1. Gene
  2. RBX1 - ring-box 1 Gene

RBX1 - ring-box 1 Gene

中文名称:戒指盒 1

种属: Homo sapiens

同用名: ROC1; RNF75; BA554C12.1

基因 ID: 9978 | 基因类型: protein coding

关于 RBX1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:40,951,378-40,973,309 (from NCBI)

This gene has 3 transcripts (splice variants), 223 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 27.7), bone marrow (RPKM 27.1) and 25 other tissues.

功能概要

该位点编码一个环指状结构域蛋白。编码的蛋白质与 cullin 蛋白质相互作用,并可能在细胞周期进程所必需的泛素化过程中发挥作用。这种蛋白质也可能影响蛋白质周转。相关假基因存在于 2 号和 5 号染色体上。[RefSeq 提供,2010 年 9 月]

This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]

RBX1 基因产物(1)

mRNA Protein Name
NM_014248.4 NP_055063.1 E3 ubiquitin-protein ligase RBX1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NEDD8 ligase activity IDA
IDA: 通过直接分析推断
19250909 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
14739464 GOA
enables cullin family protein binding IDA
IDA: 通过直接分析推断
10230407 GOA
enables cullin family protein binding IPI
IPI: 通过物理相互作用推断
14528312 GOA
enables molecular adaptor activity EXP
EXP: 通过实验结果推断
11961546 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11961546 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
10230407 GOA
enables ubiquitin protein ligase binding IDA
IDA: 通过直接分析推断
17636018 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
15983046 GOA
enables ubiquitin-ubiquitin ligase activity IDA
IDA: 通过直接分析推断
10230407 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response EXP
EXP: 通过实验结果推断
22118460 GOA
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
15103331 GOA
involved in T cell activation IDA
IDA: 通过直接分析推断
34065512 GOA
involved in cellular response to UV EXP
EXP: 通过实验结果推断
22118460 GOA
involved in cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
29769719 GOA
involved in negative regulation of response to oxidative stress IDA
IDA: 通过直接分析推断
11027288 GOA
involved in negative regulation of type I interferon production IDA
IDA: 通过直接分析推断
36394357 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
29769719 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
10644755 GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IPI
IPI: 通过物理相互作用推断
14739464 GOA
involved in positive regulation of protein autoubiquitination IMP
IMP: 通过突变表型推断
14528312 GOA
involved in positive regulation of protein catabolic process IDA
IDA: 通过直接分析推断
11027288 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
10230407 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
15103331 GOA
involved in protein monoubiquitination IDA
IDA: 通过直接分析推断
22358839 GOA
involved in protein neddylation IDA
IDA: 通过直接分析推断
19250909 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
14528312 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
15103331 GOA
involved in protein ubiquitination IPI
IPI: 通过物理相互作用推断
14739464 GOA
involved in spermatogenesis IDA
IDA: 通过直接分析推断
34065512 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
17636018 GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
IDA: 通过直接分析推断
29779948 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul2-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
17636018 GOA
part of Cul3-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
14528312 GOA
part of Cul4A-RING E3 ubiquitin ligase complex EXP
EXP: 通过实验结果推断
22118460 GOA
part of Cul4A-RING E3 ubiquitin ligase complex IDA
IDA: 通过直接分析推断
12732143 GOA
part of Cul4B-RING E3 ubiquitin ligase complex IDA
IDA: 通过直接分析推断
18794347 GOA
part of Cul5-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
17636018 GOA
part of Cul7-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
18498745 GOA
part of SCF ubiquitin ligase complex IDA
IDA: 通过直接分析推断
11956208 GOA
part of cullin-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
22405651 GOA
is active in cytoplasm IDA
IDA: 通过直接分析推断
34065512 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
11027288 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RBX1 蛋白结构

zf-rbx1

zf-rbx1: RING-H2 zinc finger domain (21 - 98)

