1. Gene
  2. BATF3 - basic leucine zipper ATF-like transcription factor 3 Gene

BATF3 - basic leucine zipper ATF-like transcription factor 3 Gene

中文名称:碱性亮氨酸拉链 ATF 样转录因子 3

种属: Homo sapiens

同用名: JDP1; SNFT; JUNDM1

基因 ID: 55509 | 基因类型: protein coding

关于 BATF3

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,686,417-212,699,840 (from NCBI)

This gene has 3 transcripts (splice variants), 173 orthologues and 8 paralogues. Broad expression in spleen (RPKM 2.9), appendix (RPKM 1.9) and 20 other tissues.

功能概要

该基因编码基本亮氨酸拉链蛋白家族的成员。当与 JUN 异二聚化时,编码的蛋白质起到转录抑制因子的作用。该蛋白质可能在抑制白细胞介素 2 和基质金属蛋白酶 1 转录中发挥作用。[RefSeq 提供,2009 年 2 月]

This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]

BATF3 基因产物(1)

mRNA Protein Name
NM_018664.3 NP_061134.1 basic leucine zipper transcriptional factor ATF-like 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
15467742 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15467742 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20102225 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15467742 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IPI
IPI: 通过物理相互作用推断
20102225 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BATF3 蛋白结构

bZIP_1

bZIP_1: bZIP transcription factor (33 - 93)

  • 0
  • 100
  • 127 a.a.
蛋白主名 其他名称

basic leucine zipper transcriptional factor ATF-like 3

21 kDa small nuclear factor isolated from T-cells

BATF3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra BATF3 Q9NR55 DDIT3 Homo sapiens P35638-2
Y2H Array
25416956
Intra BATF3 Q9NR55 CREB5 Homo sapiens Q02930-3
Y2H Prey Pooling
32296183
Intra BATF3 Q9NR55 CREB5 Homo sapiens Q02930-3
Y2H Array
32296183
Intra BATF3 Q9NR55 ATF2 Homo sapiens P15336
Anti Tag CoIP
33961781
Intra BATF3 Q9NR55 ATF2 Homo sapiens P15336
Anti Tag CoIP
28514442
Intra BATF3 Q9NR55 ATF2 Homo sapiens P15336
FRET
23661758
Intra BATF3 Q9NR55 GPATCH2L Homo sapiens Q9NWQ4-1
Validated Y2H
32296183
Intra BATF3 Q9NR55 BACH2 Homo sapiens Q9BYV9
Y2H Array
32296183
Intra BATF3 Q9NR55 BACH2 Homo sapiens Q9BYV9
FRET
23661758
Intra BATF3 Q9NR55 BACH2 Homo sapiens Q9BYV9
Anti Tag CoIP
33961781
Intra BATF3 Q9NR55 BACH2 Homo sapiens Q9BYV9
Y2H Prey Pooling
32296183
Intra BATF3 Q9NR55 BACH2 Homo sapiens Q9BYV9
Anti Tag CoIP
28514442
Intra BATF3 Q9NR55 JUND Homo sapiens P17535
Anti Tag CoIP
33961781
Intra BATF3 Q9NR55 JUND Homo sapiens P17535
Anti Tag CoIP
28514442
Intra BATF3 Q9NR55 JUND Homo sapiens P17535
Peptide Array
20102225
Intra BATF3 Q9NR55 DBP Homo sapiens Q10586
FRET
23661758
Intra BATF3 Q9NR55 ATF4 Homo sapiens P18848
FRET
23661758
Intra BATF3 Q9NR55 ATF3 Homo sapiens P18847
Peptide Array
20102225
Intra BATF3 Q9NR55 ATF3 Homo sapiens P18847
FRET
23661758
Intra BATF3 Q9NR55 MAFG Homo sapiens O15525
FRET
23661758
Intra BATF3 Q9NR55 MAFF Homo sapiens Q9ULX9
FRET
23661758
Intra BATF3 Q9NR55 CEBPG Homo sapiens P53567
FRET
23661758
Intra BATF3 Q9NR55 CEBPG Homo sapiens P53567
Peptide Array
20102225
Intra BATF3 Q9NR55 DDIT3 Homo sapiens P35638
FRET
23661758
Intra BATF3 Q9NR55 DDIT3 Homo sapiens P35638
Y2H Array
32296183
Intra BATF3 Q9NR55 DDIT3 Homo sapiens P35638
Peptide Array
20102225
Intra BATF3 Q9NR55 DDIT3 Homo sapiens P35638
Y2H Prey Pooling
32296183
Intra BATF3 Q9NR55 FOSL1 Homo sapiens P15407
Y2H Array
32296183
Intra BATF3 Q9NR55 FOSL1 Homo sapiens P15407
Y2H Prey Pooling
32296183
Intra BATF3 Q9NR55 JUNB Homo sapiens P17275
Anti Tag CoIP
33961781
Intra BATF3 Q9NR55 JUNB Homo sapiens P17275
Anti Tag CoIP
28514442
Intra BATF3 Q9NR55 JUNB Homo sapiens P17275
Peptide Array
20102225
Intra BATF3 Q9NR55 JUN Homo sapiens P05412
Peptide Array
20102225
Intra BATF3 Q9NR55 JUN Homo sapiens P05412
FRET
23661758
Intra BATF3 Q9NR55 JUN Homo sapiens P05412
Anti Tag CoIP
33961781
Intra BATF3 Q9NR55 JUN Homo sapiens P05412
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dendritic Cell Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris BATF3 VGNC VGNC:38387
Bos taurus BATF3 VGNC VGNC:26427
Mus musculus BATF3 MGD MGI:1925491
Felis catus BATF3 VGNC VGNC:107843
Macaca mulatta BATF3 VGNC VGNC:70143
Rattus norvegicus BATF3 RGD RGD:620501