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  3. SARS1 - seryl-tRNA synthetase 1 Gene

SARS1 - seryl-tRNA synthetase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：seryl-tRNA 合成酶 1

种属: Homo sapiens

同用名: SARS; SERS; SERRS; NEDMAS

基因 ID: 6301 | 基因类型: protein coding

关于 SARS1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,213,893-109,238,182 (from NCBI)

This gene has 6 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 44.0), brain (RPKM 25.3) and 25 other tissues.

功能概要

该基因属于 II 类氨酰 tRNA 家族。编码的酶催化 L-丝氨酸向 tRNA (Ser) 的转移，并且与细菌和酵母对应物有关。已经描述了多个选择性剪接的转录本变体，但所有变体的生物学有效性尚不清楚。[RefSeq 提供，2010 年 7 月]

This gene belongs to the class II amino-acyl tRNA family. The encoded Enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to Bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

SARS1 基因产物(2)

mRNA Protein Name
NM_001330669.1 NP_001317598.1 serine--tRNA ligase, cytoplasmic isoform b
NM_006513.4 NP_006504.2 serine--tRNA ligase, cytoplasmic isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
24940000 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
28655767 GOA
enables molecular adaptor activity IDA
IDA: 通过直接分析推断
34268557 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
26433229 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
26433229 GOA
enables selenocysteine-tRNA ligase activity IMP
IMP: 通过突变表型推断
34570399 GOA
enables serine-tRNA ligase activity IDA
IDA: 通过直接分析推断
24095058 GOA
enables serine-tRNA ligase activity IMP
IMP: 通过突变表型推断
34570399 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoplasmic translation IMP
IMP: 通过突变表型推断
36041817 GOA
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
24940000 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
24940000 GOA
involved in negative regulation of vascular endothelial growth factor production IDA
IDA: 通过直接分析推断
24940000 GOA
involved in selenocysteine incorporation IMP
IMP: 通过突变表型推断
34570399 GOA
involved in seryl-tRNA aminoacylation IDA
IDA: 通过直接分析推断
24095058 GOA
involved in seryl-tRNA aminoacylation IMP
IMP: 通过突变表型推断
28236339 GOA
involved in tRNA modification IDA
IDA: 通过直接分析推断
34268557 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
28236339 GOA
located in cytosol IDA
IDA: 通过直接分析推断
34570399 GOA
located in nucleus IDA
IDA: 通过直接分析推断
34570399 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SARS1 蛋白结构

Seryl_tRNA_N

Seryl_tRNA_N: Seryl-tRNA synthetase N-terminal domain (2 - 92)

tRNA-synt_2b

tRNA-synt_2b: tRNA synthetase class II core domain (G, H, P, S and T) (203 - 384)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
蛋白主名 其他名称

serine--tRNA ligase, cytoplasmic

serine tRNA ligase 1, cytoplasmic

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Microcephaly, Ataxia, And Seizures

NEDMAS
Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation

Intracranial Arteriovenous Malformation

Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To

Intracranial Arteriovenous Malformations

Bavm

Cerebral Arteriovenous Malformations

Intracranial Hemorrhage In Brain Cerebrovascular Malformations

Arteriovenous Malformation Of The Brain, Somatic

Intracranial Avm

Arteriovenous Malformations Cerebral
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
Hyperuricemia

Blood Urate Raized

Uricacidemia
Joubert Syndrome 7

JBTS7

Cerebello-Oculo-Renal Syndrome 3

Cors3

Joubert Syndrome, Type 7
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P0205B Saralasin TFA Antagonist 99.65% 否
HY-P1564A [Sar1, Ile8]-Angiotensin II TFA 99.70% 否
HY-P0205 Saralasin Antagonist / 否
HY-P0205A Saralasin acetate hydrate Antagonist / 否
HY-P1564 [Sar1, Ile8]-Angiotensin II / 否
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P4685 (Sar1,Ile4,8)-Angiotensin II Agonist 98.69% 否
HY-P3138 (Sar1)-Angiotensin II Agonist 99.84% 否
HY-P10640 [Sar1,Thr8]-Angiotensin II Antagonist / 否
HY-RS12442 SAR1A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12443 SAR1B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12448 SARS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-101823A A-81282 Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SARS1 MGD MGI:102809
Bos taurus SARS1 VGNC VGNC:34291
Canis familiaris SARS1 VGNC VGNC:45869
Rattus norvegicus SARS1 RGD RGD:628813
Macaca mulatta SARS1 VGNC VGNC:100131
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