MAGED1 - MAGE family member D1 Gene

中文名称：MAGE 家族成员 D1

种属: Homo sapiens

同用名: NRAGE; DLXIN-1

基因 ID: 9500 | 基因类型: protein coding

关于 MAGED1

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:51,803,076-51,902,354 (from NCBI)

This gene has 10 transcripts (splice variants), 177 orthologues and 37 paralogues. Ubiquitous expression in brain (RPKM 56.4), placenta (RPKM 55.0) and 25 other tissues.

功能概要

该基因是黑色素瘤抗原基因 (MAGE) 家族的成员。这个家族的大多数基因编码肿瘤特异性抗原，这些抗原在除睾丸外的正常成人组织中不表达。尽管该基因编码的蛋白质与 MAGE 家族成员具有很强的同源性，但它在几乎所有正常成人组织中都有表达。该基因已被证明参与 p75 神经营养蛋白受体介导的程序性细胞死亡途径。已发现该基因编码两种不同亚型的三种转录变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MAGED1 基因产物(3)

mRNA	Protein	Name
NM_001005332.2	NP_001005332.1	melanoma-associated antigen D1 isoform b
NM_001005333.2	NP_001005333.1	melanoma-associated antigen D1 isoform a
NM_006986.4	NP_008917.3	melanoma-associated antigen D1 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15930293	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of epithelial cell proliferation	IDA IDA: 通过直接分析推断	15930293	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of protein-containing complex	IDA IDA: 通过直接分析推断	15930293	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAGED1 蛋白结构

MAGE

0
200
400
600
778 a.a.

蛋白主名

其他名称

melanoma-associated antigen D1

MAGE tumor antigen CCF

MAGED1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MAGED1	Q9Y5V3	SNRPC	Homo sapiens	Q5TAL4	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	KRTAP19-5	Homo sapiens	Q3LI72	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	LARP4B	Homo sapiens	Q92615	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	LARP4B	Homo sapiens	Q92615	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	PRKAB2	Homo sapiens	O43741	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	CERCAM	Homo sapiens	Q5T4B2	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	CERCAM	Homo sapiens	Q5T4B2	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	NOTO	Homo sapiens	A8MTQ0	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	NOTO	Homo sapiens	A8MTQ0	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	FOXH1	Homo sapiens	O75593	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	CAPN7	Homo sapiens	Q9Y6W3	Validated Y2H	32296183
Intra	MAGED1	Q9Y5V3	SMAP2	Homo sapiens	Q8WU79	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	KPNA2	Homo sapiens	P52292	Y2H Array	31515488
Intra	MAGED1	Q9Y5V3	KPNA2	Homo sapiens	P52292	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	KPNA2	Homo sapiens	P52292	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	KPNA2	Homo sapiens	P52292	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	TFG	Homo sapiens	Q92734	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	TFG	Homo sapiens	Q92734	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	KPNA6	Homo sapiens	O60684	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	KPNA6	Homo sapiens	O60684	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	SMN1	Homo sapiens	Q16637	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	SMN1	Homo sapiens	Q16637	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	EIF4E2	Homo sapiens	O60573	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	EIF4E2	Homo sapiens	O60573	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	BHLHE40	Homo sapiens	O14503	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	PJA1	Homo sapiens	Q8NG27	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	PJA1	Homo sapiens	Q8NG27	Anti Tag CoIP	20864041
Intra	MAGED1	Q9Y5V3	PJA1	Homo sapiens	Q8NG27	Pull Down	20864041
Intra	MAGED1	Q9Y5V3	PJA1	Homo sapiens	Q8NG27	IF	20864041
Intra	MAGED1	Q9Y5V3	PJA1	Homo sapiens	Q8NG27	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	PJA1	Homo sapiens	Q8NG27	Anti Bait CoIP	20864041
Intra	MAGED1	Q9Y5V3	CA8	Homo sapiens	P35219	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	CA8	Homo sapiens	P35219	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	MDFI	Homo sapiens	Q99750	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	MAGED1	Q9Y5V3	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	MAGED1	Q9Y5V3	RBPMS	Homo sapiens	Q93062	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	BAG3	Homo sapiens	O95817	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	BAG3	Homo sapiens	O95817	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	CD2BP2	Homo sapiens	O95400	Peptide Array	16000308
Intra	MAGED1	Q9Y5V3	CD2BP2	Homo sapiens	O95400	Protein Array	16000308
Intra	MAGED1	Q9Y5V3	RBM23	Homo sapiens	Q86U06	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	RBM23	Homo sapiens	Q86U06	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	RBM23	Homo sapiens	Q86U06	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	DAB1	Homo sapiens	O75553	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	TTC32	Homo sapiens	Q5I0X7	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	TTC32	Homo sapiens	Q5I0X7	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	TTC32	Homo sapiens	Q5I0X7	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	ZNF488	Homo sapiens	Q96MN9	Y2H Array	25416956
Intra	MAGED1	Q9Y5V3	ZNF488	Homo sapiens	Q96MN9	Y2H Prey Pooling	25416956
Intra	MAGED1	Q9Y5V3	AKAP9	Homo sapiens	Q99996-2	Validated Y2H	25416956
Intra	MAGED1	Q9Y5V3	AKAP9	Homo sapiens	Q99996-2	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Schaaf-Yang Syndrome

Prader-Willi-Like Syndrome	Chitayat-Hall Syndrome
SHFYNG	Pwls
Magel2-Related Prader-Willi-Like Syndrome	Magel2-Related Pwls
Arthrogryposis, Distal, With Hypopituitarism, Mental Retardation, And Facial Anomalies	Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial A
Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial Anomalies	Pws Due To A Point Mutation
Pws Due To Point Mutation	Prader-Willi Syndrome Due To A Point Mutation
Prader-Willi Syndrome Due To Point Mutation	Pws-Like

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07976	MAGED1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	MAGED1	MGD	MGI:1930187
Canis familiaris	MAGED1	VGNC	VGNC:42924
Bos taurus	MAGED1	VGNC	VGNC:55062
Rattus norvegicus	MAGED1	RGD	RGD:70898
Macaca mulatta	MAGED1	VGNC	VGNC:74479

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4