2. GPCR/G Protein
  3. Angiotensin Receptor
  4. (Sar1)-Angiotensin II

(Sar1)-Angiotensin II 

目录号: HY-P3138 纯度: 99.84%
COA 产品使用指南

摩尔计算器

(Sar1)-Angiotensin II，一种血管紧张素 II (Angiotensin II) 的类似物，是血管紧张素 AT1 受体的特异性激动剂。(Sar1)-Angiotensin II 以 2.7 nM 的 Kd 值结合到富含脑膜的颗粒上。(Sar1)-Angiotensin II 可以刺激雏鸡心肌细胞中的蛋白质合成和细胞生长。

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Custom Peptide Synthesis

(Sar1)-Angiotensin II Chemical Structure

(Sar1)-Angiotensin II Chemical Structure

CAS No. : 51833-69-3

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规格 价格 是否有货 数量
1 mg ￥1600
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5 mg ￥3500
In-stock
10 mg ￥5800
In-stock
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Customer Review

(Sar1)-Angiotensin II 相关抗体

Top Publications Citing Use of Products

查看 Angiotensin Receptor 亚型特异性产品:

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AT1 Receptor AT2 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. (Sar1)-Angiotensin II binds to brain membrane-rich particles, with a Kd of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes[1][2][3].

IC50 & Target

AT1 Receptor

 

体外研究
(In Vitro)

(Sar1)-Angiotensin II (1 μM/day; 9 d) increases the total protein content in embryonic chick myocytes by 18.5, 26.2, and 22.2% at 5, 7, and 9 days, respectively[2].
(Sar1)-Angiotensin II binds to brain membrane-rich particles in cynomolgus monkey brain, with a Kd of 2.7 nM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(Sar1)-Angiotensin II 相关抗体:
分子量

1002.17

Formula

C49H71N13O10
CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

{Sar}-RVYIHPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

(Sar1)-Angiotensin II 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Sar1)-Angiotensin II51833-69-3Angiotensin ReceptorangiotensinAT1proteinembryonicchickmyocytesInhibitorinhibitorinhibit

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