MAGED1 - MAGE family member D1 Gene

中文名称：MAGE 家族成员 D1

种属: Homo sapiens

同用名: NRAGE; DLXIN-1

关于 MAGED1

功能概要

该基因是黑色素瘤抗原基因 (MAGE) 家族的成员。这个家族的大多数基因编码肿瘤特异性抗原，这些抗原在除睾丸外的正常成人组织中不表达。尽管该基因编码的蛋白质与 MAGE 家族成员具有很强的同源性，但它在几乎所有正常成人组织中都有表达。该基因已被证明参与 p75 神经营养蛋白受体介导的程序性细胞死亡途径。已发现该基因编码两种不同亚型的三种转录变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]