CUL5 - cullin 5 Gene

中文名称：卡林 5

种属: Homo sapiens

同用名: CUL-5; VACM1; VACM-1

基因 ID: 8065 | 基因类型: protein coding

关于 CUL5

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:108,008,898-108,107,761 (from NCBI)

This gene has 6 transcripts (splice variants), 263 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 9.9), kidney (RPKM 8.6) and 25 other tissues.

功能概要

启用泛素蛋白连接酶结合活性。预计参与 SCF 依赖的蛋白酶体泛素依赖性蛋白质分解代谢过程和蛋白质泛素化。预计作用于大脑皮层上游或内部径向定向细胞迁移和径向胶质细胞引导的浦肯野细胞迁移。位于 DNA 损伤部位。 Cul5-RING 泛素连接酶复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables ubiquitin protein Ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within cerebral cortex radially oriented cell migration and radial glia guided migration of Purkinje cell. Located in site of DNA damage. Part of Cul5-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

CUL5 基因产物(1)

mRNA	Protein	Name
NM_003478.6	NP_003469.2	cullin-5

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12504025	GOA
enables ubiquitin ligase complex scaffold activity	IDA IDA: 通过直接分析推断	22190037	GOA
enables ubiquitin protein ligase binding	IDA IDA: 通过直接分析推断	17636018	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	21980433	GOA
involved in protein K11-linked ubiquitination	IDA IDA: 通过直接分析推断	27910872	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Cul5-RING ubiquitin ligase complex	IDA IDA: 通过直接分析推断	17636018	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	38418882	GOA
located in site of DNA damage	IDA IDA: 通过直接分析推断	28292928	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CUL5 蛋白结构

Cullin

Cullin_Nedd8

0
200
400
600
780 a.a.

蛋白主名

其他名称

cullin-5

Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1)

CUL5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CUL5	Q93034	ASB1	Homo sapiens	Q9Y576	TAP	21145461
Intra	CUL5	Q93034	ASB1	Homo sapiens	Q9Y576	Anti Tag CoIP	33961781
Intra	CUL5	Q93034	ASB1	Homo sapiens	Q9Y576	Anti Tag CoIP	28514442
Intra	CUL5	Q93034	ASB2	Homo sapiens	Q96Q27-2	Anti Tag CoIP	16325183
Intra	CUL5	Q93034	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	32296183
Intra	CUL5	Q93034	COG6	Homo sapiens	Q9Y2V7	Y2H Prey Pooling	32296183
Intra	CUL5	Q93034	COG6	Homo sapiens	Q9Y2V7	Y2H Array	32296183
Intra	CUL5	Q93034	ASB7	Homo sapiens	Q9H672	Anti Tag CoIP	33961781
Intra	CUL5	Q93034	ASB7	Homo sapiens	Q9H672	TAP	21145461
Intra	CUL5	Q93034	RBX1	Homo sapiens	P62877	X-Ray Diffraction	18805092
Intra	CUL5	Q93034	RNF7	Homo sapiens	Q9UBF6	Y2H Prey Pooling	32296183
Intra	CUL5	Q93034	RNF7	Homo sapiens	Q9UBF6	Validated Y2H	32296183
Intra	CUL5	Q93034	RNF7	Homo sapiens	Q9UBF6	Y2H	21516116
Intra	CUL5	Q93034	RNF7	Homo sapiens	Q9UBF6	Y2H Array	32296183
Intra	CUL5	Q93034	RNF7	Homo sapiens	Q9UBF6	Y2H Prey Pooling	25416956
Intra	CUL5	Q93034	RNF7	Homo sapiens	Q9UBF6	TAP	21145461
Intra	CUL5	Q93034	SOCS2	Homo sapiens	O14508	TAP	21145461
Intra	CUL5	Q93034	SOCS2	Homo sapiens	O14508	Anti Tag CoIP	33961781
Intra	CUL5	Q93034	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	CUL5	Q93034	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	CUL5	Q93034	ASB6	Homo sapiens	Q9NWX5	TAP	21145461
Intra	CUL5	Q93034	ASB6	Homo sapiens	Q9NWX5	Anti Tag CoIP	33961781
Intra	CUL5	Q93034	ARIH2	Homo sapiens	O95376	Anti Tag CoIP	33961781
Intra	CUL5	Q93034	ARIH2	Homo sapiens	O95376	Anti Bait CoIP	24076655
Intra	CUL5	Q93034	CCNB1IP1	Homo sapiens	Q9NPC3	Y2H Prey Pooling	32296183
Intra	CUL5	Q93034	CCNB1IP1	Homo sapiens	Q9NPC3	Validated Y2H	32296183
Intra	CUL5	Q93034	CCNB1IP1	Homo sapiens	Q9NPC3	Y2H Array	32296183
Intra	CUL5	Q93034	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	25416956
Intra	CUL5	Q93034	CCNDBP1	Homo sapiens	O95273	Y2H Array	31515488
Intra	CUL5	Q93034	CCNDBP1	Homo sapiens	O95273	Validated Y2H	25416956
Intra	CUL5	Q93034	KANK4	Homo sapiens	Q5T7N3	Y2H Array	32296183
Intra	CUL5	Q93034	KANK4	Homo sapiens	Q5T7N3	Y2H Prey Pooling	32296183
Cross	CUL5	Q93034	vif	Human immunodeficiency virus	P12504	GMS	24402281
Cross	CUL5	Q93034	vif	Human immunodeficiency virus	P12504	Ion Exchange Chrom	24402281
Cross	CUL5	Q93034	vif	Human immunodeficiency virus	P12504	X-Ray Diffraction	24402281
Cross	CUL5	Q93034	vif	Human immunodeficiency virus	P12504	Pull Down	24402281

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Three M Syndrome 1

3-M Syndrome	Yakut Short Stature Syndrome
3m Syndrome	Le Merrer Syndrome
Dolichospondylic Dysplasia	Gloomy Face Syndrome
Three M Syndrome	3M1
3m Syndrome 1	Miller-Mckusick-Malvaux Syndrome
3-Msbn	Three-M Slender-Boned Nanism
Miller-Mckusick-Malvaux-Syndrome	3-M Syndrome 1
3m Syndrome-1	3m Syndrome, Type 1
Dwarfism	Dwarfism Tall Vertebrae

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03364	CUL5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CUL5	MGD	MGI:1922967
Macaca mulatta	CUL5	VGNC	VGNC:71570
Bos taurus	CUL5	VGNC	VGNC:27834
Rattus norvegicus	CUL5	RGD	RGD:621742
Felis catus	CUL5	VGNC	VGNC:61286
Canis familiaris	CUL5	VGNC	VGNC:39733
Others	CUL5	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CUL5 - cullin 5 Gene

关于 CUL5

功能概要

CUL5 基因产物(1)

CUL5 蛋白结构

CUL5 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

CUL5 - cullin 5 Gene

关于 CUL5

功能概要

CUL5 基因产物(1)

CUL5 蛋白结构

CUL5 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z