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  2. LARP4B - La ribonucleoprotein 4B Gene

LARP4B - La ribonucleoprotein 4B Gene

中文名称:核糖核蛋白 4B

种属: Homo sapiens

同用名: LARP5; KIAA0217

基因 ID: 23185 | 基因类型: protein coding

关于 LARP4B

Cytogenetic location: 10p15.3 Genomic coordinates (GRCh38): 10:806,914-988,341 (from NCBI)

This gene has 17 transcripts (splice variants), 268 orthologues, 6 paralogues and is associated with 70 phenotypes. Ubiquitous expression in thyroid (RPKM 6.7), testis (RPKM 6.0) and 25 other tissues.

功能概要

该基因编码参与 RNA 代谢和翻译的进化保守蛋白家族的成员。该家族成员的特征是存在 La 基序,该基序通常位于一个或多个 RNA 识别基序 (RRM) 附近。这两个基序共同构成了蛋白质的功能区域,并使其能够与 RNA 底物相互作用。该蛋白质家族分为五个亚家族:真正的 La 蛋白和四个 La 相关蛋白 (LARP) 亚家族。该基因编码的蛋白质属于 LARP 亚家族 4。它是一种细胞质蛋白,可能在翻译中发挥刺激作用。[RefSeq 提供,2012 年 10 月]

This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012]

LARP4B 基因产物(2)

mRNA Protein Name
NM_001351277.2 NP_001338206.1 la-related protein 4B isoform 2
NM_015155.3 NP_055970.1 la-related protein 4B isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
26001795 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21988832 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of 3'-UTR-mediated mRNA stabilization IMP
IMP: 通过突变表型推断
26001795 GOA
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
20573744 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
20573744 GOA
located in cytosol IDA
IDA: 通过直接分析推断
20573744 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LARP4B 蛋白结构

La

La: La domain (160 - 216)

  • 0
  • 200
  • 400
  • 600
  • 738 a.a.
蛋白主名 其他名称

la-related protein 4B

La ribonucleoprotein domain family member 4B

LARP4B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LARP4B Q92615 SARS1 Homo sapiens P49591
Validated Y2H
32814053
种属内
LARP4B Q92615 SARS1 Homo sapiens P49591
Y2H Array
32814053
种属内
LARP4B Q92615 SARS1 Homo sapiens P49591
Y2H Pooling
32814053
种属内
LARP4B Q92615 EIF2S3 Homo sapiens P41091
Validated Y2H
32814053
种属内
LARP4B Q92615 EIF2S3 Homo sapiens P41091
Y2H Array
32814053
种属内
LARP4B Q92615 EIF2S3 Homo sapiens P41091
Y2H Pooling
32814053
种属内
LARP4B Q92615 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Array
32814053
种属内
LARP4B Q92615 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Pooling
32814053
种属内
LARP4B Q92615 GTF3C3 Homo sapiens Q9Y5Q9
Validated Y2H
32814053
种属内
LARP4B Q92615 BACE2 Homo sapiens Q9Y5Z0
Y2H Array
32814053
种属内
LARP4B Q92615 BACE2 Homo sapiens Q9Y5Z0
Y2H Pooling
32814053
种属内
LARP4B Q92615 BACE2 Homo sapiens Q9Y5Z0
Validated Y2H
32814053
种属内
LARP4B Q92615 ERN1 Homo sapiens O75460-2
Y2H Pooling
32814053
种属内
LARP4B Q92615 ERN1 Homo sapiens O75460-2
Validated Y2H
32814053
种属内
LARP4B Q92615 ERN1 Homo sapiens O75460-2
Y2H Array
32814053
种属内
LARP4B Q92615 RACK1 Homo sapiens P63244
Anti Tag CoIP
33961781
种属内
LARP4B Q92615 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
种属内
LARP4B Q92615 F11R Homo sapiens Q9Y624
Validated Y2H
32814053
种属内
LARP4B Q92615 F11R Homo sapiens Q9Y624
Y2H Pooling
32814053
种属内
LARP4B Q92615 F11R Homo sapiens Q9Y624
Y2H Array
32814053
种属内
LARP4B Q92615 PABPC1 Homo sapiens P11940
Anti Tag CoIP
33961781
种属内
LARP4B Q92615 e9kl35_human Homo sapiens E9KL35
Y2H Prey Pooling
25416956
种属内
LARP4B Q92615 e9kl35_human Homo sapiens E9KL35
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nephronophthisis 3

NPHP3

Nph3

Adolescent Nephronophthisis

Nephronophthisis, Type 3

Hypoparathyroidism-Deafness-Renal Disease Syndrome

Barakat Syndrome

Hypoparathyroidism, Deafness, Renal Disease Syndrome

Hdr Syndrome

Hypoparathyroidism, Sensorineural Deafness, And Renal Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LARP4B RGD RGD:1310713
Felis catus LARP4B VGNC VGNC:63194
Bos taurus LARP4B VGNC VGNC:30792
Mus musculus LARP4B MGD MGI:106330
Macaca mulatta LARP4B VGNC VGNC:74153