SOCS6 - suppressor of cytokine signaling 6 Gene

中文名称：细胞因子信号抑制因子 6

种属: Homo sapiens

同用名: CIS4; SSI4; CIS-4; SOCS4; STAI4; SOCS-4; SOCS-6; STATI4; HSPC060

关于 SOCS6

功能概要

该基因编码的蛋白质包含一个 SH2 结构域和一个 CIS 同源结构域。因此，该蛋白质属于细胞因子诱导的 STAT 抑制剂 (CIS) ，也称为细胞因子信号转导抑制因子 (SOCS) 或 STAT 诱导的 STAT 抑制剂 (SSI) 蛋白质家族。已知 CIS 家族成员是细胞因子信号转导的细胞因子诱导型负调节因子。该基因的表达可以在造血细胞中被 GM-CSF 和 EPO 诱导。在因子非依赖性慢性粒细胞白血病 (CML) 和红白血病 (HEL) 细胞系中发现了该基因的高表达水平。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT Inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT Inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]