2. Gene
  3. MAFG - MAF bZIP transcription factor G Gene

MAFG - MAF bZIP transcription factor G Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MAF bZIP 转录因子 G

种属: Homo sapiens

同用名: hMAF

基因 ID: 4097 | 基因类型: protein coding

关于 MAFG

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,918,270-81,931,244 (from NCBI)

This gene has 3 transcripts (splice variants), 262 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 12.5), brain (RPKM 8.7) and 25 other tissues.

功能概要

珠蛋白基因表达通过位于 alpha 和 beta 基因簇上游许多 kb 的增强子样基因座控制区域中的核因子红细胞 2 (NFE2) 元件进行调节 (由 Blank 等人总结，1997 [PubMed 9166829]) 。 NFE2 DNA 结合活性由含有普遍存在的小 Maf 蛋白 (MafF，MIM 604877；MafG；或 MafK，MIM 600197) 和组织限制蛋白 p45 NFE2 (MIM 601490) 的异二聚体组成。两个亚基都是碱性亮氨酸拉链 (bZIP) 蛋白激活蛋白 1 样超家族的成员 (参见 MIM 165160) 。[OMIM 提供，2010 年 3 月]

Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

MAFG 基因产物(2)

mRNA Protein Name
NM_002359.4 NP_002350.1 transcription factor MafG
NM_032711.4 NP_116100.2 transcription factor MafG
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20102225 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8932385 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IPI
IPI: 通过物理相互作用推断
23661758 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAFG 蛋白结构

bZIP_Maf

bZIP_Maf: bZIP Maf transcription factor (24 - 115)

  • 0
  • 100
  • 162 a.a.
蛋白主名 其他名称

transcription factor MafG

basic leucine zipper transcription factor MafG

MAFG 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MAFG O15525 BATF3 Homo sapiens Q9NR55
FRET
23661758
Intra MAFG O15525 NFE2L3 Homo sapiens Q9Y4A8
FRET
23661758
Intra MAFG O15525 NFE2L1 Homo sapiens Q14494-2
SLC
31467278
Intra MAFG O15525 BACH1 Homo sapiens O14867
Peptide Array
20102225
Intra MAFG O15525 BACH1 Homo sapiens O14867
FRET
23661758
Intra MAFG O15525 BACH2 Homo sapiens Q9BYV9
Y2H Prey Pooling
32296183
Intra MAFG O15525 BACH2 Homo sapiens Q9BYV9
Validated Y2H
32296183
Intra MAFG O15525 BACH2 Homo sapiens Q9BYV9
FRET
23661758
Intra MAFG O15525 BACH2 Homo sapiens Q9BYV9
Y2H Array
32296183
Intra MAFG O15525 NFE2L2 Homo sapiens Q16236
Y2H Prey Pooling
32296183
Intra MAFG O15525 NFE2L2 Homo sapiens Q16236
Complementation
32296183
Intra MAFG O15525 NFE2L2 Homo sapiens Q16236
Validated Y2H
32296183
Intra MAFG O15525 NFE2L2 Homo sapiens Q16236
MAPPIT
25416956
Intra MAFG O15525 NFE2L2 Homo sapiens Q16236
FRET
23661758
Intra MAFG O15525 NFE2L2 Homo sapiens Q16236
Y2H Array
32296183
Intra MAFG O15525 NFE2L2 Homo sapiens Q16236
Y2H Pooling
18692475
Intra MAFG O15525 NFE2L2 Homo sapiens Q16236
Y2H
21988832
Intra MAFG O15525 NFE2L1 Homo sapiens Q14494
FRET
23661758
Intra MAFG O15525 NFIL3 Homo sapiens Q16649
FRET
23661758
Intra MAFG O15525 MAFF Homo sapiens Q9ULX9
FRET
23661758
Cross MAFG O15525 HBZ Human T-cell leukemia virus 1 P0C746
Peptide Array
20102225
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Homocystinuria-Megaloblastic Anemia Cble Type

Functional Methionine Synthase Deficiency Type Cble

Hmae

Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism Cble Complementation Type

Methylcobalamin Deficiency, Cble Type

Vitamin B12-Responsive Homocystinuria, Cble Type
Fibrosarcoma

Neoplasms, Fibrous Tissue

Fibrocytic Tumor

Fibrosarcoma Of Soft Tissue

Fibrous Tissue Neoplasm
Clear Cell Acanthoma

Acanthoma

Pale Acanthoma

Acanthoma, Clear Cell
Ayme-Gripp Syndrome

AYGRP

Cataracts, Congenital, With Sensorineural Deafness, Down Syndrome-Like Facial Appearance, Short Stature, And Mental Retardation

Aymé-Gripp Syndrome

Fine-Lubinsky Syndrome

Brachycephaly-Deafness-Cataract-Intellectual Disability Syndrome

Brachycephaly-Hearing Loss-Cataract-Intellectual Disability Syndrome
Anemia, Congenital Dyserythropoietic, Type Ia

Congenital Dyserythropoietic Anemia Type I

Cda I

CDAN1A

Congenital Dyserythropoietic Anemia Type 1

Congenital Dyserythropoietic Anemia Type Ia

Congenital Dyserythropoietic Anemia, Type I

Anemia, Congenital Dyserythropoietic, Type I

Cda Type 1

Cda Type I

Cda Ia

Dyserythropoietic Anemia, Congenital Type 1

Anemia, Congenital Dyserythropoietic, Type 1a

Dyserythropoietic Anemia, Congenital, Type Ia

Cda, Type Ia

Congenital Dyserythropoietic Anaemia Type 1

Congenital Dyserythropoietic Anaemia Type I

Anemia, Dyserythropoietic, Congenital Type 1

Type I Congenital Dyserythropoietic Anemia

Anemia, Congenital Dyserythropoietic, 1a

Anemia, Dyserythropoietic, Congenital, Type Ia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07961 MAFG Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MAFG VGNC VGNC:42921
Bos taurus MAFG VGNC VGNC:31141
Felis catus MAFG VGNC VGNC:99208
Mus musculus MAFG MGD MGI:96911
Rattus norvegicus MAFG RGD RGD:619953
Macaca mulatta MAFG VGNC VGNC:74474
Macaca fascicularis MAFG NCBI NCBI:102141646
Others MAFG NCBI
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