2. Gene
  3. SWAP70 - switching B cell complex subunit SWAP70 Gene

SWAP70 - switching B cell complex subunit SWAP70 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：转换 B 细胞复合亚基 SWAP70

种属: Homo sapiens

同用名: HSPC321; SWAP-70

基因 ID: 23075 | 基因类型: protein coding

关于 SWAP70

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,664,077-9,752,993 (from NCBI)

This gene has 7 transcripts (splice variants), 282 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 33.7), spleen (RPKM 30.6) and 24 other tissues.

功能概要

启用钙粘蛋白结合活动。预计参与调节肌动蛋白聚合或解聚。预计在同种型转换的上游或内部起作用。位于肌动蛋白细胞骨架；细胞质；和质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables cadherin binding activity. Predicted to be involved in regulation of actin polymerization or depolymerization. Predicted to act upstream of or within isotype switching. Located in actin cytoskeleton; cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SWAP70 基因产物(2)

mRNA Protein Name
NM_001297714.2 NP_001284643.1 switch-associated protein 70 isoform 2
NM_015055.4 NP_055870.2 switch-associated protein 70 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24722188 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
25468996 GOA
is active in postsynapse IDA
IDA: 通过直接分析推断
30123108 GOA
is active in postsynapse IMP
IMP: 通过突变表型推断
30123108 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SWAP70 蛋白结构

PH

PH: PH domain (212 - 305)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 585 a.a.
蛋白主名 其他名称

switch-associated protein 70

SWAP switching B-cell complex 70kDa subunit

关联疾病

疾病名称 别名
Aleutian Mink Disease

Aleutian Disease
B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable
Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14063 SWAP70 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SWAP70 VGNC VGNC:78142
Felis catus SWAP70 VGNC VGNC:65867
Bos taurus SWAP70 VGNC VGNC:54893
Canis familiaris SWAP70 VGNC VGNC:47009
Rattus norvegicus SWAP70 RGD RGD:1305579
Mus musculus SWAP70 MGD MGI:1298390
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