BATF2 - basic leucine zipper ATF-like transcription factor 2 Gene

中文名称：碱性亮氨酸拉链 ATF 样转录因子 2

种属: Homo sapiens

同用名: SARI

基因 ID: 116071 | 基因类型: protein coding

关于 BATF2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,987,945-64,996,971 (from NCBI)

This gene has 5 transcripts (splice variants), 238 orthologues and 8 paralogues. Broad expression in spleen (RPKM 7.0), appendix (RPKM 4.9) and 23 other tissues.

功能概要

预测可实现 DNA 结合转录因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。预计参与对原生动物的防御反应；髓样树突状细胞分化； RNA 聚合酶 II 对转录的调控。预测是染色质的一部分。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in defense response to protozoan; myeloid dendritic cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

BATF2 基因产物(3)

mRNA	Protein	Name
NM_001300807.2	NP_001287736.1	basic leucine zipper transcriptional factor ATF-like 2 isoform 2
NM_001300808.2	NP_001287737.1	basic leucine zipper transcriptional factor ATF-like 2 isoform 3
NM_138456.4	NP_612465.3	basic leucine zipper transcriptional factor ATF-like 2 isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA polymerase II transcription regulator complex	IPI IPI: 通过物理相互作用推断	23661758	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BATF2 蛋白结构

bZIP_1

0
100
200
274 a.a.

蛋白主名

其他名称

basic leucine zipper transcriptional factor ATF-like 2

B-ATF-2

BATF2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	BATF2	Q8N1L9	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	BATF2	Q8N1L9	YTHDF1	Homo sapiens	Q9BYJ9	Validated Y2H	32296183
Intra	BATF2	Q8N1L9	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
Intra	BATF2	Q8N1L9	GPSM3	Homo sapiens	Q9Y4H4	Validated Y2H	32296183
Intra	BATF2	Q8N1L9	PPP1R16A	Homo sapiens	Q96I34	Validated Y2H	32296183
Intra	BATF2	Q8N1L9	MAFF	Homo sapiens	Q9ULX9	FRET	23661758
Intra	BATF2	Q8N1L9	DAZAP2	Homo sapiens	Q15038	Y2H Array	19060904
Intra	BATF2	Q8N1L9	DAZAP2	Homo sapiens	Q15038	Y2H Pooling	19060904
Intra	BATF2	Q8N1L9	CEBPG	Homo sapiens	P53567	FRET	23661758
Intra	BATF2	Q8N1L9	DDIT3	Homo sapiens	P35638	FRET	23661758
Intra	BATF2	Q8N1L9	JUNB	Homo sapiens	P17275	Anti Tag CoIP	21988832
Intra	BATF2	Q8N1L9	JUN	Homo sapiens	P05412	FRET	23661758

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01372	BATF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	BATF2	VGNC	VGNC:38386
Felis catus	BATF2	VGNC	VGNC:60074
Macaca mulatta	BATF2	VGNC	VGNC:70127
Bos taurus	BATF2	VGNC	VGNC:26426
Rattus norvegicus	BATF2	RGD	RGD:1311481
Mus musculus	BATF2	MGD	MGI:1921731

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