2. Gene
  3. ARIH2 - ariadne RBR E3 ubiquitin protein ligase 2 Gene

ARIH2 - ariadne RBR E3 ubiquitin protein ligase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ariadne RBR E3 泛素蛋白连接酶 2

种属: Homo sapiens

同用名: ARI2; TRIAD1

基因 ID: 10425 | 基因类型: protein coding

关于 ARIH2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,918,842-48,986,382 (from NCBI)

This gene has 31 transcripts (splice variants), 213 orthologues and 9 paralogues. Ubiquitous expression in thyroid (RPKM 18.6), heart (RPKM 17.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质是一种 E3 泛素蛋白连接酶，可将一些蛋白质多泛素化，标记它们以进行降解。编码的蛋白质上调某些癌细胞中的 p53，并可能抑制骨髓细胞生成。已发现该基因编码不同亚型的几种转录变体，尽管其中一些的全长性质尚未确定。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is an E3 ubiquitin-protein Ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some Cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]

ARIH2 基因产物(25)

mRNA Protein Name
NM_001317333.2 NP_001304262.1 E3 ubiquitin-protein ligase ARIH2 isoform a
NM_001317334.2 NP_001304263.1 E3 ubiquitin-protein ligase ARIH2 isoform b
NM_001349209.2 NP_001336138.1 E3 ubiquitin-protein ligase ARIH2 isoform a
NM_001349210.2 NP_001336139.1 E3 ubiquitin-protein ligase ARIH2 isoform a
NM_001349211.2 NP_001336140.1 E3 ubiquitin-protein ligase ARIH2 isoform a
NM_001349212.2 NP_001336141.1 E3 ubiquitin-protein ligase ARIH2 isoform b
NM_001349213.2 NP_001336142.1 E3 ubiquitin-protein ligase ARIH2 isoform c
NM_001349214.2 NP_001336143.1 E3 ubiquitin-protein ligase ARIH2 isoform c
NM_001349215.2 NP_001336144.1 E3 ubiquitin-protein ligase ARIH2 isoform d
NM_001349216.2 NP_001336145.1 E3 ubiquitin-protein ligase ARIH2 isoform e precursor
NM_001349217.2 NP_001336146.1 E3 ubiquitin-protein ligase ARIH2 isoform f precursor
NM_001349218.2 NP_001336147.1 E3 ubiquitin-protein ligase ARIH2 isoform f precursor
NM_001349219.2 NP_001336148.1 E3 ubiquitin-protein ligase ARIH2 isoform f precursor
NM_001349220.2 NP_001336149.1 E3 ubiquitin-protein ligase ARIH2 isoform f precursor
NM_001349221.2 NP_001336150.1 E3 ubiquitin-protein ligase ARIH2 isoform f precursor
NM_001349222.2 NP_001336151.1 E3 ubiquitin-protein ligase ARIH2 isoform g
NM_001349223.2 NP_001336152.1 E3 ubiquitin-protein ligase ARIH2 isoform g
NM_001349224.2 NP_001336153.1 E3 ubiquitin-protein ligase ARIH2 isoform g
NM_001349225.2 NP_001336154.1 E3 ubiquitin-protein ligase ARIH2 isoform g
NM_001349226.2 NP_001336155.1 E3 ubiquitin-protein ligase ARIH2 isoform g
NM_001349227.2 NP_001336156.1 E3 ubiquitin-protein ligase ARIH2 isoform h
NM_001349228.2 NP_001336157.1 E3 ubiquitin-protein ligase ARIH2 isoform i
NM_001349229.2 NP_001336158.1 E3 ubiquitin-protein ligase ARIH2 isoform i
NM_001349230.2 NP_001336159.1 E3 ubiquitin-protein ligase ARIH2 isoform i
NM_006321.4 NP_006312.1 E3 ubiquitin-protein ligase ARIH2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16118314 GOA
enables ubiquitin conjugating enzyme binding IPI
IPI: 通过物理相互作用推断
24076655 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
31253590 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
16118314 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in developmental cell growth IDA
IDA: 通过直接分析推断
19340006 GOA
involved in hematopoietic stem cell proliferation IDA
IDA: 通过直接分析推断
16118314 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
31253590 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
16118314 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
19340006 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
16118314 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
24076655 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
16118314 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul5-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
24076655 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
19340006 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16118314 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARIH2 蛋白结构

