FAF1 - Fas associated factor 1 Gene

中文名称：Fas 相关因子 1

种属: Homo sapiens

同用名: hFAF1; CGI-03; HFAF1s; UBXD12; UBXN3A

基因 ID: 11124 | 基因类型: protein coding

关于 FAF1

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:50,437,028-50,960,267 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 31.0), thyroid (RPKM 14.4) and 25 other tissues.

功能概要

Fas 配体 (TNFSF6) 与 FAS 抗原 (TNFRSF6) 的相互作用介导许多器官系统中的程序性细胞死亡，也称为细胞凋亡。该基因编码的蛋白质与 FAS 抗原结合，可以启动细胞凋亡或增强通过 FAS 抗原启动的细胞凋亡。由该基因编码的蛋白质启动细胞凋亡需要泛素样结构域而不是 FAS 结合结构域。[RefSeq 提供，2008 年 7 月]

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called Apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate Apoptosis or enhance Apoptosis initiated through FAS antigen. Initiation of Apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]

FAF1 基因产物(1)

mRNA	Protein	Name
NM_007051.3	NP_008982.1	FAS-associated factor 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables NF-kappaB binding	IPI IPI: 通过物理相互作用推断	14600157	GOA
enables heat shock protein binding	IDA IDA: 通过直接分析推断	15596450	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15688372	GOA
enables protein kinase binding	IDA IDA: 通过直接分析推断	11713579	GOA
enables ubiquitin binding	IDA IDA: 通过直接分析推断	18775313	GOA
enables ubiquitin protein ligase binding	IDA IDA: 通过直接分析推断	18775313	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cytoplasmic sequestering of NF-kappaB	IMP IMP: 通过突变表型推断	14600157	GOA
involved in positive regulation of DNA replication	IMP IMP: 通过突变表型推断	26842564	GOA
involved in positive regulation of protein catabolic process	IMP IMP: 通过突变表型推断	26842564	GOA
involved in positive regulation of protein-containing complex assembly	IMP IMP: 通过突变表型推断	15688372	GOA
involved in regulation of protein catabolic process	IMP IMP: 通过突变表型推断	15743842	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of VCP-NPL4-UFD1 AAA ATPase complex	IDA IDA: 通过直接分析推断	18775313	GOA
located in cytosol	IDA IDA: 通过直接分析推断	15596450	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15596450	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	11713579	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FAF1 蛋白结构

UBA_4

UBX

0
100
200
300
400
500
600
650 a.a.

蛋白主名

其他名称

FAS-associated factor 1

Fas (TNFRSF6) associated factor 1

FAF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FAF1	Q9UNN5	VCP	Homo sapiens	P55072	Anti Tag CoIP	33961781
种属内	FAF1	Q9UNN5	VCP	Homo sapiens	P55072	Anti Tag CoIP	18775313

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Joubert Syndrome 31

JBTS31

Brugada Syndrome 9

BRGDA9

Brugada Syndrome, Type 9

Amyotrophic Lateral Sclerosis Type 14

Als14	Amyotrophic Lateral Sclerosis 14
Amyotrophic Lateral Sclerosis, With Or Without Frontotemporal Dementia	Amyotrophic Lateral Sclerosis 14 With Or Without Frontotemporal Dementia

Amyotrophic Lateral Sclerosis 8

Amyotrophic Lateral Sclerosis Type 8	ALS8
Sclerosis, Lateral, Amyotrophic, Type Type 8

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia
Pagetoid Amyotrophic Lateral Sclerosis	Pagetoid Neuroskeletal Syndrome
Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia
Multisystem Proteinopathy	Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone
Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement
Lower Motor Neuron Degeneration With Paget-Like Bone Disease	Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone
Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100755	KR-33493	Inhibitor	99.94%	否
HY-RS04670	FAF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	FAF1	RGD	RGD:70987
Mus musculus	FAF1	MGD	MGI:109419
Bos taurus	FAF1	VGNC	VGNC:28705
Canis familiaris	FAF1	VGNC	VGNC:40567
Macaca mulatta	FAF1	VGNC	VGNC:72474
Felis catus	FAF1	VGNC	VGNC:80204

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FAF1 - Fas associated factor 1 Gene

关于 FAF1

功能概要

FAF1 基因产物(1)

FAF1 蛋白结构

FAF1 蛋白互作信息

关联疾病

直系同源

热门区域

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FAF1 - Fas associated factor 1 Gene

关于 FAF1

功能概要

FAF1 基因产物(1)

FAF1 蛋白结构

FAF1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z