1. Anti-infection Metabolic Enzyme/Protease Apoptosis
  2. Fungal Bacterial Glutathione Peroxidase
  3. HLF1-11

HLF1-11,一种人乳铁蛋白衍生肽,是一种广谱抗菌剂。HLF1-11 抑制 MPO (human) 的活性。HLF1-11 还使 GM-CSF 驱动的单核细胞向巨噬细胞分化,并增强其免疫反应。

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Custom Peptide Synthesis

HLF1-11 Chemical Structure

HLF1-11 Chemical Structure

CAS No. : 183623-03-2

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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10 mg ¥1000
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25 mg ¥2000
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. HLF1-11 inhibits human MPO activity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses[1][2].

体外研究
(In Vitro)

hLF1-11 (1, 10, and 100 μg/mL) directs differentiation of monocytes toward a macrophage subset during granulocyte-macrophage colony-stimulating factor (GM-CSF)-driven monocytes differentiation[2].
hLF1-11 (0.5-250 μg/mL) inhibits human MPO activity[3].
hLF1-11 (100 μg/mL, 90 min) inhibits ROS induction induced by LPS in monocytes[3].
hLF1-11 (8-34 μΜ, 2 h) is active against fluconazole-resistant C. albicans[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

hLF1-11 (20 mg/kg, injected into the debrided tibial cavity) shows ability against MRSA osteomyelitis in rabbits[4].
hLF1-11 (40 μg/kg, i.v.) is active against C. albicans-infected mice[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rabbits inoculated with CFU MRSA[4]
Dosage: 20 mg/kg
Administration: Injected into the debrided tibial cavity
Result: Reduced bacterial load compared to controls, and reduced the radiological and histopathological score.
Animal Model: Neutropenic mice challenged i.v. with C. albicans
Dosage: 40 μg/kg
Administration: Intravenous injection (i.v)
Result: Reduced serum TNFα and IL-6 in infected mice.
Clinical Trial
分子量

1374.58

Formula

C56H95N25O14S

CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

GRRRRSVQWCA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
细胞实验: 

H2O 中的溶解度 : 100 mg/mL (72.75 mM; 超声助溶)

DMSO 中的溶解度 : ≥ 100 mg/mL (72.75 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7275 mL 3.6375 mL 7.2750 mL
5 mM 0.1455 mL 0.7275 mL 1.4550 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.91%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.7275 mL 3.6375 mL 7.2749 mL 18.1874 mL
5 mM 0.1455 mL 0.7275 mL 1.4550 mL 3.6375 mL
10 mM 0.0727 mL 0.3637 mL 0.7275 mL 1.8187 mL
15 mM 0.0485 mL 0.2425 mL 0.4850 mL 1.2125 mL
20 mM 0.0364 mL 0.1819 mL 0.3637 mL 0.9094 mL
25 mM 0.0291 mL 0.1455 mL 0.2910 mL 0.7275 mL
30 mM 0.0242 mL 0.1212 mL 0.2425 mL 0.6062 mL
40 mM 0.0182 mL 0.0909 mL 0.1819 mL 0.4547 mL
50 mM 0.0145 mL 0.0727 mL 0.1455 mL 0.3637 mL
60 mM 0.0121 mL 0.0606 mL 0.1212 mL 0.3031 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
HLF1-11
目录号:
HY-106228
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