2. Gene
  3. YTHDF1 - YTH N6-methyladenosine RNA binding protein 1 Gene

YTHDF1 - YTH N6-methyladenosine RNA binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：YTH N6-甲基腺苷 RNA 结合蛋白 1

种属: Homo sapiens

同用名: DF1; C20orf21

基因 ID: 54915 | 基因类型: protein coding

关于 YTHDF1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,195,429-63,216,131 (from NCBI)

This gene has 2 transcripts (splice variants), 262 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 18.6), bone marrow (RPKM 15.2) and 25 other tissues.

功能概要

启用含 N6-甲基腺苷的 RNA 结合活性和核糖体结合活性。参与 mRNA 不稳定；翻译起始的正调控；和应力颗粒组装。位于 P 体和细胞质应激颗粒中。 [由基因组资源联盟提供，2022 年 4 月]

Enables N6-methyladenosine-containing RNA binding activity and ribosome binding activity. Involved in mRNA destabilization; positive regulation of translational initiation; and stress granule assembly. Located in P-body and cytoplasmic stress granule. [provided by Alliance of Genome Resources, Apr 2022]

YTHDF1 基因产物(1)

mRNA Protein Name
NM_017798.4 NP_060268.2 YTH domain-containing family protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: 通过直接分析推断
24284625 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28106072 GOA
enables ribosome binding IDA
IDA: 通过直接分析推断
26046440 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA destabilization IDA
IDA: 通过直接分析推断
32492408 GOA
involved in organelle assembly IDA
IDA: 通过直接分析推断
31292544 GOA
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
28106072 GOA
NOT involved in positive regulation of translational initiation IDA
IDA: 通过直接分析推断
32492408 GOA
involved in positive regulation of translational initiation IDA
IDA: 通过直接分析推断
26046440 GOA
involved in regulation of mRNA stability IDA
IDA: 通过直接分析推断
32492408 GOA
involved in stress granule assembly IDA
IDA: 通过直接分析推断
32451507 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
32492408 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
32492408 GOA
located in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
32451507 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

YTHDF1 蛋白结构

YTH

YTH: YT521-B-like domain (390 - 524)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 559 a.a.
蛋白主名 其他名称

YTH domain-containing family protein 1

DACA-1

YTHDF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra YTHDF1 Q9BYJ9 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 FAM168A Homo sapiens Q92567-2
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 FAM168A Homo sapiens Q92567-2
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 C6orf15 Homo sapiens Q6UXA7
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 C6orf15 Homo sapiens Q6UXA7
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 HSF4 Homo sapiens Q9ULV5-2
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 HSF4 Homo sapiens Q9ULV5-2
Validated Y2H
32296183
Intra YTHDF1 Q9BYJ9 HSF4 Homo sapiens Q9ULV5-2
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 ABHD11 Homo sapiens Q8NFV4-4
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 ABHD11 Homo sapiens Q8NFV4-4
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 PRR32 Homo sapiens B1ATL7
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 PRR32 Homo sapiens B1ATL7
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 VPS37C Homo sapiens A5D8V6
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 VPS37C Homo sapiens A5D8V6
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 YTHDF3 Homo sapiens Q7Z739
Anti Tag CoIP
33961781
Intra YTHDF1 Q9BYJ9 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Intra YTHDF1 Q9BYJ9 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 MSX2 Homo sapiens P35548
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 MSX2 Homo sapiens P35548
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra YTHDF1 Q9BYJ9 HEY1 Homo sapiens Q9Y5J3
Validated Y2H
32296183
Intra YTHDF1 Q9BYJ9 HEY1 Homo sapiens Q9Y5J3
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 HEY1 Homo sapiens Q9Y5J3
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 BATF2 Homo sapiens Q8N1L9
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 BATF2 Homo sapiens Q8N1L9
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 LASP1 Homo sapiens Q14847-2
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 LASP1 Homo sapiens Q14847-2
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ocular Melanoma

Intraocular Melanoma

Uveal Melanoma

Eye Melanoma

Melanoma Of Eye

Melanoma Of The Uvea

Malignant Melanoma Of Eye
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15937 YTHDF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-168610 YTH-IN-1 / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus YTHDF1 VGNC VGNC:67151
Bos taurus YTHDF1 VGNC VGNC:37041
Canis familiaris YTHDF1 VGNC VGNC:48505
Macaca mulatta YTHDF1 VGNC VGNC:78988
Rattus norvegicus YTHDF1 RGD RGD:1308932
Mus musculus YTHDF1 MGD MGI:1917431
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