YTHDF3 - YTH N6-methyladenosine RNA binding protein 3 Gene

中文名称：YTH N6-甲基腺苷 RNA 结合蛋白 3

种属: Homo sapiens

同用名: DF3

基因 ID: 253943 | 基因类型: protein coding

关于 YTHDF3

Cytogenetic location: 8q12.3 Genomic coordinates (GRCh38): 8:63,168,553-63,212,788 (from NCBI)

This gene has 16 transcripts (splice variants), 204 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 27.1), colon (RPKM 15.4) and 25 other tissues.

功能概要

该基因编码 YTH (YT521-B 同源) 域蛋白家族的成员。 YTH 结构域在真核生物中很常见，通常位于蛋白质序列的中间，可能与 RNA 结合。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 4 月]

This gene encodes a member of the YTH (YT521-B homology) domain protein family. The YTH domain is common in eukaryotes, is often found in the middle of the protein sequence, and may function in binding to RNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

YTHDF3 基因产物(7)

mRNA	Protein	Name
NM_001277813.2	NP_001264742.1	YTH domain-containing family protein 3 isoform b
NM_001277814.2	NP_001264743.1	YTH domain-containing family protein 3 isoform b
NM_001277815.2	NP_001264744.1	YTH domain-containing family protein 3 isoform c
NM_001277816.2	NP_001264745.1	YTH domain-containing family protein 3 isoform c
NM_001277817.2	NP_001264746.1	YTH domain-containing family protein 3 isoform c
NM_001277818.2	NP_001264747.1	YTH domain-containing family protein 3 isoform c
NM_152758.6	NP_689971.4	YTH domain-containing family protein 3 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables N6-methyladenosine-containing RNA reader activity	IDA IDA: 通过直接分析推断	22575960	GOA
enables RNA binding	IDA IDA: 通过直接分析推断	32194978	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	22190034	GOA
enables ribosome binding	IDA IDA: 通过直接分析推断	28106076	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mRNA destabilization	IDA IDA: 通过直接分析推断	32492408	GOA
involved in mRNA destabilization	IMP IMP: 通过突变表型推断	28106072	GOA
involved in organelle assembly	IDA IDA: 通过直接分析推断	31292544	GOA
involved in positive regulation of translation	IMP IMP: 通过突变表型推断	28106072	GOA
NOT involved in positive regulation of translational initiation	IDA IDA: 通过直接分析推断	32492408	GOA
involved in positive regulation of translational initiation	IDA IDA: 通过直接分析推断	28106076	GOA
involved in regulation of mRNA stability	IDA IDA: 通过直接分析推断	32492408	GOA
involved in regulation of mRNA stability	IMP IMP: 通过突变表型推断	32194978	GOA
involved in regulation of trophoblast cell migration	IMP IMP: 通过突变表型推断	32194978	GOA
involved in stress granule assembly	IDA IDA: 通过直接分析推断	32451507	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in P-body	IDA IDA: 通过直接分析推断	32492408	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	32492408	GOA
located in cytoplasmic stress granule	IDA IDA: 通过直接分析推断	32451507	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

YTHDF3 蛋白结构

YTH

0
100
200
300
400
500
584 a.a.

蛋白主名

其他名称

YTH domain-containing family protein 3

YTH N(6)-methyladenosine RNA binding protein 3

YTHDF3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	YTHDF3	Q7Z739	YTHDF1	Homo sapiens	Q9BYJ9	Anti Tag CoIP	28514442
种属内	YTHDF3	Q7Z739	YTHDF1	Homo sapiens	Q9BYJ9	Anti Tag CoIP	33961781
种属内	YTHDF3	Q7Z739	FAF1	Homo sapiens	Q9UNN5	Validated Y2H	32296183
种属内	YTHDF3	Q7Z739	FAF1	Homo sapiens	Q9UNN5	Y2H Array	32296183
种属内	YTHDF3	Q7Z739	FAF1	Homo sapiens	Q9UNN5	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Retinitis Pigmentosa 11

RP11	Retinitis Pigmentosa-11
Retinitis Pigmentosa, Type 11

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15939	YTHDF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-168610	YTH-IN-1		/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	YTHDF3	VGNC	VGNC:37043
Rattus norvegicus	YTHDF3	RGD	RGD:1305234
Macaca mulatta	YTHDF3	VGNC	VGNC:79614
Mus musculus	YTHDF3	MGD	MGI:1918850
Felis catus	YTHDF3	VGNC	VGNC:67153
Canis familiaris	YTHDF3	VGNC	VGNC:48507

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