  • 0
  • 100
  • 108 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RBX1

E3 ubiquitin-protein transferase RBX1

RBX1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RBX1 P62877 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
种属内
RBX1 P62877 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
种属内
RBX1 P62877 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
种属内
RBX1 P62877 PBX4 Homo sapiens Q9BYU1
Y2H Prey Pooling
32296183
种属内
RBX1 P62877 PBX4 Homo sapiens Q9BYU1
Y2H Array
32296183
种属内
RBX1 P62877 UBE2M Homo sapiens P61081
NMR
21765416
种属内
RBX1 P62877 UBE2M Homo sapiens P61081
Ubiquitinase Assay
24949976
种属内
RBX1 P62877 UBE2M Homo sapiens P61081
Y2H Prey Pooling
32296183
种属内
RBX1 P62877 UBE2M Homo sapiens P61081
Y2H Array
32296183
种属内
RBX1 P62877 UBE2M Homo sapiens P61081
Neddylase Assay
24949976
种属内
RBX1 P62877 CUL1 Homo sapiens Q13616
Ubiquitinase Assay
24949976
种属内
RBX1 P62877 CUL1 Homo sapiens Q13616
SAXS
18805092
种属内
RBX1 P62877 CUL1 Homo sapiens Q13616
Neddylase Assay
24949976
种属内
RBX1 P62877 CUL1 Homo sapiens Q13616
Anti Tag CoIP
33692209
种属内
RBX1 P62877 CUL1 Homo sapiens Q13616
Anti Bait CoIP
12504026
种属内
RBX1 P62877 CUL1 Homo sapiens Q13616
Anti Tag CoIP
33961781
种属内
RBX1 P62877 CUL4B Homo sapiens Q13620
Anti Tag CoIP
23238014
种属内
RBX1 P62877 CUL4B Homo sapiens Q13620
Anti Tag CoIP
33961781
种属内
RBX1 P62877 CUL2 Homo sapiens Q13617
Anti Tag CoIP
33961781
种属内
RBX1 P62877 CUL2 Homo sapiens Q13617
Validated Y2H
32296183
种属内
RBX1 P62877 CUL2 Homo sapiens Q13617
Y2H Array
32296183
种属内
RBX1 P62877 CUL2 Homo sapiens Q13617
Y2H Prey Pooling
32296183
种属内
RBX1 P62877 CUL2 Homo sapiens Q13617
Pull Down
17183367
种属内
RBX1 P62877 SKP2 Homo sapiens Q13309
Anti Tag CoIP
33961781
种属内
RBX1 P62877 SKP2 Homo sapiens Q13309
Anti Tag CoIP
18239684
种属内
RBX1 P62877 GLMN Homo sapiens Q92990
Anti Tag CoIP
33961781
种属内
RBX1 P62877 GLMN Homo sapiens Q92990
Validated Y2H
32296183
种属内
RBX1 P62877 GLMN Homo sapiens Q92990
Y2H Array
32296183
种属内
RBX1 P62877 GLMN Homo sapiens Q92990
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

RBX1 抗体

目录号 产品名 应用 反应物种
HY-P81379 RBX1 Antibody (YA1124) IHC-P Human

关联疾病

疾病名称 别名
Invasive Bladder Transitional Cell Carcinoma

Invasive Bladder Urothelial Carcinoma

Infiltrating Bladder Urothelial Carcinoma

Mulibrey Nanism

MUL

Muscle-Liver-Brain-Eye Nanism

Pericardial Constriction And Growth Failure

Perheentupa Syndrome

Mulibrey Growth Disorder

Mulibrey Nanism Syndrome

Pericardial Constriction With Growth Failure

Nanism Mulibrey

Smith-Magenis Syndrome

SMS

Chromosome 17p11.2 Deletion Syndrome

17p11.2 Microdeletion Syndrome

17p11.2 Monosomy

Chromosome 17p Deletion Syndrome

Del(17)

P11.2

17p- Syndrome

Deletion 17p Syndrome

Partial Monosomy 17p

Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs

Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V

Xp5

Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype

Xpe

Xp, Group E

Xeroderma Pigmentosum, Type 5

Xeroderma Pigmentosum Complementation Group E

XP-E

Xp Group E

Three M Syndrome 1

3-M Syndrome

Yakut Short Stature Syndrome

3m Syndrome

Le Merrer Syndrome

Dolichospondylic Dysplasia

Gloomy Face Syndrome

Three M Syndrome

3M1

3m Syndrome 1

Miller-Mckusick-Malvaux Syndrome

3-Msbn

Three-M Slender-Boned Nanism

Miller-Mckusick-Malvaux-Syndrome

3-M Syndrome 1

3m Syndrome-1

3m Syndrome, Type 1

Dwarfism

Dwarfism Tall Vertebrae

Retinal Hemangioblastoma

Capillary Hemangioma Of Retina

Kidney Cancer

Renal Cancer

Renal Carcinoma

Kidney Neoplasm

Malignant Neoplasm Of Kidney Except Pelvis

Malignant Tumour Of Kidney

Kidney Neoplasms

Cancer, Kidney

Cancer, Renal

Malignant Neoplasm Of Kidney

Renal Cell Carcinoma

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Uv-Sensitive Syndrome

Uvss

Uv Sensitive Syndrome

Ultraviolet Sensitive Syndrome

Erythrocytosis, Familial, 2

Chuvash Polycythemia

ECYT2

Familial Erythrocytosis 2

Autosomal Recessive Benign Erythrocytosis

Polycythemia, Vhl-Dependent

Chuvash Erythromatosis

Chuvash Type Polycythemia

Chuvash Erythrocytosis

Von Hippel-Lindau-Dependent Polycythemia

Polycythemia Chuvash Type

Vhl-Dependent Polycythemia

Erythrocytosis, Familial, Type 2

Cockayne Syndrome A

Cockayne Syndrome Type 1

Cockayne Syndrome, Type A

Cockayne Syndrome Type I

CSA

Cockayne Syndrome Classic Form

Cockayne Syndrome Classical

Cockayne Syndrome Type A

Ckn1

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability

Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease

Vhl

Vhl Syndrome

VHLS

Von Hippel-Lindau Syndrome, Modifier Of

Hippel Lindau Syndrome

Angiomatosis Retinae

Cerebelloretinal Angiomatosis, Familial

Hippel-Lindau Disease

Familial Cerebelloretinal Angiomatosis

Lindau Disease

VHLD

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RBX1 RGD RGD:1308453
Canis familiaris RBX1 VGNC VGNC:108215
Felis catus RBX1 VGNC VGNC:69274
Mus musculus RBX1 MGD MGI:1891829
Macaca mulatta RBX1 VGNC VGNC:98435
Others RBX1 NCBI