IBR

IBR: IBR domain, a half RING-finger domain (208 - 270)

IBR

IBR: IBR domain, a half RING-finger domain (293 - 333)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase ARIH2

RING-type E3 ubiquitin transferase ARIH2

ARIH2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ARIH2 O95376 CUL5 Homo sapiens Q93034
Anti Bait CoIP
24076655
Intra ARIH2 O95376 CUL5 Homo sapiens Q93034
Anti Tag CoIP
24076655
Intra ARIH2 O95376 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra ARIH2 O95376 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra ARIH2 O95376 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra ARIH2 O95376 UBE2L6 Homo sapiens O14933
Y2H Array
25416956
Intra ARIH2 O95376 UBE2L6 Homo sapiens O14933
Y2H Prey Pooling
25416956
Intra ARIH2 O95376 REL Homo sapiens Q04864
Y2H Array
25416956
Intra ARIH2 O95376 TP53 Homo sapiens P04637
Y2H Pooling
16169070
Intra ARIH2 O95376 TP53 Homo sapiens P04637
Pull Down
22819825
Intra ARIH2 O95376 TP53 Homo sapiens P04637
Anti Tag CoIP
22819825
Intra ARIH2 O95376 UBE2L3 Homo sapiens P68036
Validated Y2H
32296183
Intra ARIH2 O95376 UBE2L3 Homo sapiens P68036
Y2H Array
32296183
Intra ARIH2 O95376 UBE2L3 Homo sapiens P68036
Anti Bait CoIP
24076655
Intra ARIH2 O95376 UBE2L3 Homo sapiens P68036
Anti Tag CoIP
24076655
Intra ARIH2 O95376 UBE2L3 Homo sapiens P68036
Y2H Prey Pooling
32296183
Intra ARIH2 O95376 UBE2L3 Homo sapiens P68036
Y2H
19549727
Intra ARIH2 O95376 UBE2L3 Homo sapiens P68036
Y2H Pooling
16169070
Intra ARIH2 O95376 UBE2L3 Homo sapiens P68036
Y2H Array
19549727
Intra ARIH2 O95376 UGP2 Homo sapiens Q16851
Validated Y2H
25416956
Intra ARIH2 O95376 UGP2 Homo sapiens Q16851
Validated Y2H
32296183
Intra ARIH2 O95376 UGP2 Homo sapiens Q16851
Y2H Array
32296183
Intra ARIH2 O95376 UGP2 Homo sapiens Q16851
Y2H Prey Pooling
32296183
Intra ARIH2 O95376 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra ARIH2 O95376 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra ARIH2 O95376 PAX6 Homo sapiens P26367
Validated Y2H
32296183
Intra ARIH2 O95376 CRX Homo sapiens O43186
Y2H Prey Pooling
32296183
Intra ARIH2 O95376 CRX Homo sapiens O43186
Y2H Array
32296183
Intra ARIH2 O95376 BUB1 Homo sapiens O43683
Y2H Prey Pooling
32296183
Intra ARIH2 O95376 BUB1 Homo sapiens O43683
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00976 ARIH2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ARIH2 VGNC VGNC:38103
Rattus norvegicus ARIH2 RGD RGD:1305839
Felis catus ARIH2 VGNC VGNC:68189
Macaca mulatta ARIH2 VGNC VGNC:110385
Bos taurus ARIH2 VGNC VGNC:26134
Mus musculus ARIH2 MGD MGI:1344361
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z