275
Y2H Array
18692475
Intra BATF Q16520 JUNB Homo sapiens P17275
Lumier
37398436
Intra BATF Q16520 JUNB Homo sapiens P17275
Peptide Array
20102225
Intra BATF Q16520 JUNB Homo sapiens P17275
BRET
37398436
Intra BATF Q16520 JUNB Homo sapiens P17275
Validated Y2H
25416956
Intra BATF Q16520 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra BATF Q16520 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra BATF Q16520 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra BATF Q16520 JUN Homo sapiens P05412
Peptide Array
20102225
Intra BATF Q16520 JUN Homo sapiens P05412
FRET
23661758
Intra BATF Q16520 CEBPB Homo sapiens P17676
Peptide Array
20102225
Intra BATF Q16520 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Intra BATF Q16520 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Intra BATF Q16520 PEX1 Homo sapiens O43933
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Prion Disease

Spongiform Encephalopathy

Transmissible Spongiform Encephalopathies

Prion Diseases

Prion Disease Pathway

Transmissible Spongiform Encephalopathy

Prion Induced Disorder

Prion Protein Disease

Inherited Human Transmissible Spongiform Encephalopathies

Prion Protein Diseases

Prion-Associated Disorders

Prion-Induced Disorders

Transmissible Dementias

Tses

Human Prion Disease

Tse

Encephalopathy, Transmissible Spongiform

Prion Disease, Susceptibility To

Spongiform Encephalopathies

Human Transmissible Spongiform Encephalopathies, Inherited

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BATF VGNC VGNC:70229
Rattus norvegicus BATF RGD RGD:1304923
Bos taurus BATF VGNC VGNC:26425
Felis catus BATF VGNC VGNC:81030
Canis familiaris BATF VGNC VGNC:38385
Mus musculus BATF MGD MGI:1859147