MAFF - MAF bZIP transcription factor F Gene

中文名称：MAF bZIP 转录因子 F

种属: Homo sapiens

同用名: U-MAF; hMafF

基因 ID: 23764 | 基因类型: protein coding

关于 MAFF

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,201,994-38,216,511 (from NCBI)

This gene has 8 transcripts (splice variants), 190 orthologues and 6 paralogues. Ubiquitous expression in gall bladder (RPKM 22.1), fat (RPKM 18.9) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种基本的亮氨酸拉链 (bZIP) 转录因子，缺少反式激活域。已知结合催产素受体 (OTR) 基因启动子中的 US-2 DNA 元件，并且很可能与其他含有亮氨酸拉链的蛋白质异源二聚化，以增强足月妊娠期间 OTR 基因的表达。编码的蛋白质也可以形成同型二聚体，并且由于它缺少反式激活结构域，同型二聚体可能充当转录抑制因子。该基因也可能参与细胞应激反应。已发现该基因编码两种不同亚型的多个转录变体。[RefSeq 提供，2009 年 6 月]

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the Oxytocin Receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

MAFF 基因产物(4)

mRNA	Protein	Name
NM_001161572.2	NP_001155044.1	transcription factor MafF isoform a
NM_001161573.1	NP_001155045.1	transcription factor MafF isoform a
NM_001161574.2	NP_001155046.1	transcription factor MafF isoform b
NM_012323.4	NP_036455.1	transcription factor MafF isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	12490281	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	8932385	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12490281	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA polymerase II transcription regulator complex	IPI IPI: 通过物理相互作用推断	23661758	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAFF 蛋白结构

bZIP_Maf

0
100
164 a.a.

蛋白主名

其他名称

transcription factor MafF

v-maf avian musculoaponeurotic fibrosarcoma oncogene family protein F

MAFF 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MAFF	Q9ULX9	BATF3	Homo sapiens	Q9NR55	FRET	23661758
Intra	MAFF	Q9ULX9	NFE2L3	Homo sapiens	Q9Y4A8	FRET	23661758
Intra	MAFF	Q9ULX9	NFE2L3	Homo sapiens	Q9Y4A8	Anti Tag CoIP	33961781
Intra	MAFF	Q9ULX9	NFE2L3	Homo sapiens	Q9Y4A8	Anti Tag CoIP	28514442
Intra	MAFF	Q9ULX9	BACH1	Homo sapiens	O14867	FRET	23661758
Intra	MAFF	Q9ULX9	BACH2	Homo sapiens	Q9BYV9	Anti Tag CoIP	33961781
Intra	MAFF	Q9ULX9	BACH2	Homo sapiens	Q9BYV9	FRET	23661758
Intra	MAFF	Q9ULX9	BACH2	Homo sapiens	Q9BYV9	Anti Tag CoIP	28514442
Intra	MAFF	Q9ULX9	NFE2L2	Homo sapiens	Q16236	FRET	23661758
Intra	MAFF	Q9ULX9	NFE2L2	Homo sapiens	Q16236	Anti Tag CoIP	33961781
Intra	MAFF	Q9ULX9	NFE2L1	Homo sapiens	Q14494	Anti Tag CoIP	33961781
Intra	MAFF	Q9ULX9	NFE2L1	Homo sapiens	Q14494	FRET	23661758
Intra	MAFF	Q9ULX9	NFIL3	Homo sapiens	Q16649	FRET	23661758
Intra	MAFF	Q9ULX9	ATF3	Homo sapiens	P18847	FRET	23661758
Intra	MAFF	Q9ULX9	MAFG	Homo sapiens	O15525	FRET	23661758
Intra	MAFF	Q9ULX9	BATF2	Homo sapiens	Q8N1L9	FRET	23661758

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy

Autosomal Dominant Adult-Onset Proximal Sma	Autosomal Dominant Late-Onset Spinal Muscular Atrophy, Finkel Type
Finkel Disease	Smafk
Adult-Onset Proximal Spinal Muscular Atrophy, Autosomal Dominant	Autosomal Dominant Adult Proximal Spinal Muscular Atrophy
Finkel Late-Adult Type Sma

Multicentric Carpotarsal Osteolysis Syndrome

Multicentric Carpo-Tarsal Osteolysis With Or Without Nephropathy	MCTO
Osteolysis, Hereditary, Of Carpal Bones With Or Without Nephropathy	Idiopathic Multicentric Osteolysis With Or Without Nephropathy
Autosomal Dominant Multicentric Osteolysis	Hereditary Osteolysis Of Carpal Bones With Or Without Nephropathy
Multicentric Osteolysis, Autosomal Dominant	Multicentric Osteolysis Nephropathy
Osteolysis, Carpotarsal, Multicentric Syndrome	Lytic Lesion

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07960	MAFF Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MAFF	VGNC	VGNC:31140
Macaca mulatta	MAFF	VGNC	VGNC:95357
Mus musculus	MAFF	MGD	MGI:96910
Rattus norvegicus	MAFF	RGD	RGD:1309531
Canis familiaris	MAFF	VGNC	VGNC:49919

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