DBP - D-box binding PAR bZIP transcription factor Gene

中文名称：D-box 结合 PAR bZIP 转录因子

种属: Homo sapiens

同用名: DABP; taxREB302

基因 ID: 1628 | 基因类型: protein coding

关于 DBP

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,630,030-48,637,379 (from NCBI)

This gene has 5 transcripts (splice variants), 251 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 6.3), spleen (RPKM 6.2) and 25 other tissues.

功能概要

由该基因编码的蛋白质是 PAR bZIP 转录因子家族的成员，并与白蛋白、CYP2A4 和 CYP2A5 等多个基因启动子中的特定序列结合。编码的蛋白质可以作为同二聚体或异二聚体与 DNA 结合，并参与某些昼夜节律基因的调节。[RefSeq 提供，2014 年 7 月]

The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]

DBP 基因产物(1)

mRNA	Protein	Name
NM_001352.5	NP_001343.2	D site-binding protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	20093779	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	20093779	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21988832	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	20093779	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA polymerase II transcription regulator complex	IPI IPI: 通过物理相互作用推断	23661758	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DBP 蛋白结构

bZIP_2

0
100
200
300
325 a.a.

蛋白主名

其他名称

D site-binding protein

D site of albumin promoter (albumin D-box) binding protein

DBP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	DBP	Q10586	BATF3	Homo sapiens	Q9NR55	FRET	23661758
Intra	DBP	Q10586	HLF	Homo sapiens	Q16534	FRET	23661758
Intra	DBP	Q10586	DDIT3	Homo sapiens	P35638	Y2H	21988832
Intra	DBP	Q10586	DDIT3	Homo sapiens	P35638	FRET	23661758
Intra	DBP	Q10586	BATF	Homo sapiens	Q16520	FRET	23661758

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hemophilia B

Christmas Disease	Factor Ix Deficiency
F9 Deficiency	HEMB
Plasma Thromboplastin Component Deficiency	Congenital Factor Ix Deficiency
Mild Hemophilia B	Severe Hemophilia B
Congenital Factor Ix Disorder	Deficiency, Functional Factor Ix
Hem B	Mild Congenital F9 Deficiency
Mild Congenital Factor Ix Deficiency	Moderate Hemophilia B
Moderate Congenital F9 Deficiency	Moderate Congenital Factor Ix Deficiency
Severe Congenital F9 Deficiency	Severe Congenital Factor Ix Deficiency
Bleeding Disorder In Hemophilia B Carriers	Congenital F9 Deficiency
Recessive X-Linked Hemophilia B

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N7143	Monobutyl phthalate		99.85%	否
HY-N7143S	Monobutyl phthalate-d4		99.34%	否
HY-133630	1-Bromo-1,1-dichloroacetone		/	否
HY-133631	Chloronitromethane		≥98.0%	否
HY-133626	1,1-Dibromo-3,3-dichloroacetone		/	否
HY-133627	1,3-Dibromo-1,3-dichloroacetone		/	否
HY-133628	1,1,3-Tribromo-3-chloroacetone		/	否
HY-133633	Bromodichloronitromethane		/	否
HY-133635	Tribromonitromethane		/	否
HY-133636	Bromochloronitromethane		/	否
HY-133656	(Z)-2-Bromo-3-methyl-2-butenedioic acid		/	否
HY-133657	Bromoiodoacetic acid		/	否
HY-133659	Diiodoacetic acid		/	否
HY-133664	Dibromochloroacetamide		/	否
HY-133665	2,2-Dibromoacetamide		/	否
HY-133666	Diiodoacetamide		/	否
HY-RS03552	DBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-133625	1,1-Dibromo-3-chloroacetone		/	否
HY-133629	1,1,1,3-Tetrachloroacetone		/	否
HY-133634	Dibromochloronitromethane		/	否
HY-133655	(E)-2,3-Dibromo-2-butenedioic acid		/	否
HY-W243879	Tetraphenyldibenzoperiflanthene		/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	DBP	VGNC	VGNC:39785
Macaca mulatta	DBP	VGNC	VGNC:71743
Bos taurus	DBP	VGNC	VGNC:27894
Rattus norvegicus	DBP	RGD	RGD:2491
Mus musculus	DBP	MGD	MGI:94866
Others	DBP	NCBI

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