HLF - HLF transcription factor, PAR bZIP family member Gene

中文名称：HLF 转录因子，PAR bZIP 家族成员

种属: Homo sapiens

基因 ID: 3131 | 基因类型: protein coding

关于 HLF

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:55,264,960-55,325,187 (from NCBI)

This gene has 11 transcripts (splice variants), 262 orthologues, 2 paralogues and is associated with 62 phenotypes. Broad expression in liver (RPKM 22.6), brain (RPKM 22.4) and 18 other tissues.

功能概要

该基因编码富含脯氨酸和酸性 (PAR) 蛋白家族的成员，是 bZIP 转录因子的一个子集。编码的蛋白质与其他 PAR 家族成员形成同二聚体或异二聚体，并结合序列特异性启动子元件以激活转录。将该基因的一部分与 E2A 基因融合的染色体易位会导致一部分儿童 B 系急性淋巴细胞白血病。已经描述了选择性剪接的转录本变体，但尚未确定它们的生物学有效性。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with Other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

HLF 基因产物(2)

mRNA	Protein	Name
NM_001330375.2	NP_001317304.1	hepatic leukemia factor isoform 2
NM_002126.5	NP_002117.1	hepatic leukemia factor isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	8065331	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	8065331	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20102225	GOA
enables sequence-specific DNA binding	IMP IMP: 通过突变表型推断	8065331	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	8065331	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA polymerase II transcription regulator complex	IPI IPI: 通过物理相互作用推断	23661758	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HLF 蛋白结构

bZIP_2

0
100
200
295 a.a.

蛋白主名

其他名称

hepatic leukemia factor

E2A-HLF fusion transcript protein

HLF 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HLF	Q16534	BATF3	Homo sapiens	Q9NR55	Peptide Array	20102225
种属内	HLF	Q16534	BATF3	Homo sapiens	Q9NR55	FRET	23661758
种属内	HLF	Q16534	DBP	Homo sapiens	Q10586	FRET	23661758
种属内	HLF	Q16534	DBP	Homo sapiens	Q10586	Y2H	21988832
种属内	HLF	Q16534	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
种属内	HLF	Q16534	DDIT3	Homo sapiens	P35638	FRET	23661758
种属内	HLF	Q16534	BATF	Homo sapiens	Q16520	FRET	23661758
种属内	HLF	Q16534	BATF	Homo sapiens	Q16520	Peptide Array	20102225

种属间: 跨种属相互作用 种属内: 同种属相互作用

HLF 抗体

目录号	产品名	应用	反应物种
HY-P83245	HLF Antibody (YA2990)	WB	Human

关联疾病

疾病名称

别名

B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Partial Motor Epilepsy

Epilepsy, Partial, Motor	Epilepsy, Focal Motor
Focal Motor Seizure

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Erythrocytosis, Familial, 1

ECYT1	Pfcp
Primary Familial And Congenital Polycythemia	Familial Erythrocytosis 1
Familial Erythrocytosis	Polycythemia, Primary Familial And Congenital
Autosomal Dominant Benign Erythrocytosis	Familial Erythrocytosis Type 1
Congenital Erythrocytosis Due To Erythropoietin Receptor Mutation	Congenital Polycythemia Due To Erythropoietin Receptor Mutation
Primary Congenital Erythrocytosis	Primary Familial Polycythemia
Erythrocytosis, Autosomal Dominant Benign	Erythrocytosis, Somatic
Autosomal Dominant Familial Erythrocytosis-1	Erythrocytosis Autosomal Dominant Benign
Familial Primary Polycythemia	Familial Erythrocytosis, 1
Erythrocytosis, Familial, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-106228	HLF1-11	Inhibitor	99.91%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-144075	JAK-IN-19	Inhibitor	/	否
HY-146724	Dot1L-IN-7	Inhibitor	/	否
HY-147946	PDE1-IN-4	Inhibitor	/	否
HY-RS06219	HLF Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	HLF	MGD	MGI:96108
Bos taurus	HLF	VGNC	VGNC:50275
Rattus norvegicus	HLF	RGD	RGD:1582828
Macaca mulatta	HLF	VGNC	VGNC:73478
Canis familiaris	HLF	VGNC	VGNC:49094
Felis catus	HLF	VGNC	VGNC:67589

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